Gene: GPR174

84636
FKSG79|GPCR17|LYPSR3
G protein-coupled receptor 174
protein-coding
Xq21.1
Ensembl:ENSG00000147138 MIM:300903 Vega:OTTHUMG00000021898 UniprotKB:Q9BXC1
NG_016565.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRABD2B0.579
ATP2A30.573
KCNMB10.572
BMX0.567
GATA60.553
PYHIN10.552
ECM20.548
PTGDR0.545
CASQ20.543
PTGER40.542

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PURG-0.336
RHCG-0.335
FEZF2-0.333
B3GALT1-0.324
LGI1-0.313
SOX15-0.311
FAM171B-0.304
CHST10-0.303
RS1-0.303
EFNA5-0.298

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006632arsenic trioxidearsenic trioxide results in decreased expression of GPR174 mRNA27829220
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of GPR174 mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of GPR174 mRNA25181051
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GPR174 mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GPR174 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GPR174 mRNA"25554681
C012526quercitrinquercitrin results in increased expression of GPR174 mRNA25193878

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0035025positive regulation of Rho protein signal transduction-IBA21873635  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24289805rs3827440, a nonsynonymous single nucleotide polymorphism within GPR174 gene in X chromosome, is associated with Graves' disease in Polish Caucasian population. (2014 Jan)Szymanski KTissue Antigens