Gene: GALR3

8484
-
galanin receptor 3
protein-coding
22q13.1
Ensembl:ENSG00000128310 MIM:603692 Vega:OTTHUMG00000150658 UniprotKB:O60755
NC_000022.11
PubMed
0   ANCO-SNPs
OD|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.833e-1 (AD)  3.035e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C4orf480.497
ZNF7710.466
ANKRD90.464
TMEM1600.458
MESP10.452
TGFBR3L0.45
PRR70.439
FEM1A0.438
ENDOG0.429
CTU10.428

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CC2D2B-0.315
LRRC70-0.296
IL18RAP-0.287
P2RX1-0.283
TRIM6-0.283
XIRP2-0.276
VNN2-0.274
GJA5-0.273
MTFR2-0.271
FFAR2-0.27

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GALR3 mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of GALR3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GALR3 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of GALR3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GALR3 mRNA16483693
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of GALR3 mRNA26945725
D004958EstradiolEstradiol results in increased expression of GALR3 mRNA26945725
C006780bisphenol Abisphenol A results in decreased expression of GALR3 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of GALR3 mRNA17585979
D007854LeadLead results in decreased expression of GALR3 mRNA19921347
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GALR3 mRNA21385734
D010936Plant ExtractsPlant Extracts results in decreased expression of GALR3 mRNA23557933
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of GALR3 mRNA26945725
C012526quercitrinquercitrin results in increased expression of GALR3 mRNA25193878
D018038Sodium SeleniteSodium Selenite results in increased expression of GALR3 mRNA18175754
D014635Valproic AcidValproic Acid results in increased methylation of GALR3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GALR3 gene25560391
D014810Vitamin EVitamin E results in increased expression of GALR3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004966galanin receptor activity-IBA21873635  
GO:0004966galanin receptor activity-IDA9832121  24517231  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO:0017046peptide hormone binding-IDA24517231  
GO:0017046peptide hormone binding-IPI9832121  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IDA9832121  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007194negative regulation of adenylate cyclase activity-IEA-  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-TAS9722565  
GO:0007268chemical synaptic transmission-TAS9722565  
GO:0007611learning or memory-TAS9722565  
GO:0007631feeding behavior-TAS9722565  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA24517231  
GO:0090663galanin-activated signaling pathway-IDA9832121  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-TAS9722565  
GO:0097730non-motile cilium-IEA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21955024Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala. (2012 Jul)Bajo MAddict Biol
17083333Alcoholism is associated with GALR3 but not two other galanin receptor genes. (2007 Jul)Belfer IGenes Brain Behav
21969124Galanin negatively modulates opiate withdrawal via galanin receptor 1. (2012 Apr)Holmes FEPsychopharmacology (Berl)