Gene: ACSS1

84532
ACAS2L|ACECS1|AceCS2L
acyl-CoA synthetase short chain family member 1
protein-coding
20p11.21
Ensembl:ENSG00000154930 MIM:614355 Vega:OTTHUMG00000032112 UniprotKB:Q9NUB1
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.555e-1 (AD)  9.984e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8114108chr20:25051439 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGFR30.931
GPR37L10.926
BMP70.9
PRODH0.891
GRIN2C0.886
SELENBP10.883
MLC10.878
PSD20.874
KCNJ100.87
PRDM160.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FER1L6-0.381
OR4F5-0.377
GADL1-0.352
GALR1-0.349
FGF10-0.349
CD163L1-0.347
GSDMA-0.346
SYNPO2-0.346
CITED1-0.343
KLK8-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ACSS1 mRNA"25614096
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of ACSS1 mRNA"20816883
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ACSS1 mRNA25704631|2906747
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of ACSS1 mRNA28959563
C015001arsenitearsenite results in increased methylation of ACSS1 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSS1 mRNA22610609
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACSS1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of ACSS1 mRNA15289156
C006780bisphenol Abisphenol A affects the methylation of ACSS1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of ACSS1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ACSS1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ACSS1 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ACSS1 mRNA20938992
D003042CocaineCocaine results in decreased expression of ACSS1 mRNA27899881
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ACSS1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of ACSS1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ACSS1 mRNA26577399|2752363
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ACSS1 mRNA24317228
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ACSS1 mRNA]27941970
D064730DexrazoxaneDexrazoxane results in decreased expression of ACSS1 mRNA26873546
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACSS1 mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ACSS1 mRNA17361019|2126653
D004041Dietary FatsDietary Fats results in increased expression of ACSS1 mRNA18042831
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA22129741
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ACSS1 mRNA15289156
D004237DiuronDiuron results in decreased expression of ACSS1 mRNA21551480
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ACSS1 mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of ACSS1 mRNA26873546
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ACSS1 mRNA20938992
D019833GenisteinGenistein results in increased expression of ACSS1 mRNA15289156
D005839GentamicinsGentamicins results in increased expression of ACSS1 mRNA22061828
C010974glyphosateglyphosate results in increased expression of ACSS1 mRNA25636363
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ACSS1 mRNA20044591
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA22129741
C544151jinfukangjinfukang results in increased expression of ACSS1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of ACSS1 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of ACSS1 mRNA16807920
D007854LeadLead results in decreased expression of ACSS1 mRNA19921347
C045463leflunomideleflunomide results in decreased expression of ACSS1 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ACSS1 mRNA20938992
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ACSS1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACSS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACSS1 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ACSS1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ACSS1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ACSS1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of ACSS1 mRNA18042831
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of ACSS1 mRNA21705711
C006253pirinixic acidpirinixic acid results in increased expression of ACSS1 mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of ACSS1 mRNA23012394|2301818
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACSS1 mRNA24780913
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ACSS1 mRNA21427059
D012906SmokeSmoke affects the expression of ACSS1 mRNA23693141
D053260SootSoot results in decreased expression of ACSS1 mRNA22461453
D013739TestosteroneTestosterone results in decreased expression of ACSS1 mRNA20403060
C009495titanium dioxidetitanium dioxide results in decreased expression of ACSS1 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACSS1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ACSS1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ACSS1 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACSS1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of ACSS1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACSS1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ACSS1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ACSS1 mRNA21427059
D014640VancomycinVancomycin results in increased expression of ACSS1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ACSS1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of ACSS1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of ACSS1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003987acetate-CoA ligase activity-EXP16788062  
GO:0003987acetate-CoA ligase activity-IDA16788062  
GO:0005515protein binding-IPI16788062  19535340  25416956  
GO:0005524ATP binding-IEA-  
GO:0016208AMP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006069ethanol oxidation-TAS-  
GO:0006085acetyl-CoA biosynthetic process-IDA16788062  
GO:0019413acetate biosynthetic process-IEA-  
GO:0019427acetyl-CoA biosynthetic process from acetate-IEA-  
GO:0019542propionate biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-IDA16788062  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal