Gene: AKT1S1

84335
Lobe|PRAS40
AKT1 substrate 1
protein-coding
19q13.33
Ensembl:ENSG00000204673 MIM:610221 Vega:OTTHUMG00000150246 UniprotKB:Q96B36
NC_000019.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.929e-1 (AD)  7.474e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2290775chr19:49871985 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAF10.921
UBE2J20.918
FAM3A0.905
SGTA0.905
TMEM1470.892
NUDT16L10.892
THAP40.891
RBM420.891
RAB11B0.89
ELOF10.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.774
OR4F29-0.727
PZP-0.258
COL14A1-0.257
HMCN1-0.256
DNASE1L3-0.251
CASQ2-0.251
IFNG-0.246
PLN-0.243
GSDMA-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of AKT1S1 protein"20103642|2053872
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]"20880397
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in decreased phosphorylation of AKT1S1 protein"20880397
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AKT1S1 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1S1 protein17457363
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of AKT1S1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of AKT1S1 mRNA17562736
C501521Akt-I-1,2 compound"Akt-I-1,2 compound results in decreased phosphorylation of AKT1S1 protein"20880397
C071942arctigeninarctigenin results in decreased phosphorylation of AKT1S1 protein25380086
C071942arctigeninQuercetin promotes the reaction [arctigenin results in decreased phosphorylation of AKT1S1 protein]25380086
D001280AtrazineAtrazine results in decreased expression of AKT1S1 mRNA22378314
C060988baohuoside Ibaohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]25119583
C060988baohuoside Ibaohuoside I results in decreased phosphorylation of AKT1S1 protein25119583
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AKT1S1 mRNA27195522
D004958EstradiolEstradiol results in increased phosphorylation of AKT1S1 protein27026707
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of AKT1S1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of AKT1S1 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of AKT1S1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of AKT1S1 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of AKT1S1 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of AKT1S1 mRNA19549813
C030973cupric oxidecupric oxide results in increased phosphorylation of AKT1S1 protein25470785
D016572CyclosporineCyclosporine results in decreased expression of AKT1S1 mRNA25562108
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKT1S1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AKT1S1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKT1S1 mRNA17942748
D018120FinasterideFinasteride results in increased expression of AKT1S1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of AKT1S1 mRNA24136188
C069837fullerene C60fullerene C60 results in increased expression of AKT1S1 mRNA19167457
D017313FenretinideFenretinide results in decreased expression of AKT1S1 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of AKT1S1 mRNA26191083
C029310lardlard results in decreased expression of AKT1S1 mRNA26115784
C045463leflunomideleflunomide results in decreased expression of AKT1S1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of AKT1S1 mRNA24136188
D008628MercuryMercury results in decreased expression of AKT1S1 mRNA22008530
C548887MK 2206MK 2206 results in decreased phosphorylation of AKT1S1 protein28634229
C548887MK 2206[STO 609 co-treated with MK 2206] results in decreased phosphorylation of AKT1S1 protein28634229
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of AKT1S1 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AKT1S1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AKT1S1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of AKT1S1 mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of AKT1S1 mRNA19167457
C012655nimesulidenimesulide results in increased expression of AKT1S1 mRNA24136188
C507134ON 01910ON 01910 results in decreased phosphorylation of AKT1S1 protein25316768
C062258Pasteurella multocida toxinPasteurella multocida toxin results in increased phosphorylation of AKT1S1 protein26369790
D010416PentachlorophenolPentachlorophenol results in increased expression of AKT1S1 mRNA24642059
D010634PhenobarbitalPhenobarbital results in increased expression of AKT1S1 mRNA19270015
C522973PI103PI103 inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]20880397
C522973PI103PI103 results in decreased phosphorylation of AKT1S1 protein20880397
C006253pirinixic acidpirinixic acid results in decreased expression of AKT1S1 mRNA25270620
D010936Plant ExtractsPlant Extracts results in decreased expression of AKT1S1 mRNA23557933
D011794QuercetinQuercetin promotes the reaction [arctigenin results in decreased phosphorylation of AKT1S1 protein]25380086
C059514resveratrolresveratrol results in decreased phosphorylation of AKT1S1 protein25311616
C059514resveratrolresveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]24304514
C059514resveratrolresveratrol promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]24304514
C059514resveratrolresveratrol results in decreased phosphorylation of AKT1S1 protein24304514
C059514resveratrol[Sirolimus co-treated with resveratrol] results in decreased phosphorylation of AKT1S1 protein24304514
C059514resveratrol[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of AKT1S1 protein24304514
C059514resveratrolresveratrol results in decreased phosphorylation of AKT1S1 protein24304514
D020123Sirolimusresveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]24304514
D020123Sirolimus[Sirolimus co-treated with resveratrol] results in decreased phosphorylation of AKT1S1 protein24304514
D020123SirolimusSirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]24304514
D020123Sirolimus[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of AKT1S1 protein24304514
C017947sodium arsenitesodium arsenite results in increased expression of AKT1S1 mRNA21297353
D012969Sodium FluorideSodium Fluoride results in decreased expression of AKT1S1 protein28918527
C458525STO 609[STO 609 co-treated with MK 2206] results in decreased phosphorylation of AKT1S1 protein28634229
C458525STO 609STO 609 results in decreased phosphorylation of AKT1S1 protein28634229
D013467SulindacSulindac results in decreased expression of AKT1S1 mRNA24136188
D013605T-2 ToxinT-2 Toxin results in increased expression of AKT1S1 mRNA26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AKT1S1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AKT1S1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased phosphorylation of AKT1S1 protein23639626
D013806TheophyllineTheophylline results in increased expression of AKT1S1 mRNA18951874
C009495titanium dioxidetitanium dioxide results in increased expression of AKT1S1 mRNA29128614
C012589trichostatin Atrichostatin A results in increased expression of AKT1S1 mRNA15901671
D014520UrethaneUrethane results in increased expression of AKT1S1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of AKT1S1 mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of AKT1S1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of AKT1S1 gene29154799
C009687wortmanninwortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]20880397
C009687wortmanninwortmannin results in decreased phosphorylation of AKT1S1 protein20880397
C088658zoledronic acidzoledronic acid results in increased expression of AKT1S1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12524439  17386266  17604271  17979178  19648646  
GO ID GO Term Qualifier Evidence PubMed
GO:0006469negative regulation of protein kinase activity-IBA21873635  
GO:0006469negative regulation of protein kinase activity-IDA17386266  
GO:0032007negative regulation of TOR signaling-IBA21873635  
GO:0032007negative regulation of TOR signaling-IDA17386266  
GO:0038202TORC1 signaling-IBA21873635  
GO:0042981regulation of apoptotic process-ISS-  
GO:0043523regulation of neuron apoptotic process-ISS-  
GO:0045792negative regulation of cell size-IDA17386266  
GO:0048011neurotrophin TRK receptor signaling pathway-IEA-  
GO:1900034regulation of cellular response to heat-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0031931TORC1 complex-IBA21873635  
GO:0031931TORC1 complexcolocalizes_withIDA17386266  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-165159mTOR signallingTAS
R-HSA-166208mTORC1-mediated signallingTAS
R-HSA-198323AKT phosphorylates targets in the cytosolTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-3371571HSF1-dependent transactivationTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal