Gene: PSRC1

84722
DDA3|FP3214
proline and serine rich coiled-coil 1
protein-coding
1p13.3
Ensembl:ENSG00000134222 MIM:613126 Vega:OTTHUMG00000012000 UniprotKB:Q6PGN9
NC_000001.11
PubMed
0   ANCO-SNPs
ND
4   
5.735e-1 (AD)  2.406e-1 (ND)   (Frontal_Cortex)
5.997e-1 (AD)  8.758e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF3C50.849
SMG90.847
SAP30BP0.843
KAT80.842
TRMT10.84
MARK30.834
FADS30.834
KIAA20130.831
XAB20.829
WDR590.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.583
OR4F29-0.556
SDR42E1-0.323
KLRB1-0.306
KRT73-0.288
UNC45B-0.287
MTRNR2L9-0.282
MTRNR2L6-0.281
C8orf74-0.278
IL2RB-0.276

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PSRC1 mRNA"22129739
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PSRC1 mRNA"28903501
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PSRC1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PSRC1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PSRC1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PSRC1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PSRC1 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of PSRC1 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PSRC1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of PSRC1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of PSRC1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PSRC1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PSRC1 mRNA19770486
D001379AzathioprineAzathioprine results in decreased expression of PSRC1 mRNA22623647
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PSRC1 mRNA27858113
D001554BenzeneBenzene results in decreased expression of PSRC1 mRNA15929907
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PSRC1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PSRC1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PSRC1 mRNA20106945|2163298
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PSRC1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSRC1 mRNA19770486|2261060
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSRC1 mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of PSRC1 mRNA19167446
C044887beta-methylcholinebeta-methylcholine affects the expression of PSRC1 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PSRC1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of PSRC1 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of PSRC1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PSRC1 mRNA29097150
C006780bisphenol Abisphenol A results in increased expression of PSRC1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PSRC1 mRNA15336504
D002104CadmiumCadmium results in decreased expression of PSRC1 mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PSRC1 mRNA17484886
D002737ChloropreneChloroprene results in increased expression of PSRC1 mRNA23125180
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of PSRC1 mRNA"22129739
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PSRC1 mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PSRC1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of PSRC1 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PSRC1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of PSRC1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PSRC1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PSRC1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of PSRC1 mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of PSRC1 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of PSRC1 mRNA20106945|2163298
D003561CytarabineCytarabine results in decreased expression of PSRC1 mRNA17374387
D002945CisplatinCisplatin results in decreased expression of PSRC1 mRNA27594783
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in increased expression of PSRC1 mRNA23625948
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PSRC1 mRNA21607683|2453584
D002117CalcitriolCalcitriol results in decreased expression of PSRC1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PSRC1 mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PSRC1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PSRC1 mRNA17555576
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of PSRC1 mRNA21607683
D005472FluorouracilFluorouracil results in decreased expression of PSRC1 mRNA17374387
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PSRC1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PSRC1 mRNA23649840
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PSRC1 mRNA20044591
C031927hydroquinonehydroquinone results in decreased expression of PSRC1 mRNA23416264
D006918HydroxyureaHydroxyurea results in decreased expression of PSRC1 mRNA17374387
C544151jinfukangjinfukang results in increased expression of PSRC1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PSRC1 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PSRC1 mRNA26644586
C410337K 7174K 7174 results in decreased expression of PSRC1 mRNA24086573
C045463leflunomideleflunomide results in decreased expression of PSRC1 mRNA28988120
C045463leflunomideleflunomide results in increased expression of PSRC1 mRNA19751817
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PSRC1 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PSRC1 mRNA20713471
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PSRC1 mRNA23649840
D009151Mustard GasMustard Gas results in decreased expression of PSRC1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PSRC1 mRNA"25554681
C570897NSC668394NSC668394 results in decreased expression of PSRC1 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PSRC1 mRNA20971185
C500026palbociclibpalbociclib results in decreased expression of PSRC1 mRNA22869556
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PSRC1 mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of PSRC1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of PSRC1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PSRC1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PSRC1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PSRC1 mRNA22698814
D011374ProgesteroneProgesterone results in decreased expression of PSRC1 mRNA23012394
C005556propionaldehydepropionaldehyde results in decreased expression of PSRC1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PSRC1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PSRC1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of PSRC1 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PSRC1 mRNA19167446
C016104sodium bichromatesodium bichromate affects the expression of PSRC1 mRNA22110744
D018038Sodium SeleniteSodium Selenite results in increased expression of PSRC1 mRNA18175754
D053260SootSoot results in increased expression of PSRC1 mRNA22461453
D013629TamoxifenTamoxifen affects the expression of PSRC1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PSRC1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PSRC1 mRNA21592394
D013739TestosteroneTestosterone affects the expression of PSRC1 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PSRC1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSRC1 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PSRC1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PSRC1 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PSRC1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PSRC1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of PSRC1 mRNA22378314
D014520UrethaneUrethane results in decreased expression of PSRC1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PSRC1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PSRC1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of PSRC1 mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of PSRC1 mRNA20977926|2471476

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18411309  26820536  
GO:0008017microtubule binding-ISS12427559  
GO ID GO Term Qualifier Evidence PubMed
GO:0001578microtubule bundle formation-ISS12427559  
GO:0007080mitotic metaphase plate congression-IDA18411309  
GO:0030308negative regulation of cell growth-ISS12427559  
GO:0031116positive regulation of microtubule polymerization-ISS12427559  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-ISS12427559  
GO:0045893positive regulation of transcription, DNA-templated-ISS12427559  
GO:0051301cell division-IEA-  
GO:0060236regulation of mitotic spindle organization-IDA18411309  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle polecolocalizes_withIDA18411309  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-ISS12427559  
GO:0005819spindle-ISS12427559  
GO:0005829cytosol-IDA18411309  
GO:0005876spindle microtubulecolocalizes_withIDA18411309  
GO:0015630microtubule cytoskeleton-ISS12427559  
GO:0030496midbody-ISS12427559  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20442857Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (2010 Apr 29)Suchindran SPLoS Genet
26893834Association of genetic variants with atrial fibrillation. (2016 Feb)Yamase YBiomed Rep
25469260Association of a transcription factor 21 gene polymorphism with hypertension. (2015 Jan)Fujimaki TBiomed Rep
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One