Gene: DOT1L

84444
DOT1|KMT4
DOT1 like histone lysine methyltransferase
protein-coding
19p13.3
Ensembl:ENSG00000104885 MIM:607375 Vega:OTTHUMG00000150431 UniprotKB:Q8TEK3
NG_029793.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.092e-1 (AD)  3.819e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYK20.825
TRABD0.813
TSEN540.811
LRCH40.808
FRMD80.807
FAM193B0.801
NOP20.798
NUP1880.795
PCSK70.793
FBRS0.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.426
OR4F29-0.389
DIAPH3-0.263
KLRC2-0.24
GSDMC-0.233
TRDN-0.228
PAGE4-0.201
PTGFR-0.197
MYL1-0.185
MYLPF-0.182

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DOT1L mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DOT1L mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DOT1L mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DOT1L mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOT1L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOT1L mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of DOT1L mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DOT1L mRNA19770486
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DOT1L mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of DOT1L mRNA25181051
D002104CadmiumCadmium results in increased expression of DOT1L mRNA24376830
C026690cerous chloridecerous chloride results in increased expression of DOT1L mRNA23573234
D003300CopperCopper deficiency results in increased expression of DOT1L mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of DOT1L mRNA19549813
D003471CuprizoneCuprizone results in increased expression of DOT1L mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DOT1L mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DOT1L mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DOT1L mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DOT1L mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of DOT1L mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of DOT1L mRNA18042831
C024629dimethyl phthalatedimethyl phthalate affects the expression of DOT1L mRNA26924002
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DOT1L mRNA28329830
D016650Fluorescein-5-isothiocyanateFluorescein-5-isothiocyanate binds to DOT1L protein27129696
C010974glyphosateglyphosate results in increased expression of DOT1L mRNA26302742
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DOT1L mRNA27392435
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DOT1L mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DOT1L mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of DOT1L mRNA26392148
C028007nickel monoxidenickel monoxide results in increased expression of DOT1L mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of DOT1L mRNA18042831
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DOT1L mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of DOT1L mRNA18301758|2381119
D011192Potassium DichromatePotassium Dichromate results in increased expression of DOT1L mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of DOT1L mRNA24780913
D012715Sesame OilSesame Oil results in increased expression of DOT1L mRNA29191790
D012834SilverSilver results in decreased expression of DOT1L mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of DOT1L gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of DOT1L mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DOT1L mRNA21570461
C012589trichostatin Atrichostatin A results in decreased expression of DOT1L mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DOT1L mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DOT1L mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DOT1L mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of DOT1L gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DOT1L gene25560391
C025643vinclozolinvinclozolin results in increased expression of DOT1L mRNA23034163
D019287Zinc SulfateZinc Sulfate results in increased expression of DOT1L mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI20153263  20203130  21103407  23260655  26496610  
GO:0018024histone-lysine N-methyltransferase activity-IDA17707234  
GO:0018024histone-lysine N-methyltransferase activity-TAS-  
GO:0031151histone methyltransferase activity (H3-K79 specific)-IBA21873635  
GO:0042054histone methyltransferase activity-IDA15851025  
GO ID GO Term Qualifier Evidence PubMed
GO:0000077DNA damage checkpoint-IBA21873635  
GO:0006281DNA repair-IBA21873635  
GO:0006348chromatin silencing at telomere-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA15851025  
GO:0032200telomere organization-TAS17675446  
GO:0034729histone H3-K79 methylation-IDA15851025  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA15851025  
GO:0046425regulation of JAK-STAT cascade-IDA22002246  
GO:2000677regulation of transcription regulatory region DNA binding-IBA21873635  
GO:2000677regulation of transcription regulatory region DNA binding-IMP22002246  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15851025  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0032991protein-containing complex-IDA15851025  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00310Lysine degradation
Reactome ID Reactome Term Evidence
R-HSA-3214841PKMTs methylate histone lysinesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
284686312D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls. (2017 May 3)Lakhdar RRespir Res