Gene: RECK

8434
ST15
reversion inducing cysteine rich protein with kazal motifs
protein-coding
9p13.3
Ensembl:ENSG00000122707 MIM:605227 Vega:OTTHUMG00000019898 UniprotKB:O95980
NC_000009.12
PubMed
0   ANCO-SNPs
CD|ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.106e-1 (AD)  9.486e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WDR110.882
CREBZF0.877
NKTR0.875
AGO40.874
RBM250.868
MTF20.858
PEX10.858
TAF10.855
TTC170.849
NFATC2IP0.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.465
OR4F29-0.437
S100A1-0.262
KLRC2-0.252
MTRNR2L6-0.251
MTRNR2L9-0.245
MTRNR2L10-0.243
NR0B1-0.241
C7orf61-0.238
FOXJ1-0.237

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of RECK mRNA28329830
C5740372-(1-hydroxy-4-oxocyclohexa-2,5-dienyl)pyran-4-one"2-(1-hydroxy-4-oxocyclohexa-2,5-dienyl)pyran-4-one results in increased expression of RECK"24300195
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in decreased expression of RECK protein]26026961
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in decreased expression of RECK protein]"26026961
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RECK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RECK mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of RECK mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RECK protein20106945
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RECK mRNA24449571
D001280AtrazineAtrazine results in decreased expression of RECK mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of RECK mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RECK mRNA21632981
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of RECK mRNA20660070
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RECK mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of RECK mRNA21932408
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RECK mRNA28628672
D002122Calcium ChlorideCalcium Chloride results in increased expression of RECK protein25824407
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RECK mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in increased expression of RECK mRNA20350560
D003042CocaineCocaine results in increased expression of RECK protein18000554
D019327Copper SulfateCopper Sulfate results in decreased expression of RECK mRNA19549813
C015763cumenecumene results in decreased expression of RECK mRNA18648096
D003471CuprizoneCuprizone results in increased expression of RECK mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of RECK mRNA25562108|2798913
D000069439DasatinibDasatinib results in increased expression of RECK mRNA20579391
C014347decitabinedecitabine affects the expression of RECK mRNA17233834
C014347decitabinedecitabine affects the methylation of RECK promoter17443689
C014347decitabine[decitabine affects the methylation of RECK promoter] which affects the expression of RECK mRNA17443689|1744368
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in decreased expression of RECK mRNA]21167264
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in decreased expression of RECK protein]21167264
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RECK mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RECK mRNA28628672
D002945CisplatinCisplatin results in increased expression of RECK mRNA21151649
D004041Dietary FatsDietary Fats results in decreased expression of RECK mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of RECK mRNA24535843
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RECK protein"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RECK protein]"21294050
D004237DiuronDiuron results in decreased expression of RECK mRNA25152437
D004610Ellagic AcidEllagic Acid results in increased expression of RECK mRNA21573219
D004610Ellagic AcidEllagic Acid results in increased expression of RECK protein21573219
D004610Ellagic Acidzinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]21573219
D004610Ellagic Acidzinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein]21573219
D004640EmetineEmetine results in decreased expression of RECK mRNA26332055
C118739entinostatentinostat results in increased expression of RECK mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RECK mRNA22079256
D005054EugenolEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]20434464
D005054EugenolEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein]20434464
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of RECK mRNA28329830
D005492Folic AcidFolic Acid affects the expression of RECK mRNA17320366
D017313FenretinideFenretinide results in decreased expression of RECK mRNA28973697
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RECK protein18951874
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RECK mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RECK mRNA28628672
C051890irinotecanirinotecan analog results in increased expression of RECK mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of RECK mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RECK mRNA28628672
C005219methyl cellosolvemethyl cellosolve results in increased expression of RECK mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RECK mRNA23103053
D008769MethylnitronitrosoguanidineEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK mRNA]20434464
D008769MethylnitronitrosoguanidineEugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of RECK protein]20434464
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of RECK mRNA20434464
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of RECK protein20434464
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RECK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RECK mRNA"25554681
D009532NickelNickel results in decreased expression of RECK mRNA25583101
C022838nickel chloride3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in decreased expression of RECK protein]26026961
