Gene: ORAI1

84876
CRACM1|IMD9|ORAT1|TAM2|TMEM142A
ORAI calcium release-activated calcium modulator 1
protein-coding
12q24.31
Ensembl:ENSG00000276045 MIM:610277 UniprotKB:Q96D31
NG_007500.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.243e-1 (AD)  5.182e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLIC10.85
EMP30.848
TAGLN20.842
VASP0.841
TGFB10.841
MYL12A0.84
SIPA10.836
DRAM10.833
STAT5A0.827
LTBR0.821

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB2-0.556
SLC7A4-0.54
MARCH4-0.533
GRIN2B-0.526
PPEF1-0.523
GPR61-0.522
ST6GALNAC5-0.522
NDST3-0.522
CHRNB2-0.522
CDH8-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5837162,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide"2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]"26033013
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]25870318
C5387582-aminoethyl diphenylborinate2-aminoethyl diphenylborinate inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]26033013
D000082AcetaminophenAcetaminophen results in increased expression of ORAI1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ORAI1 mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ORAI1 mRNA21839799
D004958EstradiolEstradiol affects the expression of ORAI1 mRNA22574217
C006780bisphenol Abisphenol A results in decreased methylation of ORAI1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ORAI1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ORAI1 mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ORAI1 mRNA24982889
D002118CalciumORAI1 protein results in increased uptake of Calcium24990931
D002118Calcium[Calcium affects the activity of and affects the localization of STIM1 protein] which affects the activity of ORAI1 protein23212906
D002118CalciumCalcium affects the reaction [STIM1 protein binds to ORAI1 protein]23212906
D002220CarbamazepineCarbamazepine affects the expression of ORAI1 mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ORAI1 gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of ORAI1 mRNA19549813
C113861corosolic acidcorosolic acid inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]26033013
D003471CuprizoneCuprizone results in increased expression of ORAI1 mRNA27523638
D003703DemecolcineDemecolcine results in decreased expression of ORAI1 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ORAI1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ORAI1 mRNA21266533
D004147DioxinsDioxins affects the expression of ORAI1 mRNA20463971
D000431EthanolEthanol results in increased expression of ORAI1 mRNA22119170
D000431EthanolEthanol results in increased expression of ORAI1 protein22119170
D000431Ethanol"2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]"26033013
D000431Ethanol2-aminoethyl diphenylborinate inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]26033013
D000431Ethanolcorosolic acid inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]26033013
D000431EthanolEthanol results in increased expression of ORAI1 mRNA26033013
D000431EthanolEthanol results in increased expression of ORAI1 protein26033013
D000431EthanolLanthanoid Series Elements inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]26033013
D000431EthanolORAI1 protein affects the reaction [Ethanol results in increased cleavage of CASP3 protein]26033013
D005230Fatty Acids, Nonesterified"Fatty Acids, Nonesterified promotes the reaction [STIM1 protein binds to ORAI1 protein]"23527285
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ORAI1 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of ORAI1 mRNA19167457
D006533HeptachlorHeptachlor results in decreased expression of ORAI1 mRNA23153324
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ORAI1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ORAI1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ORAI1 mRNA28628672
D028581Lanthanoid Series ElementsLanthanoid Series Elements inhibits the reaction [Ethanol results in increased expression of ORAI1 protein]26033013
D007854Lead[ORAI1 protein binds to STIM1 protein] which results in increased transport of and affects the susceptibility to Lead19429662
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of ORAI1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ORAI1 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ORAI1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ORAI1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of ORAI1 mRNA19167457
D010416PentachlorophenolPentachlorophenol results in increased expression of ORAI1 mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of ORAI1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of ORAI1 mRNA23557933
C058229polydatinORAI1 protein affects the susceptibility to polydatin22959927
D011374ProgesteroneProgesterone results in decreased expression of ORAI1 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of ORAI1 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ORAI1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ORAI1 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ORAI1 mRNA25613284
D019284ThapsigarginORAI1 protein results in increased susceptibility to Thapsigargin24990931
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ORAI1 mRNA19969065
C073339usnic acid2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]25870318
C073339usnic acidusnic acid results in increased expression of ORAI1 protein25870318
C073339usnic acidusnic acid results in increased expression of ORAI1 protein25870318
D014635Valproic AcidValproic Acid results in increased methylation of ORAI1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ORAI1 gene25560391
D014750VincristineVincristine results in decreased expression of ORAI1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17360584  17905723  19249086  19706554  19887627  20418871  
20887894  21408196  21427704  21876174  22451904  22464749  
22586105  23307288  24954132  24996186  27185316  28219928  
GO:0005516calmodulin binding-IEA-  
GO:0015279store-operated calcium channel activity-IBA21873635  
GO:0015279store-operated calcium channel activity-IDA16645049  16733527  16766533  16807233  23307288  28219928  
GO:0042802identical protein binding-IPI18757751  19249086  20018736  20194792  24996186  
GO ID GO Term Qualifier Evidence PubMed
GO:0002115store-operated calcium entry-IBA21873635  
GO:0002115store-operated calcium entry-IDA28219928  
GO:0002250adaptive immune response-IEA-  
GO:0051924regulation of calcium ion transport-IMP16921383  
GO:0051928positive regulation of calcium ion transport-IDA16645049  16733527  16766533  16807233  
GO:0061180mammary gland epithelium development-IEA-  
GO:0070509calcium ion import-IEA-  
GO:0070588calcium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA27185316  
GO:0005887integral component of plasma membrane-IDA16645049  28219928  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0016323basolateral plasma membrane-IEA-  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-139853Elevation of cytosolic Ca2+ levelsIEA
R-HSA-168256Immune SystemIEA
R-HSA-397014Muscle contractionIEA
R-HSA-418346Platelet homeostasisIEA
R-HSA-418360Platelet calcium homeostasisIEA
R-HSA-5576891Cardiac conductionIEA
R-HSA-5578775Ion homeostasisIEA
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersIEA
R-HSA-983705Signaling by the B Cell Receptor (BCR)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25623308[Polarization of neutrophils from patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease overlap syndrome]. (2014 Dec 30)Deng FZhonghua Yi Xue Za Zhi
26075746Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle. (2015)Wylam MEPLoS One