Gene info: ID 84561

SNP ID	Position	Alleles	Trait	Variation Type
rs6763338	chr3:125168389 (GRCh38.p7)	C>A	nicotine dependence	SNV(Single Nucleotide Variation)

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg11034122	chr3:124879970	SLC12A8		7.670e-11	Alcohol consumption per day	27843151

Gene Symbol	Pearson Correlation Coefficient
CDK20	0.812
ICAM5	0.8
SIPA1L1	0.798
PDE1B	0.797
KIAA1211L	0.793
CAMKK1	0.786
PTK2B	0.784
JPH1	0.784
WIPF3	0.783
NEDD4L	0.783

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.433
CTNNA3	-0.418
SH2D1A	-0.413
RAI14	-0.405
MBNL3	-0.403
ANXA13	-0.403
COPZ2	-0.403
YES1	-0.392
NEK7	-0.391
BCAS1	-0.386

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of SLC12A8 mRNA	25596134
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC12A8 mRNA"	25510870
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SLC12A8 mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC12A8 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC12A8 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC12A8 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC12A8 mRNA"	25510870
D000082	Acetaminophen	Acetaminophen results in decreased expression of SLC12A8 mRNA	29067470
D020106	Acrylamide	Acrylamide results in increased expression of SLC12A8 mRNA	28959563
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SLC12A8 mRNA	16483693
D004958	Estradiol	Estradiol results in decreased expression of SLC12A8 mRNA	19167446
C006780	bisphenol A	bisphenol A results in increased expression of SLC12A8 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of SLC12A8 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SLC12A8 mRNA	25596134
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC12A8 mRNA	20360939
C004656	chloroacetaldehyde	chloroacetaldehyde affects the expression of SLC12A8 mRNA	25596134
D002746	Chlorpromazine	Chlorpromazine results in increased expression of SLC12A8 mRNA	25596134
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC12A8 mRNA	20938992
C059262	cidofovir	cidofovir affects the expression of SLC12A8 mRNA	25596134
D004002	Clodronic Acid	Clodronic Acid results in decreased expression of SLC12A8 mRNA	25596134
D003042	Cocaine	Cocaine affects the expression of SLC12A8 mRNA	20187946
D003042	Cocaine	Cocaine results in decreased expression of SLC12A8 mRNA	27899881
D003300	Copper	Copper deficiency results in increased expression of SLC12A8 mRNA	26033743
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SLC12A8 mRNA"	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of SLC12A8 mRNA	19167446
D003471	Cuprizone	Cuprizone results in decreased expression of SLC12A8 mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC12A8 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of SLC12A8 mRNA	25596134
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of SLC12A8 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SLC12A8 mRNA	25596134
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of SLC12A8 mRNA	26033743
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SLC12A8 mRNA	20360939
C118739	entinostat	entinostat results in increased expression of SLC12A8 mRNA	27188386
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC12A8 mRNA	20938992
C069837	fullerene C60	fullerene C60 results in increased expression of SLC12A8 mRNA	19167457
C039281	furan	furan results in increased expression of SLC12A8 mRNA	25539665\|2738771
C004312	glycidol	glycidol results in decreased expression of SLC12A8 mRNA	24915197
D006861	Hydrogen Peroxide	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein	18951874
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SLC12A8 mRNA	18951874
C492448	ICG 001	ICG 001 results in increased expression of SLC12A8 mRNA	26191083
D007069	Ifosfamide	Ifosfamide results in decreased expression of SLC12A8 mRNA	25596134
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of SLC12A8 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of SLC12A8 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SLC12A8 mRNA	26752646
C008261	lead acetate	lead acetate results in increased expression of SLC12A8 mRNA	22839698
D008687	Metformin	Metformin results in increased expression of SLC12A8 mRNA	25596134
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC12A8 mRNA	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of SLC12A8 mRNA	26011545
C043243	methyl tert-butyl ether	methyl tert-butyl ether affects the expression of SLC12A8 mRNA	24128854
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of SLC12A8 mRNA	22401849
D009532	Nickel	Nickel results in increased expression of SLC12A8 mRNA	25583101
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC12A8 mRNA	27935865
D010100	Oxygen	Oxygen deficiency results in decreased expression of SLC12A8 mRNA	25596134
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC12A8 mRNA"	25510870
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of SLC12A8 mRNA	26705709
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of SLC12A8 mRNA	22714537
D011441	Propylthiouracil	Propylthiouracil affects the expression of SLC12A8 mRNA	24780913
C089730	rosiglitazone	rosiglitazone results in increased expression of SLC12A8 mRNA	25596134
D012834	Silver	Silver results in increased expression of SLC12A8 mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in increased expression of SLC12A8 mRNA	22714537
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SLC12A8 mRNA	21570461
D013806	Theophylline	[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SLC12A8 protein	18951874
C009495	titanium dioxide	titanium dioxide results in decreased expression of SLC12A8 mRNA	23131501
C057693	troglitazone	troglitazone results in increased expression of SLC12A8 mRNA	25596134
D014635	Valproic Acid	Valproic Acid affects the expression of SLC12A8 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SLC12A8 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of SLC12A8 mRNA	23179753\|2718838
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SLC12A8 gene	25560391
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC12A8 mRNA	27935865

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006884	cell volume homeostasis	-	IBA	21873635
GO:0010107	potassium ion import	-	IBA	21873635
GO:0055064	chloride ion homeostasis	-	IBA	21873635
GO:0055075	potassium ion homeostasis	-	IBA	21873635
GO:0071805	potassium ion transmembrane transport	-	IEA	-
GO:1902476	chloride transmembrane transport	-	IBA	21873635

Gene: SLC12A8

ANCO-SNPs

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)