Gene: CASR

846
CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1|hCasR
calcium sensing receptor
protein-coding
3q13.33-q21.1
Ensembl:ENSG00000036828 MIM:601199 UniprotKB:P41180
NG_009058.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.925e-2 (AD)  4.467e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNTN0.505
UGT1A60.496
LINC004230.495
OR8B20.489
EVX20.483
ADGB0.481
OR52B40.476
TRIM490.473
PAX40.472
C15orf320.471

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NWD1-0.327
EMX2-0.296
ACSS1-0.293
MYO10-0.281
GPR37L1-0.28
EYA2-0.277
ACACB-0.275
PLIN4-0.273
LRP4-0.273
SOX13-0.272

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00127SpermineSmall Molecule71-44-3Approved|NutraceuticalTarget
DB00994NeomycinSmall Molecule1404-04-2ApprovedTarget
DB01012CinacalcetSmall Molecule226256-56-0ApprovedTarget
DB05255RonacaleretSmall Molecule753449-67-1InvestigationalTarget
DB05695NPS-2143Small Molecule284035-33-2InvestigationalTarget
DB11093Calcium CitrateSmall Molecule813-94-5ApprovedTarget
DB11348Calcium PhosphateSmall Molecule10103-46-5ApprovedTarget
DB12865EtelcalcetideSmall Molecule1262780-97-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0631591-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium]"21562303
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]17041782
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]17041782
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium]19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ACTA2 mRNA]19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of COL1A1 mRNA]19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ICAM1 mRNA]19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of IL1B mRNA]19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of TNF mRNA]19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] which results in decreased susceptibility to Nickel19781536
C5693552-quinoxaline-carboxamide-N-adamantan-1-yl2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein19781536
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CASR gene27153756
D000535AluminumAluminum binds to and results in increased activity of CASR protein10231437
D000535Aluminum[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D000535Aluminum[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
C010845aluminum chloridealuminum chloride results in increased activity of CASR protein16316325
D017607Aluminum CompoundsAluminum Compounds results in decreased expression of CASR mRNA16316325
D000583AmikacinAmikacin results in increased activity of CASR protein19884751
D000639AmitriptylineAmitriptyline results in decreased expression of CASR mRNA22341215
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CASR mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CASR mRNA21839799
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]]17376781
D002118Calcium1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118Calcium"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [CASR protein results in increased uptake of Calcium]"21562303
D002118Calcium2-aminoethoxydiphenyl borate inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]17041782
D002118Calcium2-aminoethoxydiphenyl borate inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118Calcium[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium]19781536
D002118Calciumbisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]]17376781
D002118Calcium[Calcium binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium17041782
D002118CalciumCalcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein]17376781
D002118CalciumCalcium results in increased activity of CASR protein17041782
D002118CalciumCalcium results in increased phosphorylation of CASR protein17376781
D002118CalciumCASR gene mutant form results in increased susceptibility to Calcium11089548
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]24658506
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of KRT1 protein]24658506
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of LOR mRNA]24658506
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of LOR protein]24658506
D002118CalciumCASR mutant form inhibits the reaction [Calcium results in increased expression of WNT5A protein]24658506
D002118CalciumCASR protein affects the reaction [Nickel results in increased abundance of Calcium]19781536
D002118CalciumCASR protein mutant form results in decreased susceptibility to Calcium9011580
D002118CalciumCASR protein mutant form results in increased susceptibility to Calcium11701698|7874174
D002118Calcium"[CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate"7874174
D002118CalciumCASR protein promotes the reaction [TRPC6 protein results in increased uptake of Calcium]21562303
D002118CalciumCASR protein results in increased uptake of Calcium21562303
D002118Calciumchelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118CalciumFlufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118CalciumLanthanum inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]17041782
D002118CalciumLanthanum inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118Calciummethyl-beta-cyclodextrin inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118CalciumN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine affects the reaction [CASR gene mutant form results in increased susceptibility to Calcium]11089548
D002118CalciumN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine promotes the reaction [CASR protein results in increased susceptibility to Calcium]11089548
D002118CalciumNPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]17376781
D002118CalciumPertussis Toxin inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002118Calcium[Spermine binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium17041782
D002118Calcium[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D002118CalciumCalcium affects the expression of CASR mRNA15788476
D002118CalciumCalcium affects the expression of CASR protein15788476
D002118CalciumCalcium binds to and results in increased activity of CASR protein10231437|1107189
D002118Calcium[Calcium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D002118Calcium[Calcium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D002118Calcium[Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D002118CalciumGadolinium inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]10231437
D002118Calcium[Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D002118Calcium[Neomycin binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D002118CalciumCalcitriol inhibits the reaction [Calcium results in decreased expression of CASR mRNA]10048583
D002118CalciumCalcium binds to and results in increased activity of CASR protein7806584
D002118CalciumCalcium results in decreased expression of CASR mRNA10048583
D002122Calcium ChlorideCalcium Chloride promotes the reaction [Calcium results in increased phosphorylation of CASR protein]17376781
D002122Calcium ChlorideCalcium Chloride results in increased activity of CASR protein16316325
C059041calyculin A[phorbolol myristate acetate co-treated with calyculin A] results in increased phosphorylation of CASR protein17376781
C059041calyculin Acalyculin A promotes the reaction [phorbolol myristate acetate results in increased phosphorylation of CASR protein]17376781
C016299chelerythrinechelerythrine inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of CASR mRNA18636392
D000069449Cinacalcet HydrochlorideCinacalcet Hydrochloride affects the activity of CASR protein19560849
D003471CuprizoneCuprizone results in decreased expression of CASR mRNA27523638
D003471CuprizoneCuprizone results in increased expression of CASR mRNA26577399
C007262deoxynivalenolCASR affects the reaction [deoxynivalenol results in increased secretion of CCK protein]25787141
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CASR mRNA15620428
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CASR mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of CASR mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of CASR mRNA15788476
D002117CalcitriolCalcitriol results in increased expression of CASR protein15788476
D002117CalcitriolCalcitriol inhibits the reaction [Calcium results in decreased expression of CASR mRNA]10048583
C024629dimethyl phthalatedimethyl phthalate affects the expression of CASR mRNA26924002
D005439Flufenamic AcidFlufenamic Acid promotes the reaction [CASR protein results in increased uptake of Calcium]21562303
D005682GadoliniumGadolinium binds to and results in increased activity of CASR protein10231437|1107189
D005682Gadolinium[Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D005682Gadolinium[Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D005682GadoliniumGadolinium inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]10231437
D005682GadoliniumGadolinium binds to and results in increased activity of CASR protein7806584
D005839GentamicinsCASR protein promotes the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK1 protein]17537980
D005839GentamicinsCASR protein promotes the reaction [Gentamicins results in increased phosphorylation of and results in increased activity of MAPK3 protein]17537980
D005839GentamicinsGentamicins binds to and results in increased activity of CASR protein17537980
D005839GentamicinsGentamicins results in increased expression of CASR protein16850027
D007295Inositol Phosphates[Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D007295Inositol Phosphates[Calcium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D007295Inositol Phosphates[Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D007295Inositol Phosphates[Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D007295Inositol Phosphates[Neomycin binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D007538IsoniazidIsoniazid affects the expression of CASR mRNA20623750
D007811LanthanumLanthanum inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]17041782
D007811LanthanumLanthanum inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D007811LanthanumLanthanum inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]17041782
D008274MagnesiumCASR protein results in increased susceptibility to Magnesium15068510
D008274MagnesiumMagnesium binds to and results in increased activity of CASR protein10231437
D008274Magnesium[Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D008274Magnesium[Magnesium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D008274MagnesiumMagnesium results in increased expression of CASR mRNA11563847
