Gene: GNPAT

8443
DAP-AT|DAPAT|DHAPAT|RCDP2
glyceronephosphate O-acyltransferase
protein-coding
1q42.2
Ensembl:ENSG00000116906 MIM:602744 Vega:OTTHUMG00000038024 UniprotKB:O15228
NG_008240.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.107e-1 (AD)  9.437e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBA30.936
GDI20.934
FEZ20.932
ESD0.931
TMEM590.925
MFF0.923
LMBRD10.92
BUB30.918
VAPA0.916
PAIP10.915

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.779
OR4F29-0.752
KLRB1-0.221
C8orf74-0.212
MROH9-0.196
TAS2R13-0.191
MTRNR2L6-0.191
OR52H1-0.189
NEUROG1-0.188
PRDM14-0.187

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0380902,2-dithiobis(4,6-dichlorophenol)"GNPAT gene SNP affects the susceptibility to 2,2-dithiobis(4,6-dichlorophenol)"25622337
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GNPAT mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GNPAT mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of GNPAT mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of GNPAT mRNA17585979
D020106AcrylamideAcrylamide affects the expression of GNPAT mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GNPAT gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GNPAT mRNA16483693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of GNPAT mRNA26377693
C006780bisphenol Abisphenol A affects the expression of GNPAT mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GNPAT gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GNPAT mRNA23741332
D019327Copper SulfateCopper Sulfate results in decreased expression of GNPAT mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of GNPAT mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GNPAT mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of GNPAT mRNA28302478
D000431EthanolEthanol results in increased expression of GNPAT mRNA17920746
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GNPAT mRNA17555576
D018120FinasterideFinasteride results in increased expression of GNPAT mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of GNPAT mRNA17183730
D006854HydrocortisoneHydrocortisone results in increased expression of GNPAT mRNA25763180
D006854HydrocortisoneMifepristone inhibits the reaction [Hydrocortisone results in increased expression of GNPAT mRNA]25763180
C492448ICG 001ICG 001 results in decreased expression of GNPAT mRNA26191083
D007854LeadLead affects the expression of GNPAT mRNA28903495
D018021Lithium ChlorideLithium Chloride results in decreased expression of GNPAT mRNA23527032
C005219methyl cellosolvemethyl cellosolve results in increased expression of GNPAT mRNA21061450
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GNPAT mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of GNPAT mRNA29191790
D015735MifepristoneMifepristone inhibits the reaction [Hydrocortisone results in increased expression of GNPAT mRNA]25763180
D010634PhenobarbitalPhenobarbital affects the expression of GNPAT mRNA19136022
D010795Phthalic AcidsPhthalic Acids results in increased expression of GNPAT mRNA21061450
C006253pirinixic acidpirinixic acid affects the expression of GNPAT mRNA19136022
C006253pirinixic acidpirinixic acid results in increased expression of GNPAT mRNA17950772|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of GNPAT mRNA]17950772
C006253pirinixic acidpirinixic acid results in increased expression of GNPAT mRNA19162173
D015474IsotretinoinIsotretinoin results in decreased expression of GNPAT mRNA20436886
D012999SomanSoman results in decreased expression of GNPAT mRNA19281266
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of GNPAT mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GNPAT mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GNPAT mRNA16054898
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of GNPAT mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GNPAT gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of GNPAT mRNA20044591
D015032ZincZinc deficiency results in increased expression of GNPAT mRNA15671213

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004366glycerol-3-phosphate O-acyltransferase activity-IBA21873635  
GO:0005102signaling receptor binding-IPI20178365  
GO:0016287glycerone-phosphate O-acyltransferase activity-IBA21873635  
GO:0016287glycerone-phosphate O-acyltransferase activity-IDA8186247  9536089  15687349  
GO:0016287glycerone-phosphate O-acyltransferase activity-TAS-  
GO:0016290palmitoyl-CoA hydrolase activity-IDA8186247  
GO ID GO Term Qualifier Evidence PubMed
GO:0006072glycerol-3-phosphate metabolic process-IBA21873635  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006631fatty acid metabolic process-IBA21873635  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0007416synapse assembly-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0008611ether lipid biosynthetic process-IBA21873635  
GO:0008611ether lipid biosynthetic process-IDA15687349  
GO:0008611ether lipid biosynthetic process-TAS-  
GO:0008654phospholipid biosynthetic process-IBA21873635  
GO:0019432triglyceride biosynthetic process-IBA21873635  
GO:0021587cerebellum morphogenesis-IEA-  
GO:0030913paranodal junction assembly-IEA-  
GO:0042493response to drug-IEA-  
GO:0042594response to starvation-IEA-  
GO:0061024membrane organization-IEA-  
GO:0070542response to fatty acid-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0005777peroxisome-IDA15687349  
GO:0005777peroxisome-NAS9459311  
GO:0005778peroxisomal membrane-HDA21525035  
GO:0005778peroxisomal membrane-IBA21873635  
GO:0005778peroxisomal membrane-TAS-  
GO:0005782peroxisomal matrix-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0016020membrane-HDA19946888  
GO:0031966mitochondrial membrane-IBA21873635  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75896Plasmalogen biosynthesisTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26474245The role of genetic factors in patients with hepatocellular carcinoma and iron overload - a prospective series of 234 patients. (2016 May)Funakoshi NLiver Int