Gene: CDC42BPA

8476
MRCK|MRCKA|PK428
CDC42 binding protein kinase alpha
protein-coding
1q42.13
Ensembl:ENSG00000143776 MIM:603412 Vega:OTTHUMG00000037618 UniprotKB:Q5VT25
NC_000001.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.373e-1 (AD)  9.378e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC6B0.929
RABGAP10.919
MPHOSPH80.916
GIGYF20.908
BACE10.904
TGOLN20.904
ARHGAP210.904
DOCK90.902
KIDINS2200.901
CTCF0.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.646
OR4F5-0.635
PDZK1IP1-0.318
PRRX2-0.3
S100A14-0.284
HORMAD2-0.27
VAX2-0.27
ZNF114-0.265
GAST-0.263
LRAT-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDC42BPA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDC42BPA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDC42BPA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDC42BPA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDC42BPA mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDC42BPA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDC42BPA mRNA"27188386
D006710HomocysteineHomocysteine results in decreased expression of CDC42BPA mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDC42BPA mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CDC42BPA mRNA24449571
D001151ArsenicArsenic affects the methylation of CDC42BPA gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of CDC42BPA mRNA15761015|1912883
C015001arsenitearsenite results in increased methylation of CDC42BPA promoter23974009
D001280AtrazineAtrazine results in decreased expression of CDC42BPA mRNA25929836
D001280AtrazineAtrazine results in decreased expression of CDC42BPA mRNA22378314
D001374AzacitidineAzacitidine results in decreased expression of CDC42BPA mRNA20823114
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNA18164116
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CDC42BPA mRNA20823114
C006780bisphenol Abisphenol A affects the expression of CDC42BPA mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CDC42BPA gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of CDC42BPA mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of CDC42BPA mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDC42BPA mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDC42BPA mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CDC42BPA mRNA26272509
D002737ChloropreneChloroprene results in increased expression of CDC42BPA mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CDC42BPA mRNA18668222
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDC42BPA mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of CDC42BPA mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CDC42BPA mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDC42BPA mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CDC42BPA mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CDC42BPA mRNA20823114
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of CDC42BPA mRNA21852083
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNA18164116
D004726EndosulfanEndosulfan results in increased expression of CDC42BPA mRNA26615145
D000431EthanolEthanol results in decreased expression of CDC42BPA mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDC42BPA mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CDC42BPA mRNA23649840
D004397FonofosFonofos results in decreased methylation of CDC42BPA promoter22847954
C492448ICG 001ICG 001 results in increased expression of CDC42BPA mRNA26191083
C051890irinotecanirinotecan analog results in decreased expression of CDC42BPA mRNA18927307
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDC42BPA mRNA26378955
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of CDC42BPA mRNA20823114
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDC42BPA mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CDC42BPA mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CDC42BPA mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CDC42BPA promoter"26251327
C523799MRK 003CDC42BPA results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CDC42BPA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDC42BPA mRNA"25554681
D010278ParathionParathion results in decreased methylation of CDC42BPA promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CDC42BPA mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CDC42BPA mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CDC42BPA mRNA26794494
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDC42BPA mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CDC42BPA mRNA18301758
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDC42BPA mRNA22714537
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of CDC42BPA mRNA21852083
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA19244175
D012643SeleniumSelenium results in decreased expression of CDC42BPA mRNA19244175
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CDC42BPA mRNA26378955
C012568terbufosterbufos results in decreased methylation of CDC42BPA promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDC42BPA mRNA21354282
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDC42BPA mRNA28065790
D014520UrethaneUrethane results in increased expression of CDC42BPA mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of CDC42BPA mRNA23179753
C029297vinylidene chloridevinylidene chloride results in increased expression of CDC42BPA protein14565772
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of CDC42BPA mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of CDC42BPA mRNA19244175
D014810Vitamin EVitamin E results in increased expression of CDC42BPA mRNA19244175
C111237vorinostatvorinostat results in decreased expression of CDC42BPA mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA9092543  
GO:0004674protein serine/threonine kinase activity-IDA9092543  11340065  11399775  21457715  
GO:0005515protein binding-IPI9418861  10644344  15194684  20936779  
GO:0005524ATP binding-IDA9092543  
GO:0042802identical protein binding-IPI11283256  23414517  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IDA9092543  
GO:0016477cell migration-IMP18854160  
GO:0031032actomyosin structure organization-IMP18854160  
GO:0031532actin cytoskeleton reorganization-IDA9418861  
GO:0035556intracellular signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005911cell-cell junction-ISS-  
GO:0030027lamellipodium-ISS-  
GO:0031252cell leading edge-ISS-  
GO:0042641actomyosin-IDA18854160  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29207374Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. (2017 Dec 1)Harris SEAging (Albany NY)
21071578A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. (2011 Jan)Balasenthil SCancer Prev Res (Phila)