Gene: CCDC77

84318
-
coiled-coil domain containing 77
protein-coding
12p13.33
Ensembl:ENSG00000120647 Vega:OTTHUMG00000129214 UniprotKB:Q9BR77
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
3.000e-1 (AD)  5.067e-1 (ND)   (Frontal_Cortex)
6.853e-1 (AD)  3.001e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs61908460chr12:414895 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD13A0.796
ZNF4510.76
MAP4K50.742
ZNF30.739
SLC35B30.724
MBTD10.724
ZNF5060.723
PTPDC10.721
SRRM10.721
TARSL20.718

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.402
OR4F29-0.396
CHRNA2-0.278
OR4F16-0.274
WNT7B-0.261
SHISA8-0.259
NDNF-0.256
SP8-0.256
DIO2-0.252
WTIP-0.241

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CCDC77 mRNA"27291303
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CCDC77 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CCDC77 mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC77 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of CCDC77 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC77 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CCDC77 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC77 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CCDC77 mRNA28522335
D001379AzathioprineAzathioprine results in decreased expression of CCDC77 mRNA22623647
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCDC77 mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of CCDC77 mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC77 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CCDC77 mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of CCDC77 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CCDC77 mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of CCDC77 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CCDC77 mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC77 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CCDC77 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of CCDC77 mRNA28302478
D004237DiuronDiuron results in increased expression of CCDC77 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCDC77 mRNA22079256
D005485FlutamideFlutamide results in increased expression of CCDC77 mRNA24793618
C069837fullerene C60fullerene C60 results in increased expression of CCDC77 mRNA19167457
C492448ICG 001ICG 001 results in increased expression of CCDC77 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC77 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCDC77 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC77 mRNA28628672
D007854LeadLead affects the expression of CCDC77 mRNA28903495
C045463leflunomideleflunomide results in decreased expression of CCDC77 mRNA28988120
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CCDC77 mRNA"29244179
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CCDC77 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC77 mRNA25729387
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CCDC77 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of CCDC77 mRNA28655636
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC77 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CCDC77 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CCDC77 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of CCDC77 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCDC77 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CCDC77 mRNA22079256
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CCDC77 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCDC77 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCDC77 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CCDC77 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC77 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of CCDC77 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CCDC77 mRNA"26179874
D014520UrethaneUrethane results in increased expression of CCDC77 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CCDC77 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of CCDC77 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CCDC77 mRNA15901671
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CCDC77 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of CCDC77 mRNA28655636

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA21399614  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal