Gene: COL25A1

84570
AMY|CFEOM5|CLAC|CLAC-P|CLACP
collagen type XXV alpha 1 chain
protein-coding
4q25
Ensembl:ENSG00000188517 MIM:610004 Vega:OTTHUMG00000150039 UniprotKB:Q9BXS0
NG_047204.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.267e-2 (AD)  6.886e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6857726chr4:109273128 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11165912chr4:110220063COL25A17.500e-14Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLRA20.836
TENM10.826
FSTL50.816
ROBO20.798
GABRG30.792
C8orf340.791
KIAA10240.791
CDH70.788
PPM1E0.787
GRIN3A0.783

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.554
HIGD1B-0.465
ROM1-0.46
ANPEP-0.457
FITM1-0.453
NFE2-0.451
RNF135-0.449
IMPA2-0.446
SYDE1-0.444
MEF2B-0.438

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of COL25A1 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of COL25A1 mRNA24449571
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of COL25A1 mRNA29097150
C001277geldanamycingeldanamycin results in increased expression of COL25A1 mRNA26705709
D007854LeadLead affects the expression of COL25A1 mRNA28903495
D008694MethamphetamineMethamphetamine results in decreased expression of COL25A1 mRNA26307267
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of COL25A1 mRNA22401849
C009277sodium arsenatesodium arsenate results in increased expression of COL25A1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of COL25A1 mRNA25879800
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of COL25A1 mRNA26377647
D014212TretinoinTretinoin results in increased expression of COL25A1 mRNA21934132
D014635Valproic AcidValproic Acid results in increased expression of COL25A1 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of COL25A1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IDA11927537  15215182  15522881  15615705  
GO:0005201extracellular matrix structural constituent-IBA21873635  
GO:0008201heparin binding-IBA21873635  
GO:0008201heparin binding-IDA15522881  
GO ID GO Term Qualifier Evidence PubMed
GO:0030198extracellular matrix organization-IBA21873635  
GO:0060385axonogenesis involved in innervation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA11927537  
GO:0005576extracellular region-TAS-  
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11927537  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA11927537  
GO:0016021integral component of membrane-NAS11927537  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-8948216Collagen chain trimerizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal