Gene: ADTRP

84830
AIG1L|C6orf105|dJ413H6.1
androgen dependent TFPI regulating protein
protein-coding
6p24.1
Ensembl:ENSG00000111863 MIM:614348 Vega:OTTHUMG00000014260 UniprotKB:Q96IZ2
NC_000006.12
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.432e-1 (AD)  5.579e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RXFP10.871
TRABD2A0.857
CNIH30.855
FOXP20.843
NRG10.839
CLSTN20.836
GALNT140.835
PKD2L10.83
RASGRP10.828
CHRM20.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNG12-0.6
RAB13-0.596
RHOD-0.58
MAML2-0.575
FGF11-0.575
PRKD3-0.571
TNFRSF11B-0.57
DDR2-0.567
EPS8-0.561
PALLD-0.56

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0293704-toluidine4-toluidine results in decreased expression of ADTRP mRNA27638505
D000638AmiodaroneAmiodarone affects the expression of ADTRP mRNA19483382
D001553BenzbromaroneBenzbromarone affects the expression of ADTRP mRNA19483382
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of ADTRP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADTRP mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADTRP mRNA22316170
C006780bisphenol Abisphenol A affects the expression of ADTRP mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of ADTRP mRNA26079696
D002994ClofibrateClofibrate results in increased expression of ADTRP mRNA23811191
D002994ClofibrateClofibrate affects the expression of ADTRP mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADTRP mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADTRP mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ADTRP mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of ADTRP mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ADTRP mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ADTRP mRNA24893172
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ADTRP mRNA28085963
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ADTRP mRNA28943392
D005001EthionineEthionine affects the expression of ADTRP mRNA19483382
D005485FlutamideFlutamide results in decreased expression of ADTRP mRNA24136188|2479361
D005557FormaldehydeFormaldehyde results in increased expression of ADTRP mRNA27664576
C039281furanfuran results in increased methylation of ADTRP gene22079235
D019833GenisteinGenistein results in increased methylation of ADTRP gene28505145
D005897GlafenineGlafenine results in decreased expression of ADTRP mRNA24136188
C412815GW 4064GW 4064 results in increased expression of ADTRP mRNA26655953
D017313FenretinideFenretinide results in increased expression of ADTRP mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADTRP mRNA23086925|2479639
C008261lead acetatelead acetate results in increased expression of ADTRP mRNA22609695
D008345ManganeseManganese results in increased expression of ADTRP mRNA18284614
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of ADTRP mRNA16507785
C500085muraglitazarmuraglitazar results in increased expression of ADTRP mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADTRP mRNA"25620056
D009538NicotineNicotine results in increased expression of ADTRP mRNA23825647
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ADTRP mRNA20971185
D009853OmeprazoleOmeprazole affects the expression of ADTRP mRNA19483382
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ADTRP mRNA26705709
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of ADTRP mRNA28558994
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of ADTRP mRNA28558994
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ADTRP mRNA28558994
C076994perfluorooctane sulfonic acidPPARA protein affects the reaction [perfluorooctane sulfonic acid results in increased expression of ADTRP mRNA]28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ADTRP mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ADTRP mRNA28511854
C006253pirinixic acidpirinixic acid affects the expression of ADTRP mRNA19483382
C005556propionaldehydepropionaldehyde results in increased expression of ADTRP mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of ADTRP mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADTRP mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of ADTRP mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of ADTRP mRNA21515302
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ADTRP mRNA23806026
D012969Sodium FluorideSodium Fluoride results in increased expression of ADTRP mRNA27862939
C501413tesaglitazartesaglitazar results in increased expression of ADTRP mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADTRP mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ADTRP mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of ADTRP mRNA19483382
C057693troglitazonetroglitazone results in increased expression of ADTRP mRNA21515302
D014635Valproic AcidValproic Acid results in decreased expression of ADTRP mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of ADTRP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ADTRP mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ADTRP gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016787hydrolase activity-IMP27018888  
GO ID GO Term Qualifier Evidence PubMed
GO:0010628positive regulation of gene expression-IMP21868574  
GO:0030195negative regulation of blood coagulation-IMP21868574  
GO:0042758long-chain fatty acid catabolic process-IMP27018888  
GO:0071383cellular response to steroid hormone stimulus-IEP21868574  
GO ID GO Term Qualifier Evidence PubMed
GO:0005901caveola-IDA21868574  
GO:0009986cell surface-IDA21868574  
GO:0012505endomembrane system-IBA21873635  
GO:0016020membrane-IDA27018888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23337689Association of single nucleotide polymorphism rs6903956 on chromosome 6p24.1 with coronary artery disease and lipid levels in different ethnic groups of the Singaporean population. (2013 Jun)Tayebi NClin Biochem
28074087The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein (ADTRP) gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese. (2017)Chang XThromb J
26375920Common Variants in Promoter of ADTRP Associate with Early-Onset Coronary Artery Disease in a Southern Han Chinese Population. (2015)Huang EWPLoS One