D008274MagnesiumMagnesium results in increased expression of CASR protein11563847
D008727MethotrexateMethotrexate results in decreased expression of CASR mRNA24449571
C108732methyl-beta-cyclodextrinmethyl-beta-cyclodextrin inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CASR mRNA23103053
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CASR mRNA26924002
D015544Inositol 1,4,5-Trisphosphate"[CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate"7874174
C558527N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide"N-(1-ethyl-1-(4-methylphenyl)propyl)-7,7-dimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrimidine-3-carboxamide binds to and results in decreased activity of CASR protein"21306167
C107873N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamineN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine affects the reaction [CASR gene mutant form results in increased susceptibility to Calcium]11089548
C107873N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamineN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine promotes the reaction [CASR protein results in increased susceptibility to Calcium]11089548
C107873N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamineCASR protein results in increased susceptibility to N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine15068510
C107873N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamineN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine results in increased expression of CASR mRNA19092814
C107873N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamineN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine results in increased expression of CASR protein19092814
C107873N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamineN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine binds to and results in increased activity of CASR protein27667315
C436740N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine"N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine binds to and results in decreased activity of CASR protein"27667315
D009355NeomycinCASR protein promotes the reaction [Neomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]17537980
D009355NeomycinCASR protein promotes the reaction [Neomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]17537980
D009355NeomycinNeomycin binds to and results in increased activity of CASR protein17537980
D009355NeomycinNeomycin binds to and results in increased activity of CASR protein10231437
D009355Neomycin[Neomycin binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium10231437
D009355Neomycin[Neomycin binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates10231437
D009355NeomycinNeomycin binds to and results in increased activity of CASR protein7806584
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased abundance of Calcium]19781536
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ACTA2 mRNA]19781536
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of COL1A1 mRNA]19781536
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of ICAM1 mRNA]19781536
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of IL1B mRNA]19781536
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] inhibits the reaction [Nickel results in increased expression of TNF mRNA]19781536
D009532Nickel[2-quinoxaline-carboxamide-N-adamantan-1-yl binds to and results in decreased activity of CASR protein] which results in decreased susceptibility to Nickel19781536
D009532NickelCASR protein affects the reaction [Nickel results in increased abundance of Calcium]19781536
D009532NickelNickel results in increased activity of CASR protein19781536
C025256nonylphenolnonylphenol results in decreased expression of CASR mRNA15620428
C111654NPS R-467bisindolylmaleimide I inhibits the reaction [NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]]17376781
C111654NPS R-467NPS R-467 promotes the reaction [Calcium results in increased phosphorylation of CASR protein]17376781
C111654NPS R-467NPS R-467 results in decreased expression of CASR mRNA16164647
C111654NPS R-467NPS R-467 promotes the reaction [Spermine binds to and results in increased activity of CASR protein]11071898
C111654NPS R-467NPS R-467 binds to and results in increased activity of CASR protein15086907
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of CASR mRNA18636392
D000073878Palm OilPalm Oil results in decreased expression of CASR mRNA18042831
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [CASR protein results in increased uptake of Calcium]21562303
D010656PhenylephrinePhenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]11071898
C016658phorbolol myristate acetate[phorbolol myristate acetate co-treated with calyculin A] results in increased phosphorylation of CASR protein17376781
C016658phorbolol myristate acetatecalyculin A promotes the reaction [phorbolol myristate acetate results in increased phosphorylation of CASR protein]17376781
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased phosphorylation of CASR protein17376781
D010758PhosphorusCASR protein affects the abundance of Phosphorus11589681
D010936Plant ExtractsPlant Extracts results in decreased expression of CASR mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of CASR mRNA24780913
