Gene: CUL4A

8451
-
cullin 4A
protein-coding
13q34
Ensembl:ENSG00000139842 MIM:603137 Vega:OTTHUMG00000017384 UniprotKB:Q13619
NC_000013.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.783e-1 (AD)  4.247e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX50.923
PRPF4B0.917
DDX180.912
SF3B10.909
UBXN40.908
PPP6C0.904
XRN20.902
RIOK30.901
RBM390.9
SMARCA50.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.703
OR4F29-0.691
OR4F16-0.206
MTRNR2L9-0.189
RSPO1-0.18
SPRR2D-0.173
MTRNR2L6-0.172
MTRNR2L10-0.172
HMHB1-0.159
RNF223-0.155

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of CUL4A mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of CUL4A mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CUL4A mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of CUL4A mRNA21298039
D001554BenzeneBenzene results in increased expression of CUL4A mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CUL4A mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUL4A mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of CUL4A mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CUL4A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CUL4A mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of CUL4A mRNA25181051
C025703bleomycetinbleomycetin results in increased expression of CUL4A mRNA21040473
C013418bromfenacoumbromfenacoum results in increased expression of CUL4A protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CUL4A mRNA15336504
C459604candoxincandoxin results in decreased expression of CUL4A mRNA16309724
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CUL4A mRNA20938992
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of CUL4A mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of CUL4A mRNA21878529
D016572CyclosporineCyclosporine results in decreased expression of CUL4A mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CUL4A mRNA20106945
D003703DemecolcineDemecolcine results in increased expression of CUL4A mRNA23649840
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CUL4A mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of CUL4A mRNA26924002
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CUL4A mRNA23649840
D005472FluorouracilCUL4A protein affects the susceptibility to Fluorouracil16467204
D005485FlutamideFlutamide results in decreased expression of CUL4A mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CUL4A mRNA20938992
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of CUL4A mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CUL4A mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of CUL4A mRNA18927307
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CUL4A mRNA23430699
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CUL4A mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CUL4A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CUL4A mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CUL4A mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CUL4A promoter"26251327
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CUL4A mRNA26924002
C017096n-butoxyethanoln-butoxyethanol results in increased expression of CUL4A mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CUL4A mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of CUL4A mRNA23091169
C030299phenylhydrazineCUL4A protein affects the susceptibility to phenylhydrazine16467204
D010672PhenytoinPhenytoin results in increased expression of CUL4A mRNA20345932
D010936Plant ExtractsPlant Extracts results in increased expression of CUL4A mRNA23557933
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CUL4A mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of CUL4A gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUL4A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CUL4A mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CUL4A mRNA25613284
D019772TopotecanCUL4A protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CUL4A mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CUL4A mRNA17218384
D014415TunicamycinTunicamycin results in decreased expression of CUL4A mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of CUL4A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CUL4A mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of CUL4A gene29154799
D014750VincristineVincristine results in increased expression of CUL4A mRNA23649840
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CUL4A mRNA19244175
D014810Vitamin EVitamin E results in increased expression of CUL4A mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of CUL4A mRNA20044591
C088658zoledronic acidzoledronic acid results in increased expression of CUL4A mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12504025  12504026  12609982  14739464  16473935  16949367  
16964240  17041588  18775313  19966799  21113133  21778237  
22157821  22466964  26496610  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0061630ubiquitin protein ligase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS8681378  
GO:0000715nucleotide-excision repair, DNA damage recognition-TAS-  
GO:0001701in utero embryonic development-IEA-  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0007050cell cycle arrest-TAS8681378  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008285negative regulation of cell proliferation-TAS8681378  
GO:0016032viral process-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0016567protein ubiquitination-IMP28437394  
GO:0030097hemopoiesis-IEA-  
GO:0030853negative regulation of granulocyte differentiation-IEA-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0042769DNA damage response, detection of DNA damage-TAS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IMP14739464  
GO:0043687post-translational protein modification-TAS-  
GO:0051246regulation of protein metabolic process-IEA-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO:0097193intrinsic apoptotic signaling pathway-TAS8681378  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IEA-  
GO:2000001regulation of DNA damage checkpoint-IEA-  
GO:2000819regulation of nucleotide-excision repair-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0031461cullin-RING ubiquitin ligase complex-IBA21873635  
GO:0031464Cul4A-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0031464Cul4A-RING E3 ubiquitin ligase complex-IDA12732143  14739464  17085480  18794347  20129063  20223979  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0080008Cul4-RING E3 ubiquitin ligase complex-IDA16949367  18381890  
KEGG ID KEGG Term
hsa03420Nucleotide excision repair
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-110314Recognition of DNA damage by PCNA-containing replication complexTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5696394DNA Damage Recognition in GG-NERTAS
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS
R-HSA-8951664NeddylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27974468Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer. (2017 Feb 17)Jia LJ Biol Chem