Gene: CUL3

8452
CUL-3|PHA2E
cullin 3
protein-coding
2q36.2
Ensembl:ENSG00000036257 MIM:603136 Vega:OTTHUMG00000133167 UniprotKB:Q13618
NG_032169.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.325e-1 (AD)  2.659e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB140.966
NARS0.966
UBQLN10.965
ARL8B0.964
RAD23B0.964
CAND10.962
CLTC0.962
PPP2R5E0.96
GRSF10.959
TAX1BP10.958

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.598
CSAG1-0.381
VNN3-0.326
KLRB1-0.316
MTRNR2L10-0.316
MTRNR2L9-0.306
MTRNR2L6-0.305
MAGEA12-0.3
ANPEP-0.295

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CUL3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CUL3 mRNA"21346803
C0229602-oxindole2-oxindole inhibits the reaction [CUL3 protein binds to KEAP1 protein]22245129
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]18417180
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of CUL3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CUL3 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CUL3 mRNA20504355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUL3 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased methylation of CUL3 gene28582417
C006780bisphenol Abisphenol A results in increased expression of CUL3 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of CUL3 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of CUL3 mRNA17659339
D019256Cadmium ChlorideCadmium Chloride affects the expression of CUL3 mRNA18804290
D002220CarbamazepineCarbamazepine affects the expression of CUL3 mRNA24752500
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CUL3 mRNA23650126
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CUL3 mRNA21356183
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of CUL3 protein23453443
D003976DiazinonDiazinon affects the expression of CUL3 mRNA22546817
D004008DiclofenacDiclofenac affects the expression of CUL3 mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of CUL3 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of CUL3 mRNA]19030233
D002117CalcitriolCalcitriol results in increased expression of CUL3 mRNA16002434
C024629dimethyl phthalatedimethyl phthalate affects the expression of CUL3 mRNA26924002
D004281Docosahexaenoic AcidsDocosahexaenoic Acids inhibits the reaction [KEAP1 protein binds to CUL3 protein]25742418
C118739entinostatentinostat results in decreased expression of CUL3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C039281furanfuran results in decreased methylation of CUL3 gene22079235
D005839GentamicinsGentamicins results in increased expression of CUL3 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of CUL3 mRNA28973697
C544151jinfukangjinfukang results in decreased expression of CUL3 mRNA27392435
C410337K 7174K 7174 results in increased expression of CUL3 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of CUL3 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CUL3 mRNA21641980
D008558MelphalanMelphalan results in increased expression of CUL3 mRNA22363485
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CUL3 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of CUL3 mRNA22129749
C406082monomethylarsonous acidmonomethylarsonous acid promotes the reaction [KEAP1 protein binds to CUL3 protein]18417180
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CUL3 mRNA26924002
C437683motexafin gadoliniummotexafin gadolinium results in decreased expression of CUL3 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA16357179
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CUL3 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of CUL3 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CUL3 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of CUL3 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of CUL3 mRNA23012394
D011748PyrogallolPyrogallol results in increased expression of CUL3 mRNA20362636
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of CUL3 mRNA]19030233
D012643SeleniumSelenium results in decreased expression of CUL3 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in increased expression of CUL3 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CUL3 mRNA19073995
C017947sodium arsenitesodium arsenite promotes the reaction [KEAP1 protein binds to CUL3 protein]18417180
C017947sodium arsenitesodium arsenite inhibits the reaction [[CUL3 protein binds to KEAP1 protein] which binds to and results in increased ubiquitination of NFE2L2 protein]16785233
C016104sodium bichromatesodium bichromate results in increased expression of CUL3 mRNA22155349
D012969Sodium FluorideSodium Fluoride results in increased expression of CUL3 protein28918527
C017719solanesolsolanesol inhibits the reaction [KEAP1 protein binds to CUL3 protein binds to RBX1 protein]25645596
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CUL3 mRNA21641980
C016766sulforafansulforafan inhibits the reaction [KEAP1 protein binds to CUL3 protein]18417180
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CUL3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CUL3 mRNA18691609
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CUL3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CUL3 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of CUL3 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CUL3 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of CUL3 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CUL3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of CUL3 mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of CUL3 mRNA18930951
D014810Vitamin EVitamin E results in decreased expression of CUL3 mRNA19244175
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA16357179
D019345Zinc AcetateZinc Acetate results in decreased expression of CUL3 mRNA16357179
C016837zinc chloridezinc chloride results in increased expression of CUL3 mRNA16973896

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activitycontributes_toIDA15983046  19261606  19782033  20389280  
GO:0005112Notch binding-IPI25401743  
GO:0005515protein binding-IPI12609982  18397884  18573101  18775313  18826954  19261606  
19427028  19617556  20389280  21577200  21778237  21828050  
21988832  22466964  22748208  22939624  23563313  23665031  
23776465  25270598  25416956  26334369  27152988  27561354  
GO:0030332cyclin binding-IEA-  
GO:0031208POZ domain binding-IDA19261606  
GO:0031625ubiquitin protein ligase binding-IBA21873635  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO:0061630ubiquitin protein ligase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS8681378  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0000165MAPK cascade-TAS-  
GO:0000209protein polyubiquitination-IDA19261606  
GO:0001831trophectodermal cellular morphogenesis-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-IDA25401743  27561354  
GO:0006513protein monoubiquitination-IDA22358839  
GO:0006888ER to Golgi vesicle-mediated transport-IDA22358839  
GO:0007050cell cycle arrest-TAS8681378  
GO:0007080mitotic metaphase plate congression-IMP17543862  19995937  
GO:0007229integrin-mediated signaling pathway-ISS-  
GO:0007369gastrulation-IEA-  
GO:0008284positive regulation of cell proliferation-TAS9733711  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016477cell migration-IMP19782033  
GO:0016567protein ubiquitination-IDA17543862  19782033  19995937  20389280  
GO:0017145stem cell division-ISS-  
GO:0030030cell projection organization-IEA-  
GO:0031145anaphase-promoting complex-dependent catabolic process-IDA10500095  
GO:0031398positive regulation of protein ubiquitination-IGI24844779  
GO:0031648protein destabilization-IGI24844779  
GO:0032467positive regulation of cytokinesis-IMP19261606  
GO:0035024negative regulation of Rho protein signal transduction-IMP19782033  
GO:0040016embryonic cleavage-ISS-  
GO:0043149stress fiber assembly-IMP19782033  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IDA19261606  19782033  20389280  
GO:0043687post-translational protein modification-TAS-  
GO:0044346fibroblast apoptotic process-IEA-  
GO:0045842positive regulation of mitotic metaphase/anaphase transition-IMP17543862  
GO:0048208COPII vesicle coating-IMP22358839  
GO:0071630nuclear protein quality control by the ubiquitin-proteasome system-IDA27561354  
GO:0072576liver morphogenesis-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS-  
GO:0097193intrinsic apoptotic signaling pathway-TAS8681378  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA28395323  
GO:0005827polar microtubule-IDA19995937  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0031461cullin-RING ubiquitin ligase complex-IBA21873635  
GO:0031463Cul3-RING ubiquitin ligase complex-IDA15983046  17543862  19158078  19261606  19782033  19995937  20389280  22358839  22578813  23453970  23455478  23576762  24768539  26399832  
GO:0036126sperm flagellum-IDA28395323  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168256Immune SystemTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-5358351Signaling by HedgehogTAS
R-HSA-5632684Hedgehog 'on' stateTAS
R-HSA-5658442Regulation of RAS by GAPsTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18757741Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. (2008 Sep 9)Shibata TProc Natl Acad Sci U S A