Gene: SPIRE2

84501
Spir-2
spire type actin nucleation factor 2
protein-coding
16q24.3
Ensembl:ENSG00000204991 MIM:609217 Vega:OTTHUMG00000173039 UniprotKB:Q8WWL2
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  6.980e-2 (ND)   (Frontal_Cortex)
6.459e-1 (AD)  2.579e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2293585chr16:89822445 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03036210chr16:89904091SPIRE25.860e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPTBN40.956
LZTS30.952
LPCAT40.95
AP3B20.943
KATNB10.942
GRIN10.942
RAPGEFL10.941
PRRT20.94
CACNG80.94
PNMA30.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI2-0.568
WWTR1-0.561
REST-0.556
RAI14-0.548
SGMS2-0.536
YES1-0.525
OR4F5-0.519
KIAA0040-0.511
SEPT10-0.508
CNN2-0.505

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08080LATRUNCULIN BSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SPIRE2 mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SPIRE2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of SPIRE2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of SPIRE2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SPIRE2 gene27153756
D001151ArsenicArsenic affects the methylation of SPIRE2 gene25304211
D001280AtrazineAtrazine results in decreased expression of SPIRE2 mRNA25929836
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of SPIRE2 mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of SPIRE2 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPIRE2 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPIRE2 gene20938992
C480342clothianidinclothianidin results in decreased expression of SPIRE2 mRNA29044138
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of SPIRE2 mRNA26033743
D003300CopperCopper deficiency results in increased expression of SPIRE2 mRNA26033743
D003375CoumestrolCoumestrol results in decreased expression of SPIRE2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of SPIRE2 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of SPIRE2 promoter27989131
D004041Dietary FatsDietary Fats results in increased expression of SPIRE2 mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of SPIRE2 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of SPIRE2 mRNA26033743
C024629dimethyl phthalatedimethyl phthalate affects the expression of SPIRE2 mRNA26924002
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPIRE2 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPIRE2 gene20938992
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SPIRE2 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPIRE2 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SPIRE2 gene20938992
D010936Plant ExtractsPlant Extracts results in decreased expression of SPIRE2 mRNA23557933
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SPIRE2 mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPIRE2 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SPIRE2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SPIRE2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SPIRE2 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of SPIRE2 mRNA23411599
D014212TretinoinTretinoin results in increased expression of SPIRE2 mRNA20488242
D014635Valproic AcidValproic Acid results in increased methylation of SPIRE2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SPIRE2 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0016192vesicle-mediated transport-ISS-  
GO:0030036actin cytoskeleton organization-IMP21620703  
GO:0036089cleavage furrow formation-ISS-  
GO:0040038polar body extrusion after meiotic divisions-ISS-  
GO:0045010actin nucleation-IEA-  
GO:0046907intracellular transport-ISS-  
GO:0051295establishment of meiotic spindle localization-IMP21620703  
GO:0070649formin-nucleated actin cable assembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005938cell cortex-ISS-  
GO:0030659cytoplasmic vesicle membrane-ISS-  
GO:0032154cleavage furrowcolocalizes_withISS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal