Gene: CARD6

84674
CINCIN1
caspase recruitment domain family member 6
protein-coding
5p13.1
Ensembl:ENSG00000132357 MIM:609986 Vega:OTTHUMG00000094775 UniprotKB:Q9BX69
NC_000005.10
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.783e-1 (AD)  9.662e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs704034chr5:40842014 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYOF0.898
TRIM380.885
CASP40.884
MFNG0.883
CD930.882
TGFBR20.882
ADPRH0.878
TES0.874
SP1000.874
GIMAP40.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM179-0.501
MYADML2-0.492
KCNK4-0.489
SLC7A4-0.489
MARCH4-0.489
BCL11A-0.487
DLK2-0.483
NEUROD6-0.48
HAS1-0.48
ZSCAN1-0.478

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0523831,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in increased expression of CARD6 mRNA"23373633
C50489712-(3-adamantan-1-ylureido)dodecanoic acid12-(3-adamantan-1-ylureido)dodecanoic acid results in decreased expression of CARD6 mRNA19435785
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CARD6 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARD6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARD6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CARD6 mRNA21420995|2906747
C016601afimoxifeneafimoxifene results in increased expression of CARD6 mRNA23373633
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CARD6 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CARD6 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CARD6 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of CARD6 mRNA"23195993
C006632arsenic trioxide[sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA24345465
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CARD6 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CARD6 mRNA22610609
D004958EstradiolEstradiol affects the expression of CARD6 mRNA22574217
D004958EstradiolEstradiol results in decreased expression of CARD6 mRNA20106945
D004958EstradiolEstradiol results in increased expression of CARD6 mRNA23373633
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CARD6 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CARD6 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CARD6 mRNA25181051
C546611brevetoxin 2brevetoxin 2 results in increased expression of CARD6 mRNA20498034
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of CARD6 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of CARD6 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of CARD6 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of CARD6 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of CARD6 mRNA24921660
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CARD6 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CARD6 mRNA28628672
D003633Dichlorodiphenyl DichloroethyleneDichlorodiphenyl Dichloroethylene affects the expression of CARD6 mRNA24576310
D004041Dietary FatsDietary Fats results in increased expression of CARD6 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of CARD6 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CARD6 mRNA21592394
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CARD6 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CARD6 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CARD6 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CARD6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CARD6 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CARD6 mRNA23872705|2675264
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CARD6 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CARD6 mRNA"25554681
D009532NickelNickel results in decreased expression of CARD6 mRNA23195993
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of CARD6 mRNA20971185
C016340o,p'-DDT"o,p'-DDT analog results in decreased expression of CARD6 mRNA"22937105
D010269ParaquatParaquat results in decreased expression of CARD6 mRNA18836921
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CARD6 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of CARD6 mRNA19159669
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CARD6 mRNA"27188386
C005705sanguinarine[sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA24345465
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CARD6 mRNA25895662
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CARD6 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CARD6 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CARD6 mRNA19520675
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CARD6 mRNA25613284
D014212TretinoinTretinoin results in increased expression of CARD6 mRNA23830798
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CARD6 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CARD6 mRNA17569031|2897369
D014520UrethaneUrethane results in decreased expression of CARD6 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CARD6 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of CARD6 gene29154799
C025643vinclozolinvinclozolin results in increased expression of CARD6 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16418290  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0042981regulation of apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa04621NOD-like receptor signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal