Gene info: ID 84467

Gene: FBN3

GENE ID: 84467

Synonyms: -

Description: fibrillin 3

Gene type: protein-coding

Location: 19p13.2

dbXrefs: Ensembl:ENSG00000142449 MIM:608529 Vega:OTTHUMG00000182462 UniprotKB:Q75N90

RefSeq: NC_000019.10

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.790e-1 (AD) 9.419e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10411526	chr19:8107797 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GRIK1	0.632
TRIM67	0.618
GRIP2	0.583
ASIC4	0.575
PLCH2	0.571
FREM1	0.57
SEMA5B	0.565
COL9A1	0.564
COL11A1	0.556
KIF26B	0.552

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FKBP5	-0.425
HEBP2	-0.402
CDA	-0.401
SLC16A1	-0.376
STK17B	-0.374
CLEC4E	-0.369
SLC52A3	-0.364
PLIN2	-0.361
PDK4	-0.361
IFITM2	-0.344

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11093	Calcium Citrate	Small Molecule	813-94-5	Approved	Target
DB11348	Calcium Phosphate	Small Molecule	10103-46-5	Approved	Target

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBN3 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBN3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBN3 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBN3 mRNA"	27188386
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of FBN3 mRNA	21298039
C487081	belinostat	belinostat results in decreased expression of FBN3 mRNA	27188386
D003976	Diazinon	Diazinon results in increased methylation of FBN3 gene	22964155
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of FBN3 mRNA	28001369
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBN3 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of FBN3 mRNA	26272509
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBN3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of FBN3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FBN3 mRNA	23179753\|2627250
C111237	vorinostat	vorinostat results in decreased expression of FBN3 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005201	extracellular matrix structural constituent	-	IBA	21873635
GO:0005509	calcium ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0009653	anatomical structure morphogenesis	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0031012	extracellular matrix	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1566948	Elastic fibre formation	TAS
R-HSA-1566948	Elastic fibre formation	IEA
R-HSA-2129379	Molecules associated with elastic fibres	TAS
R-HSA-2129379	Molecules associated with elastic fibres	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal