Gene: FCRLA

84824
FCRL|FCRL1|FCRLM1|FCRLX|FCRLb|FCRLc1|FCRLc2|FCRLd|FCRLe|FCRX|FREB
Fc receptor like A
protein-coding
1q23.3
Ensembl:ENSG00000132185 MIM:606891 Vega:OTTHUMG00000034537 UniprotKB:Q7L513
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.802e-1 (AD)  4.438e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1954174chr1:161708017 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFPI20.786
C9orf1350.765
BEST30.759
ALX30.736
MROH50.73
DPPA40.728
HAS20.714
GALR10.71
FOXI20.71
CD3G0.709

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNQ4-0.553
KCNA2-0.549
SCRT1-0.543
FUT9-0.529
EXTL1-0.521
CYP46A1-0.52
FLRT2-0.518
MPPED1-0.517
NEUROD6-0.516
CDH22-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of FCRLA mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FCRLA mRNA"27291303
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of FCRLA mRNA25088246
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FCRLA mRNA21641981
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FCRLA mRNA26377693
D001554BenzeneBenzene results in decreased expression of FCRLA mRNA19162166
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FCRLA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FCRLA mRNA21569818
D004958EstradiolEstradiol results in decreased expression of FCRLA mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of FCRLA mRNA25181051
D002104CadmiumCadmium results in increased expression of FCRLA mRNA21120746
D002737ChloropreneChloroprene results in decreased expression of FCRLA mRNA23125180
D003471CuprizoneCuprizone results in increased expression of FCRLA mRNA27523638
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FCRLA mRNA23649840
D005557FormaldehydeFCRLA gene affects the susceptibility to Formaldehyde27008852
D005557FormaldehydeFormaldehyde results in increased expression of FCRLA mRNA23649840
C039281furanfuran results in increased expression of FCRLA mRNA27387713
D019833GenisteinGenistein results in increased expression of FCRLA mRNA22553218
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FCRLA mRNA25613284
D008628MercuryMercury results in decreased expression of FCRLA mRNA16823088
C005219methyl cellosolvemethyl cellosolve results in decreased expression of FCRLA mRNA21061450
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FCRLA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FCRLA mRNA"25554681|2592637
D009532NickelNickel results in increased expression of FCRLA mRNA25583101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FCRLA mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of FCRLA mRNA25729387
D010476PerfumePerfume results in increased expression of FCRLA mRNA24768652
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FCRLA mRNA21061450
D011441PropylthiouracilPropylthiouracil affects the expression of FCRLA mRNA24780913
D053260SootSoot results in decreased expression of FCRLA mRNA26551751
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FCRLA mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of FCRLA mRNA23409001
C009495titanium dioxidetitanium dioxide results in increased expression of FCRLA mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FCRLA mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FCRLA mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of FCRLA mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FCRLA gene25487561
C025643vinclozolinvinclozolin results in increased expression of FCRLA mRNA20566332
C088658zoledronic acidzoledronic acid results in increased expression of FCRLA mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0030154cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15815692  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal