Gene: GPR65

8477
TDAG8|hTDAG8
G protein-coupled receptor 65
protein-coding
14q31.3
Ensembl:ENSG00000140030 MIM:604620 Vega:OTTHUMG00000028648 UniprotKB:Q8IYL9
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.567e-1 (AD)  7.836e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR10.925
DAPP10.92
MS4A4A0.913
SNX200.909
MSR10.906
CCR50.903
PTPRC0.903
SLC7A70.903
LAIR10.901
MS4A70.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.524
EXTL1-0.505
TMEM179-0.503
NEUROD6-0.493
BCL11A-0.491
BDH1-0.482
WNT7A-0.482
MYADML2-0.481
CHRNA4-0.481
LRTM2-0.48

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of GPR65 mRNA"20638727
C496492abrineabrine results in increased expression of GPR65 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of GPR65 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GPR65 gene27153756
C430898AGN 194204AGN 194204 results in decreased expression of GPR65 mRNA16339527
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GPR65 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of GPR65 mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GPR65 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GPR65 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of GPR65 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of GPR65 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of GPR65 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of GPR65 mRNA27339419
D002330CarmustineCarmustine results in increased expression of GPR65 mRNA15980968
D002351CarrageenanCarrageenan results in increased expression of GPR65 mRNA19602228
D002737ChloropreneChloroprene results in decreased expression of GPR65 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR65 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of GPR65 mRNA20105288
D002945CisplatinCisplatin results in increased expression of GPR65 mRNA27594783
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR65 mRNA20938992
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of GPR65 mRNA19602228
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GPR65 mRNA25613284
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of GPR65 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of GPR65 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GPR65 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GPR65 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GPR65 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GPR65 mRNA"25554681
D009532NickelNickel results in increased expression of GPR65 mRNA25583101
D010100OxygenOxygen deficiency results in decreased expression of GPR65 mRNA28174749
C046012pentanalpentanal results in increased expression of GPR65 mRNA26079696
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of GPR65 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of GPR65 mRNA19564919
D012822Silicon DioxideSilicon Dioxide results in decreased expression of GPR65 mRNA19073995
D018038Sodium SeleniteSodium Selenite results in increased expression of GPR65 mRNA18175754
D053260SootSoot results in increased expression of GPR65 mRNA22461453
C016766sulforafansulforafan results in decreased expression of GPR65 mRNA26833863
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GPR65 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of GPR65 mRNA23557971|2776080
D014241TrichloroethyleneTrichloroethylene results in increased methylation of GPR65 gene27618143
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GPR65 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of GPR65 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IDA15618224  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0006955immune response-TAS9655242  
GO:0007186G-protein coupled receptor signaling pathway-IDA15618224  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA15618224  
GO:0007275multicellular organism development-TAS9655242  
GO:0010447response to acidic pH-IDA15618224  
GO:0031532actin cytoskeleton reorganization-IDA15618224  
GO:0035025positive regulation of Rho protein signal transduction-IBA21873635  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IBA21873635  
GO:0051496positive regulation of stress fiber assembly-IDA15618224  
GO:0090630activation of GTPase activity-IDA15618224  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IDA15618224  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9655242  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24876173The clinical and genetic features of COPD-asthma overlap syndrome. (2014 Aug)Hardin MEur Respir J