Gene: ACCS

84680
ACS|PHACS
1-aminocyclopropane-1-carboxylate synthase homolog (inactive)
protein-coding
11p11.2
Ensembl:ENSG00000110455 MIM:608405 Vega:OTTHUMG00000166427 UniprotKB:Q96QU6
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
3.543e-1 (AD)  2.469e-1 (ND)   (Frontal_Cortex)
2.873e-1 (AD)  2.753e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAA400.663
TTLL30.66
TRIM450.659
QARS0.637
LY6G5B0.637
ZNF7890.636
FPGS0.631
ANKMY10.629
DNAH10.629
WDR900.625

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C7orf61-0.375
NPC1L1-0.35
MIA-0.343
EPPIN-0.333
CELSR1-0.321
CHRNA5-0.306
RAX2-0.303
NANOS2-0.301
DLEU1-0.3
ESPNL-0.285

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03214VinylglycineSmall Molecule52773-87-2ExperimentalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACCS mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ACCS mRNA21298039
D001280AtrazineAtrazine results in decreased expression of ACCS mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of ACCS mRNA26377693
C006780bisphenol Abisphenol A affects the expression of ACCS mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ACCS mRNA26079696
C584509C646 compoundC646 compound results in increased expression of ACCS mRNA26191083
C014347decitabinedecitabine affects the expression of ACCS mRNA23300844
D002945CisplatinCisplatin affects the expression of ACCS mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ACCS mRNA27392435
C492448ICG 001ICG 001 results in increased expression of ACCS mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ACCS mRNA27392435
C544151jinfukangjinfukang results in increased expression of ACCS mRNA27392435
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ACCS mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACCS mRNA"25620056
D009532NickelNickel results in decreased expression of ACCS mRNA24768652|2558310
D010416PentachlorophenolPentachlorophenol results in increased expression of ACCS mRNA23892564
C006253pirinixic acidpirinixic acid results in increased expression of ACCS mRNA23811191
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACCS mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ACCS mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of ACCS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ACCS mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ACCS mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:00168471-aminocyclopropane-1-carboxylate synthase activityNOTIDA11470512  
GO:0030170pyridoxal phosphate binding-NAS11470512  
GO:0042802identical protein binding-IPI16189514  25416956  
GO:0042803protein homodimerization activity-NAS11470512  
GO ID GO Term Qualifier Evidence PubMed
GO:0009058biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15006985Tracheobronchial adenoid cystic carcinoma: a clinicopathologic study of 14 cases. (2004 Mar)Albers EChest