Gene: UTF1

8433
-
undifferentiated embryonic cell transcription factor 1
protein-coding
10q26.3
Ensembl:ENSG00000171794 MIM:604130 Vega:OTTHUMG00000019302 UniprotKB:Q5T230
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.073e-1 (AD)  3.709e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPW0.561
PTH20.496
CRYBB20.494
RRAD0.476
DEFB1150.473
GCM10.463
PLA2G2E0.462
IFNA50.459
GJA80.452
OPN1MW20.45

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IPP-0.308
MATN3-0.304
OMD-0.301
ANXA3-0.301
RBMS3-0.3
IMPACT-0.297
RPS6KA5-0.294
ZNF665-0.287
ST6GALNAC1-0.286
RBM43-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
D019342Acetic AcidAcetic Acid affects the expression of UTF1 protein21296659
D001151ArsenicArsenic results in increased methylation of UTF1 promoter21291286
C487081belinostatbelinostat results in increased expression of UTF1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C006780bisphenol Abisphenol A affects the expression of UTF1 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid affects the expression of UTF1 protein21296659
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UTF1 gene20938992
D002945CisplatinCisplatin results in decreased phosphorylation of UTF1 protein22006019
D004041Dietary FatsDietary Fats results in increased expression of UTF1 mRNA25016146
C118739entinostatentinostat results in increased expression of UTF1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UTF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTF1 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UTF1 gene20938992
D004397FonofosFonofos results in increased methylation of UTF1 promoter22847954
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UTF1 gene20938992
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UTF1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of UTF1 mRNA26272509
D010278ParathionParathion results in increased methylation of UTF1 promoter22847954
D010936Plant ExtractsPlant Extracts results in decreased expression of UTF1 mRNA23557933
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of UTF1 mRNA21427059
D016559TacrolimusTacrolimus results in decreased expression of UTF1 mRNA25270620
C012568terbufosterbufos results in increased methylation of UTF1 promoter22847954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTF1 mRNA17942748
D014212TretinoinTretinoin results in decreased expression of UTF1 mRNA17138961
D014212TretinoinTretinoin results in decreased expression of UTF1 mRNA16604517
D014635Valproic AcidValproic Acid affects the expression of UTF1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UTF1 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in increased methylation of UTF1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of UTF1 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IDA9748258  
GO:0005515protein binding-IPI9748258  
GO:0071837HMG box domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS9748258  
GO:0008584male gonad development-IEP18281244  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9748258  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IC9748258  
GO:0005634nucleus-IDA18281244  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett