Gene: PROK1

84432
EGVEGF|PK1|PRK1
prokineticin 1
protein-coding
1p13.3
Ensembl:ENSG00000143125 MIM:606233 Vega:OTTHUMG00000011569 UniprotKB:P58294
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.670e-1 (AD)  8.078e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22697365chr1:110993041PROK1Promoter5.593e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPA40.513
PDE6B0.448
CDK180.444
CPA50.444
SHB0.443
MVK0.44
PRR40.439
C19orf570.436
SMPDL3B0.434
PTK70.431

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNJ16-0.301
NDNF-0.293
FOXL1-0.281
CGNL1-0.278
ASB4-0.277
WTIP-0.275
RERGL-0.271
HCAR1-0.27
PON3-0.265
SLC40A1-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PROK1 mRNA"27413110
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PROK1 mRNA"28903501
D000242Cyclic AMPPROK1 protein affects the susceptibility to Cyclic AMP21546446
D000452AldrinAldrin results in increased expression of PROK1 mRNA18579281
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PROK1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PROK1 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of PROK1 mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of PROK1 protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA18160741
C062876cetrorelix[cetrorelix co-treated with testosterone enanthate] results in decreased expression of PROK1 mRNA18160741
D002927CimetidineCimetidine results in decreased expression of PROK1 protein26021711
D019327Copper SulfateCopper Sulfate results in increased expression of PROK1 mRNA18579281
D017135Desogestrel[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA18160741
D003976DiazinonDiazinon affects the expression of PROK1 mRNA22546817
C118739entinostatentinostat results in increased expression of PROK1 mRNA27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PROK1 mRNA"25620056
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
C022838nickel chloridenickel chloride affects the expression of PROK1 mRNA22546817
D009538NicotineNicotine results in decreased expression of PROK1 protein24368670
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of PROK1 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of PROK1 mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in decreased expression of PROK1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PROK1 mRNA27413110
D011374ProgesteroneProgesterone results in increased expression of PROK1 mRNA21540246
D011374ProgesteronePROK1 protein affects the susceptibility to Progesterone21546446
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of PROK1 protein]22150557
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA"18579281
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA18160741
C004648testosterone enanthate[cetrorelix co-treated with testosterone enanthate] results in decreased expression of PROK1 mRNA18160741
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PROK1 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PROK1 mRNA25549359
D014635Valproic AcidValproic Acid affects the expression of PROK1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PROK1 gene25560391
D014752Vinyl ChlorideVinyl Chloride results in increased expression of PROK1 mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-IBA21873635  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IBA21873635  
GO:0001525angiogenesis-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007623circadian rhythm-IBA21873635  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0045765regulation of angiogenesis-IBA21873635  
GO:0051781positive regulation of cell division-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20864676Cotinine exposure increases Fallopian tube PROKR1 expression via nicotinic AChRalpha-7: a potential mechanism explaining the link between smoking and tubal ectopic pregnancy. (2010 Nov)Shaw JLAm J Pathol