Gene: RAD54L

8438
HR54|RAD54A|hHR54|hRAD54
RAD54 like
protein-coding
1p34.1
Ensembl:ENSG00000085999 MIM:603615 Vega:OTTHUMG00000007772 UniprotKB:Q92698
NG_012144.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.033e-1 (AD)  8.874e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH20.828
PASK0.815
ZGLP10.801
TMEM810.795
SPAG50.78
HIC20.768
TRIM110.764
CPO0.763
GSDMB0.761
GNB30.757

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBNL3-0.399
KLRB1-0.393
RGS22-0.384
NXT2-0.377
LRRCC1-0.369
ASB4-0.369
TSPAN12-0.363
HSD17B8-0.357
MAPKAPK3-0.355
DPH6-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of RAD54L mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RAD54L mRNA"27291303
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RAD54L mRNA"19167446
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of RAD54L mRNA"20713471
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of RAD54L mRNA"20816883
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of RAD54L mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of RAD54L mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of RAD54L protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RAD54L mRNA22100608
C103505AM 251AM 251 results in decreased expression of RAD54L mRNA16500647
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RAD54L mRNA"22863853
D001151ArsenicArsenic affects the methylation of RAD54L gene25304211
C015001arsenitearsenite results in decreased expression of RAD54L mRNA18929588
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RAD54L mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RAD54L mRNA20713471
C522781biflorinbiflorin affects the expression of RAD54L mRNA27079618
C006780bisphenol Abisphenol A affects the expression of RAD54L mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RAD54L mRNA29275510
C006780bisphenol Abisphenol A affects the expression of RAD54L mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of RAD54L mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RAD54L mRNA17484886
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of RAD54L mRNA28472532
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RAD54L mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of RAD54L mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RAD54L mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of RAD54L mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of RAD54L mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of RAD54L mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of RAD54L mRNA21878529
D003520CyclophosphamideCyclophosphamide results in decreased expression of RAD54L mRNA11056294
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RAD54L mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of RAD54L mRNA21151649
D004041Dietary FatsDietary Fats results in increased expression of RAD54L mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of RAD54L mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RAD54L mRNA21592394
D005047EtoposideBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]16417649
D005047EtoposideEtoposide results in increased expression of RAD54L protein16417649
C492448ICG 001ICG 001 results in increased expression of RAD54L mRNA26191083
C056493imiquimodimiquimod results in decreased expression of RAD54L mRNA21878529
D007213IndomethacinIndomethacin results in increased expression of RAD54L mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RAD54L mRNA24796395|2596192
D007854LeadLead affects the expression of RAD54L mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RAD54L mRNA21641980
D008694MethamphetamineMethamphetamine results in increased methylation of RAD54L promoter26307267
D008748MethylcholanthreneMethylcholanthrene results in increased expression of RAD54L mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RAD54L mRNA26011545
D009151Mustard GasMustard Gas results in decreased expression of RAD54L mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RAD54L mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RAD54L mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RAD54L mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD54L mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RAD54L mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of RAD54L mRNA26516004
D010126OzoneOzone results in decreased expression of RAD54L mRNA24336422
D010416PentachlorophenolPentachlorophenol results in increased expression of RAD54L mRNA24642059
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of RAD54L mRNA21334430
C005556propionaldehydepropionaldehyde results in decreased expression of RAD54L mRNA26079696
D011794QuercetinQuercetin results in increased expression of RAD54L mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of RAD54L mRNA19167446
C547185riccardin Driccardin D results in decreased expression of RAD54L mRNA24069304
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of RAD54L mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RAD54L mRNA19073995
C017947sodium arsenitesodium arsenite affects the methylation of RAD54L gene28589171
D053260SootSoot results in increased expression of RAD54L mRNA26551751
C075117squalestatin 1squalestatin 1 results in decreased expression of RAD54L mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of RAD54L mRNA27225895
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RAD54L mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RAD54L mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RAD54L mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAD54L mRNA16714409
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD54L mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RAD54L mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RAD54L mRNA21570461
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RAD54L mRNA16979875
D019284ThapsigarginThapsigargin results in decreased expression of RAD54L mRNA22378314
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RAD54L mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RAD54L mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RAD54L mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of RAD54L mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of RAD54L mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of RAD54L mRNA22378314
C025643vinclozolinvinclozolin results in decreased expression of RAD54L mRNA23555832
D014750VincristineVincristine results in decreased expression of RAD54L mRNA23649840
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of RAD54L mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0004386helicase activity-IEA-  
GO:0005515protein binding-IPI16990250  22153077  25416956  
GO:0005524ATP binding-IEA-  
GO:0036310annealing helicase activity-IDA22705370  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IEA-  
GO:0000733DNA strand renaturation-IEA-  
GO:0006281DNA repair-TAS8805304  
GO:0006310DNA recombination-TAS8805304  
GO:0008340determination of adult lifespan-IEA-  
GO:0010212response to ionizing radiation-IEA-  
GO:0042493response to drug-IEA-  
GO:0051321meiotic cell cycle-TAS8805304  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-TAS8805304  
GO:0005654nucleoplasm-IDA-  
GO:0032991protein-containing complex-IMP16990250  
KEGG ID KEGG Term
hsa03440Homologous recombination
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147782DNA repair gene polymorphisms and risk of pancreatic cancer. (2009 Jan 15)Li DClin Cancer Res