C022838nickel chloride"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in decreased expression of RECK protein]"26026961
C022838nickel chloridenickel chloride results in decreased expression of RECK protein26026961
C022838nickel chloride[nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of RECK protein26026961
C022838nickel chlorideRECK protein inhibits the reaction [nickel chloride results in increased expression of EGFR protein]26026961
C029938nickel sulfatenickel sulfate results in decreased expression of RECK mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RECK mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of RECK mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of RECK mRNA18042831
C016030pantogabpantogab results in decreased expression of RECK mRNA17379144
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of RECK mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of RECK mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RECK mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of RECK mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of RECK mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RECK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of RECK mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of RECK mRNA20660070
D011794QuercetinQuercetin results in increased expression of RECK mRNA21632981
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of RECK protein]"21294050
C059514resveratrolresveratrol results in decreased expression of RECK protein18089832
D012643SeleniumSelenium results in decreased expression of RECK mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RECK mRNA25895662
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in decreased expression of RECK mRNA]21167264
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in decreased expression of RECK protein]21167264
C017947sodium arsenitesodium arsenite results in decreased expression of RECK mRNA21167264
C017947sodium arsenitesodium arsenite results in decreased expression of RECK protein21167264
C017947sodium arsenitesodium arsenite results in increased methylation of RECK promoter21167264
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in decreased expression of RECK mRNA]21167264
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in decreased expression of RECK protein]21167264
C017947sodium arsenitesodium arsenite results in decreased expression of RECK protein21167264
C012037solasodinesolasodine results in increased expression of RECK mRNA28283413
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RECK mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RECK gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RECK mRNA20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RECK mRNA22298810
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RECK protein18951874
C009495titanium dioxidetitanium dioxide affects the expression of RECK mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RECK mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of RECK mRNA28111298
C003677tomatidinetomatidine results in increased expression of RECK mRNA23566884
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RECK mRNA25729387
D019772TopotecanTopotecan results in increased expression of RECK mRNA25729387
D014212TretinoinTretinoin results in increased expression of RECK mRNA23724009
D014212TretinoinTretinoin results in increased expression of RECK mRNA16604517
C012589trichostatin Atrichostatin A affects the expression of RECK mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of RECK mRNA24935251
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in decreased expression of RECK mRNA]21167264
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in decreased expression of RECK protein]21167264
D014520UrethaneUrethane results in decreased expression of RECK mRNA16289808
D014635Valproic AcidValproic Acid results in decreased expression of RECK mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of RECK mRNA19101580|2493525
C029297vinylidene chloridevinylidene chloride results in decreased expression of RECK mRNA26682919
C016837zinc chloridezinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK mRNA]21573219
C016837zinc chloridezinc chloride inhibits the reaction [Ellagic Acid results in increased expression of RECK protein]21573219

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-IDA9789069  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0005515protein binding-IPI21255571  
GO:0008191metalloendopeptidase inhibitor activity-TAS9789069  
GO ID GO Term Qualifier Evidence PubMed
GO:0001955blood vessel maturation-IEA-  
GO:0007566embryo implantation-IEA-  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030198extracellular matrix organization-IEA-  
GO:0030336negative regulation of cell migration-IMP18591254  
GO:0035115embryonic forelimb morphogenesis-IEA-  
GO:1904684negative regulation of metalloendopeptidase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-IBA21873635  
GO:0016020membrane-TAS9789069  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18000554Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. (2007 Nov 14)Mash DCPLoS One
24510537RECK gene polymorphisms influence NSCLC susceptibility, but not the chemotherapy response status in Chinese cohort. (2014 Jul)Chen XCell Biochem Biophys
26026961Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. (2015 Aug 19)Chiou YHToxicol Lett
27575817Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis. (2016)Navratilova ZPLoS One
21565829Impact of RECK gene polymorphisms and environmental factors on oral cancer susceptibility and clinicopathologic characteristics in Taiwan. (2011 Jul)Chung TTCarcinogenesis