Gene: SUPT3H

8464
SPT3|SPT3L
SPT3 homolog, SAGA and STAGA complex component
protein-coding
6p21.1
Ensembl:ENSG00000196284 MIM:602947 Vega:OTTHUMG00000014773 UniprotKB:O75486
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
5.079e-1 (AD)  1.416e-1 (ND)   (Frontal_Cortex)
2.615e-1 (AD)  1.823e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9463046chr6:44834981 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUBP10.78
MAP3K70.775
GOPC0.773
DIDO10.772
EXOC20.772
PGS10.772
RPE0.769
SUPT7L0.767
CSE1L0.763
TRIM680.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.495
OR4F29-0.464
C6orf10-0.318
KLRB1-0.304
RSPO1-0.287
MTRNR2L10-0.274
PTGDR2-0.268
FZD10-0.264
FMO3-0.262
KLRF1-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SUPT3H mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of SUPT3H mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SUPT3H protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SUPT3H mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SUPT3H gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SUPT3H mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SUPT3H mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SUPT3H mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SUPT3H mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SUPT3H mRNA"20382639|2623829
C006780bisphenol Abisphenol A affects the expression of SUPT3H mRNA21786754
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SUPT3H gene20938992
D003024ClozapineClozapine results in increased expression of SUPT3H mRNA16715494
D016572CyclosporineCyclosporine results in increased expression of SUPT3H mRNA20106945|2556210
D013759DronabinolDronabinol results in decreased expression of SUPT3H mRNA16597638
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SUPT3H mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SUPT3H mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of SUPT3H mRNA18042831
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SUPT3H mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SUPT3H mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SUPT3H gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SUPT3H mRNA23649840
D006220HaloperidolHaloperidol results in increased expression of SUPT3H mRNA16715494
C016517indole-3-carbinolindole-3-carbinol affects the expression of SUPT3H mRNA21396975
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SUPT3H mRNA27392435
C410337K 7174K 7174 results in increased expression of SUPT3H mRNA24086573
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SUPT3H gene20938992
D008727MethotrexateMethotrexate results in decreased expression of SUPT3H mRNA24449571
D000073878Palm OilPalm Oil results in decreased expression of SUPT3H mRNA18042831
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SUPT3H mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of SUPT3H mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SUPT3H mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SUPT3H mRNA22079256
C017947sodium arsenitesodium arsenite affects the expression of SUPT3H mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SUPT3H mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SUPT3H mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SUPT3H mRNA17942748
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SUPT3H mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of SUPT3H mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of SUPT3H gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003712transcription coregulator activity-IBA21873635  
GO:0003713transcription coactivator activity-IDA11564863  
GO:0004402histone acetyltransferase activitycontributes_toIDA11564863  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-NAS9787080  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-TAS9787080  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0016578histone deubiquitination-IDA18206972  
GO:0043966histone H3 acetylation-IDA11564863  
GO:0045893positive regulation of transcription, DNA-templated-NAS9787080  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA9726987  11564863  
GO:0005654nucleoplasm-IDA-  
GO:0005669transcription factor TFIID complex-IBA21873635  
GO:0030914STAGA complex-IDA11564863  
GO:0033276transcription factor TFTC complex-IDA10373431  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-4839726Chromatin organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal