Gene: KLF11

8462
FKLF|FKLF1|MODY7|TIEG2|Tieg3
Kruppel like factor 11
protein-coding
2p25.1
Ensembl:ENSG00000172059 MIM:603301 Vega:OTTHUMG00000119004 UniprotKB:O14901
NG_017199.1
PubMed
0   ANCO-SNPs
AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.058e-1 (AD)  6.427e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20853880chr2:10184444KLF111.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FMNL30.76
PAQR50.749
EOGT0.734
VCL0.733
CD2AP0.727
CD460.725
CTTNBP2NL0.713
PODXL0.713
CHD10.711
KLF60.711

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.315
OR4F5-0.293
GHRH-0.224
HES5-0.223
NKX2-8-0.222
ASPDH-0.221
CFC1-0.218
HCRT-0.215
NANOS3-0.213
LYPD8-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF11 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF11 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF11 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF11 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF11 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of KLF11 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of KLF11 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of KLF11 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of KLF11 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KLF11 protein20106945
D0150812-Naphthylamine2-Naphthylamine results in increased expression of KLF11 mRNA18247414
C006632arsenic trioxidearsenic trioxide results in decreased expression of KLF11 mRNA15761015
D001280AtrazineAtrazine results in increased expression of KLF11 mRNA22982499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLF11 mRNA18247414
C044887beta-methylcholinebeta-methylcholine affects the expression of KLF11 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of KLF11 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of KLF11 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of KLF11 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of KLF11 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of KLF11 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KLF11 mRNA25912033
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of KLF11 protein25912033
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KLF11 gene20938992
D019327Copper SulfateCopper Sulfate results in increased expression of KLF11 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of KLF11 mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of KLF11 mRNA23640034
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of KLF11 mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of KLF11 mRNA28962523
D002945CisplatinCisplatin results in increased expression of KLF11 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of KLF11 mRNA16002434
D011345FenofibrateFenofibrate results in increased expression of KLF11 mRNA25572481
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KLF11 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of KLF11 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of KLF11 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of KLF11 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of KLF11 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of KLF11 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KLF11 mRNA24796395|2675264
C045463leflunomideleflunomide results in increased expression of KLF11 mRNA28988120
C042720mercuric bromidemercuric bromide results in decreased expression of KLF11 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KLF11 gene20938992
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of KLF11 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of KLF11 mRNA21195148
C028007nickel monoxidenickel monoxide results in decreased expression of KLF11 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of KLF11 mRNA22714537
D009538NicotineNicotine results in decreased expression of KLF11 mRNA18247414
D010100OxygenOxygen affects the reaction [AHR protein results in decreased expression of KLF11 mRNA]27103661
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of KLF11 mRNA"25510870
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of KLF11 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of KLF11 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of KLF11 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of KLF11 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLF11 mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of KLF11 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of KLF11 mRNA18301758|2527062
D010938Plant OilsPlant Oils results in increased expression of KLF11 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KLF11 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of KLF11 mRNA24780913
C059514resveratrolresveratrol results in decreased expression of KLF11 protein18089832
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KLF11 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of KLF11 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLF11 mRNA24058054
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of KLF11 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of KLF11 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KLF11 mRNA28065790
D019772TopotecanTopotecan results in decreased expression of KLF11 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of KLF11 mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLF11 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of KLF11 mRNA28973697
D014520UrethaneUrethane results in decreased expression of KLF11 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLF11 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of KLF11 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of KLF11 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of KLF11 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of KLF11 mRNA15901671
D014638VanadatesVanadates results in increased expression of KLF11 mRNA22714537
D014639VanadiumVanadium results in decreased expression of KLF11 mRNA19000753
D024483Vitamin K 3Vitamin K 3 affects the expression of KLF11 mRNA20044591
C111237vorinostatvorinostat results in decreased expression of KLF11 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of KLF11 mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of KLF11 mRNA20977926|2471476

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IDA21171965  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-TAS9748269  
GO:0005515protein binding-IPI25416956  
GO:0044212transcription regulatory region DNA binding-IDA21171965  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-IDA21171965  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA21171965  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9748269  
GO:0006915apoptotic process-IEA-  
GO:0008285negative regulation of cell proliferation-IDA21171965  
GO:0043065positive regulation of apoptotic process-IDA21171965  
GO:1901653cellular response to peptide-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-TAS9748269  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005925focal adhesion-IDA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25739536Chronic Social Stress and Ethanol Increase Expression of KLF11, a Cell Death Mediator, in Rat Brain. (2015 Jul)Duncan JNeurotox Res
22890201Monoamine oxidases in major depressive disorder and alcoholism. (2012 Jun)Duncan JDrug Discov Ther
23915421The expression of KLF11 (TIEG2), a monoamine oxidase B transcriptional activator in the prefrontal cortex of human alcohol dependence. (2014 Jan)Udemgba CAlcohol Clin Exp Res