D011744PyrimidinonesPyrimidinones binds to and results in decreased activity of CASR protein20507089
D012969Sodium FluorideSodium Fluoride results in decreased expression of CASR mRNA21340527|2786293
D013096Spermine2-aminoethoxydiphenyl borate inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]17041782
D013096SpermineLanthanum inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]17041782
D013096SpermineSpermine binds to and results in increased activity of CASR protein17041782
D013096Spermine[Spermine binds to and results in increased activity of CASR protein] which results in increased uptake of Calcium17041782
D013096SpermineNPS R-467 promotes the reaction [Spermine binds to and results in increased activity of CASR protein]11071898
D013096SperminePhenylephrine inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]11071898
D013096SpermineSpermine binds to and results in increased activity of CASR protein11071898
D013096SpermineThapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]11071898
D013324StrontiumCASR protein results in increased susceptibility to Strontium15068510
D013324StrontiumStrontium affects the activity of CASR protein15068510
D013739TestosteroneTestosterone deficiency results in increased expression of CASR mRNA21045173
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in increased expression of CASR mRNA]21045173
D013739TestosteroneTestosterone results in decreased expression of CASR mRNA20403060
D019284ThapsigarginThapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]11071898
C057693troglitazonetroglitazone results in increased expression of CASR mRNA21515302
D014640VancomycinVancomycin results in increased expression of CASR mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CASR gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of CASR mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of CASR mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004435phosphatidylinositol phospholipase C activity-TAS7874174  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IDA27434672  
GO:0005178integrin binding-IEA-  
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA27434672  
GO:0005515protein binding-IPI20361938  
GO:0008144drug binding-IEA-  
GO:0016597amino acid binding-IDA27434672  
GO:0019808polyamine binding-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0042803protein homodimerization activity-IDA16740594  27434672  
GO:0044325ion channel binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001503ossification-IEA-  
GO:0002931response to ischemia-IEA-  
GO:0005513detection of calcium ion-IBA21873635  
GO:0005513detection of calcium ion-IDA27434672  
GO:0006874cellular calcium ion homeostasis-IBA21873635  
GO:0006874cellular calcium ion homeostasis-IDA27434672  
GO:0006915apoptotic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IDA27434672  
GO:0007186G-protein coupled receptor signaling pathway-IMP8636323  8702647  8878438  17555508  19789209  21566075  22789683  23169696  23966241  25104082  25292184  25766501  26386835  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IEA-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IEA-  
GO:0007254JNK cascade-IEA-  
GO:0007635chemosensory behavior-TAS7759551  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0009653anatomical structure morphogenesis-TAS7916660  
GO:0010628positive regulation of gene expression-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0032781positive regulation of ATPase activity-IEA-  
GO:0035729cellular response to hepatocyte growth factor stimulus-IEA-  
GO:0042311vasodilation-IEA-  
GO:0045907positive regulation of vasoconstriction-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:0050927positive regulation of positive chemotaxis-IEA-  
GO:0051924regulation of calcium ion transport-IBA21873635  
GO:0060613fat pad development-IEA-  
GO:0070509calcium ion import-IDA20846291  
GO:0071305cellular response to vitamin D-IEA-  
GO:0071333cellular response to glucose stimulus-IEA-  
GO:0071404cellular response to low-density lipoprotein particle stimulus-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:0071774response to fibroblast growth factor-IEA-  
GO:0090280positive regulation of calcium ion import-IEA-  
GO:1901653cellular response to peptide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA8702647  16740594  17555508  19789209  22789683  25104082  25766501  26386835  
GO:0009986cell surface-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
GO:0043679axon terminus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26514527Lung Cancer in a Rural Area of China: Rapid Rise in Incidence and Poor Improvement in Survival. (2015)Yang JAsian Pac J Cancer Prev
24624459Pancreatitis Overview (1993)LaRusch J-
25124570Parathyroid hormone gene rs6256 and calcium sensing receptor gene rs1801725 variants are not associated with susceptibility to colorectal cancer in Iran. (2014)Mahmoudi TAsian Pac J Cancer Prev
28920314Lung cancer incidence and mortality in China, 2008. (2013 Feb)Zeng HThorac Cancer
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
22608493[Chronic pancreatitis: beyond alcohol]. (2012 Oct)Vaquero Raya ECGastroenterol Hepatol
27761213Alanine to Serine Variant at Position 986 of Calcium Sensing Receptor and Colorectal Cancer Risk. (2016 Aug)Dabiri RIran J Cancer Prev