Gene: SOAT2

8435
ACACT2|ACAT2|ARGP2
sterol O-acyltransferase 2
protein-coding
12q13.13
Ensembl:ENSG00000167780 MIM:601311 Vega:OTTHUMG00000169774 UniprotKB:O75908
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.910e-2 (AD)  3.100e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C11orf160.443
KCNA70.437
HMCN10.422
LEUTX0.41
OR9K20.403
NR2F2-AS10.402
LIN28A0.4
DCAF8L20.392
ZSCAN5C0.384
DSG20.382

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHADL-0.285
KIAA1755-0.28
MAL-0.279
PHGDH-0.271
FAM69C-0.27
CMTM5-0.265
IZUMO4-0.262
GABRG1-0.262
MEGF10-0.26
SORCS2-0.258

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01094HesperetinSmall Molecule520-33-2ApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of SOAT2 mRNA"28903501
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SOAT2 mRNA"28433925
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of SOAT2 mRNA"21218783
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SOAT2 mRNA19038236
D000082AcetaminophenAcetaminophen affects the expression of SOAT2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SOAT2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SOAT2 mRNA16483693
D001507BeclomethasoneBeclomethasone results in increased expression of SOAT2 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOAT2 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SOAT2 mRNA21715664
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SOAT2 mRNA25566086
C006780bisphenol Abisphenol A results in decreased methylation of SOAT2 promoter27312807
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SOAT2 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of SOAT2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SOAT2 mRNA26079696
D002185CannabidiolCannabidiol results in increased expression of SOAT2 mRNA21542829
D002586CesiumCesium results in decreased expression of SOAT2 mRNA20173315
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SOAT2 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of SOAT2 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of SOAT2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SOAT2 mRNA25562108
D013759DronabinolDronabinol results in increased expression of SOAT2 mRNA21542829
C016366dibenzothiophenedibenzothiophene results in decreased expression of SOAT2 mRNA23656968
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SOAT2 mRNA28433925
D004041Dietary Fatseicosapentaenoic acid ethyl ester inhibits the reaction [[Sodium Cholate co-treated with Dietary Fats] results in increased expression of SOAT2 mRNA]23665937
D004041Dietary Fats[Sodium Cholate co-treated with Dietary Fats] results in increased expression of SOAT2 mRNA23665937
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of SOAT2 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SOAT2 mRNA"28433925
D004391DustDust results in decreased expression of SOAT2 mRNA17805423
C035276eicosapentaenoic acid ethyl estereicosapentaenoic acid ethyl ester inhibits the reaction [[Sodium Cholate co-treated with Dietary Fats] results in increased expression of SOAT2 mRNA]23665937
D004603Elements, Radioactive"Elements, Radioactive results in decreased expression of SOAT2 mRNA"20173315
C082360fipronilfipronil results in decreased expression of SOAT2 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of SOAT2 mRNA24793618
D005632FructoseFructose results in decreased expression of SOAT2 mRNA19193814
C412815GW 4064GW 4064 results in increased expression of SOAT2 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of SOAT2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SOAT2 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SOAT2 mRNA25613284
C011890kojic acidkojic acid results in increased expression of SOAT2 mRNA16595896
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of SOAT2 mRNA22401849
C500085muraglitazarmuraglitazar results in increased expression of SOAT2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SOAT2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SOAT2 mRNA"25554681
C458513pafuramidineSOAT2 affects the reaction [pafuramidine results in increased expression of HAVCR1 protein]22940726
D010416PentachlorophenolPentachlorophenol results in decreased expression of SOAT2 mRNA23892564
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SOAT2 mRNA17097637
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of SOAT2 mRNA28903501
D011794QuercetinQuercetin results in decreased expression of SOAT2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SOAT2 mRNA25895662
D012834SilverSilver results in increased expression of SOAT2 mRNA27131904
D020358Sodium Cholateeicosapentaenoic acid ethyl ester inhibits the reaction [[Sodium Cholate co-treated with Dietary Fats] results in increased expression of SOAT2 mRNA]23665937
D020358Sodium Cholate[Sodium Cholate co-treated with Dietary Fats] results in increased expression of SOAT2 mRNA23665937
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SOAT2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOAT2 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of SOAT2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SOAT2 mRNA28238261
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SOAT2 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SOAT2 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SOAT2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SOAT2 mRNA21515302
D014520UrethaneUrethane results in decreased expression of SOAT2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SOAT2 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of SOAT2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SOAT2 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of SOAT2 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000062fatty-acyl-CoA binding-IDA16647063  
GO:0008374O-acyltransferase activity-IBA21873635  
GO:0015485cholesterol binding-IDA16647063  
GO:0016746transferase activity, transferring acyl groups-TAS9756920  
GO:0034736cholesterol O-acyltransferase activity-IBA21873635  
GO:0034736cholesterol O-acyltransferase activity-IDA16647063  
GO:0034736cholesterol O-acyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008203cholesterol metabolic process-IBA21873635  
GO:0008203cholesterol metabolic process-IDA16647063  
GO:0010742macrophage derived foam cell differentiation-TAS14615411  
GO:0030299intestinal cholesterol absorption-IC14615411  
GO:0033344cholesterol efflux-IMP15308631  
GO:0034379very-low-density lipoprotein particle assembly-IMP15308631  
GO:0034383low-density lipoprotein particle clearance-TAS-  
GO:0034435cholesterol esterification-IDA16647063  
GO:0042632cholesterol homeostasis-TAS11401500  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA15451793  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IDA12808042  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005903brush border-IDA14615411  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00100Steroid biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8964038LDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19878569Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (2009 Oct 30)Chen SNBMC Med Genet