Gene: CUL4B

8450
CUL-4B|MRXHF2|MRXS15|MRXSC|SFM2
cullin 4B
protein-coding
Xq24
Ensembl:ENSG00000158290 MIM:300304 Vega:OTTHUMG00000022302 UniprotKB:Q13620
NG_009388.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM8A10.954
ZRANB20.944
ZDHHC170.94
KPNA30.939
THUMPD10.939
MARCH60.937
MAP4K30.936
LEMD30.935
APPBP20.935
FBXO30.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.658
OR4F29-0.621
MTRNR2L6-0.302
MTRNR2L10-0.3
CSAG1-0.292
MTRNR2L9-0.292
MTRNR2L2-0.264
KLRB1-0.261
TTLL10-0.258
MTRNR2L8-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of CUL4B mRNA"20453058
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CUL4B mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL4B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CUL4B mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CUL4B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CUL4B gene27153756
D000393Air PollutantsAir Pollutants results in decreased expression of CUL4B mRNA25056781
D001280AtrazineAtrazine results in decreased expression of CUL4B mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CUL4B mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUL4B mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of CUL4B mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CUL4B mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CUL4B mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CUL4B mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CUL4B gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CUL4B mRNA19376846
D003042CocaineCocaine results in increased expression of CUL4B mRNA15009677
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of CUL4B mRNA21878529
D003907DexamethasoneDexamethasone results in increased expression of CUL4B mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CUL4B mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of CUL4B mRNA18042831
D005472FluorouracilFluorouracil results in increased expression of CUL4B protein16803524
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CUL4B gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CUL4B mRNA23649840
C492448ICG 001ICG 001 results in increased expression of CUL4B mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CUL4B mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL4B mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CUL4B mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of CUL4B mRNA20003209
D008628MercuryMercury analog results in decreased expression of CUL4B mRNA25056781
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CUL4B gene20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of CUL4B mRNA21061450
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CUL4B mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CUL4B mRNA27544571
C029938nickel sulfatenickel sulfate results in decreased expression of CUL4B mRNA16100012
D000073878Palm OilPalm Oil results in decreased expression of CUL4B mRNA18042831
D010795Phthalic AcidsPhthalic Acids results in increased expression of CUL4B mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of CUL4B mRNA17426115|1830175
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of CUL4B mRNA]21318169
D010894PiroxicamPiroxicam results in decreased expression of CUL4B mRNA21858171
D011794QuercetinQuercetin results in decreased expression of CUL4B mRNA21632981
D011794QuercetinQuercetin results in increased expression of CUL4B mRNA14715546
D012524SarinSarin results in decreased expression of CUL4B mRNA19522546
D012524SarinSarin results in increased expression of CUL4B mRNA19522546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUL4B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CUL4B mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL4B mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL4B mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CUL4B mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of CUL4B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CUL4B mRNA23179753|2519280

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA bindingcontributes_toIDA22334663  
GO:0005515protein binding-IPI12609982  16949367  16964240  17041588  18775313  19651607  
21778237  22466964  22939624  23238014  25036637  25435324  
25910212  26496610  27107014  27173435  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0061630ubiquitin protein ligase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-NAS8681378  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006511ubiquitin-dependent protein catabolic process-IEA-  
GO:0010498proteasomal protein catabolic process-IDA25970626  
GO:0010498proteasomal protein catabolic process-IMP25970626  
GO:0016567protein ubiquitination-IMP28437394  
GO:0031175neuron projection development-IEA-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0035518histone H2A monoubiquitination-IDA22334663  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0045732positive regulation of protein catabolic process-IEA-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO:0070914UV-damage excision repair-IDA22334663  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA-  
GO:0031461cullin-RING ubiquitin ligase complex-IBA21873635  
GO:0031465Cul4B-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0031465Cul4B-RING E3 ubiquitin ligase complex-IDA18794347  21628527  22334663  
GO:0070062extracellular exosome-HDA19056867  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IDA16949367  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27974468Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. (2017 Feb 17)Jia LJ Biol Chem