Gene: ZNF528

84436
-
zinc finger protein 528
protein-coding
19q13.41
Ensembl:ENSG00000167555 MIM:615580 Vega:OTTHUMG00000156494 UniprotKB:Q3MIS6
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
2.474e-1 (AD)  7.020e-1 (ND)   (Frontal_Cortex)
7.070e-1 (AD)  7.347e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs324119chr19:52396303 (GRCh38.p7)C>A / C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF7930.818
ZNF4930.789
SLC35D10.785
ZNF5510.777
UBN20.774
MPHOSPH90.774
ZNF5490.773
RANBP100.772
OGT0.767
TTC140.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.453
OR4F29-0.414
KLRC2-0.305
KLRC3-0.269
TRDN-0.254
SMIM1-0.251
KRTAP4-3-0.251
MUSK-0.235
C9orf153-0.232
C17orf64-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ZNF528 mRNA27153756
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ZNF528 mRNA22714537
D014638VanadatesVanadates results in decreased expression of ZNF528 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal