Gene: AIFM2

84883
AMID|PRG3
apoptosis inducing factor, mitochondria associated 2
protein-coding
10q22.1
Ensembl:ENSG00000042286 MIM:605159 Vega:OTTHUMG00000018398 UniprotKB:Q9BRQ8
NC_000010.11
PubMed
0   ANCO-SNPs
ND
1   
9.653e-1 (AD)  4.615e-1 (ND)   (Frontal_Cortex)
9.586e-2 (AD)  2.937e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DVL20.788
NELFA0.757
PUS10.75
COG70.748
FADS30.748
CDAN10.744
FANCG0.744
MAATS10.742
AKT20.741
RBCK10.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.461
OR4F29-0.433
ADAMTS5-0.242
KLRC2-0.227
FCRL4-0.226
SCARA5-0.221
CTNNA3-0.216
RD3L-0.212
CD244-0.212
CETP-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of AIFM2 mRNA"26377693
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of AIFM2 mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of AIFM2 mRNA"28903501
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of AIFM2 mRNA"20406850
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AIFM2 mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AIFM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AIFM2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AIFM2 mRNA25704631|2669055
D000452AldrinAldrin results in decreased expression of AIFM2 mRNA18579281
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of AIFM2 mRNA23656968
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AIFM2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AIFM2 mRNA21632981|2623829
C006780bisphenol Abisphenol A affects the methylation of AIFM2 promoter27415467
C006780bisphenol Abisphenol A results in increased expression of AIFM2 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of AIFM2 mRNA20977926
D002084Butylated Hydroxytoluene"Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of AIFM2 protein]"14987999
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of AIFM2 protein]14987999
D002104CadmiumCadmium results in decreased expression of AIFM2 mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AIFM2 mRNA25596134
C034939cadmium sulfidecadmium sulfide results in increased expression of AIFM2 mRNA27866839
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of AIFM2 mRNA25596134
D004002Clodronic AcidClodronic Acid affects the expression of AIFM2 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of AIFM2 mRNA19320972
D003042CocaineCocaine affects the expression of AIFM2 mRNA15681117
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AIFM2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of AIFM2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of AIFM2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of AIFM2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of AIFM2 mRNA25596134
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of AIFM2 mRNA24317228
D003907DexamethasoneDexamethasone results in increased expression of AIFM2 mRNA25047013
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AIFM2 mRNA24848799
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AIFM2 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of AIFM2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AIFM2 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of AIFM2 protein27392435
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of AIFM2 mRNA]27392435
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of AIFM2 protein]27392435
D002945CisplatinCisplatin results in decreased expression of AIFM2 mRNA25596134
D002945CisplatinCisplatin results in increased expression of AIFM2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of AIFM2 protein27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of AIFM2 mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of AIFM2 protein]27392435
D004026DieldrinDieldrin affects the expression of AIFM2 mRNA22546817
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of AIFM2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in decreased expression of AIFM2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of AIFM2 mRNA19467301
D004317DoxorubicinDoxorubicin results in decreased expression of AIFM2 mRNA19915844
D004726EndosulfanEndosulfan results in increased expression of AIFM2 mRNA26722802
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AIFM2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIFM2 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of AIFM2 mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of AIFM2 mRNA25455459
D011345FenofibrateFenofibrate results in increased expression of AIFM2 mRNA25596134
D011345FenofibrateFenofibrate results in increased expression of AIFM2 mRNA25596134
C069837fullerene C60fullerene C60 results in increased expression of AIFM2 mRNA19167457
C026226ganglioside, GD3"Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of AIFM2 protein]"14987999
C026226ganglioside, GD3"ganglioside, GD3 results in increased secretion of AIFM2 protein"14987999
D017313FenretinideFenretinide results in decreased expression of AIFM2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AIFM2 mRNA20044591
D006861Hydrogen PeroxideButylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of AIFM2 protein]14987999
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of AIFM2 protein14987999
D007052IbuprofenIbuprofen results in increased expression of AIFM2 mRNA25596134
D007052IbuprofenIbuprofen results in increased expression of AIFM2 mRNA25596134
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AIFM2 mRNA24848799
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AIFM2 mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of AIFM2 protein27392435
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of AIFM2 mRNA]27392435
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of AIFM2 protein]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of AIFM2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of AIFM2 protein]27392435
C544151jinfukangjinfukang results in increased expression of AIFM2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of AIFM2 protein27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AIFM2 mRNA23430699
D008687MetforminMetformin results in decreased expression of AIFM2 mRNA25596134
D008727MethotrexateMethotrexate affects the expression of AIFM2 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AIFM2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AIFM2 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of AIFM2 mRNA20886546
C523799MRK 003AIFM2 results in increased susceptibility to MRK 00319903844
C022838nickel chloridenickel chloride affects the expression of AIFM2 mRNA22546817
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AIFM2 mRNA20971185
D010100OxygenOxygen deficiency results in decreased expression of AIFM2 mRNA25596134
D000073878Palm OilPalm Oil results in decreased expression of AIFM2 mRNA18042831
D010634PhenobarbitalPhenobarbital results in increased expression of AIFM2 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AIFM2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of AIFM2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of AIFM2 mRNA18301758|2081375
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AIFM2 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of AIFM2 mRNA24780913
C089730rosiglitazonerosiglitazone results in increased expression of AIFM2 mRNA24848799
C089730rosiglitazonerosiglitazone results in increased expression of AIFM2 mRNA25596134
D012402RotenoneRotenone results in decreased expression of AIFM2 mRNA19013527
C009277sodium arsenatesodium arsenate results in increased expression of AIFM2 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of AIFM2 mRNA21281968|2549360
D013467SulindacSulindac results in increased expression of AIFM2 mRNA11906190
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AIFM2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AIFM2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AIFM2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AIFM2 mRNA19770486
C009495titanium dioxidetitanium dioxide results in decreased expression of AIFM2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of AIFM2 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AIFM2 mRNA27255386
C011559tributyltintributyltin results in increased expression of AIFM2 mRNA24848799
D014241TrichloroethyleneTrichloroethylene results in increased expression of AIFM2 mRNA25549359
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AIFM2 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of AIFM2 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of AIFM2 mRNA25596134
D014520UrethaneUrethane results in decreased expression of AIFM2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of AIFM2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AIFM2 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of AIFM2 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA15958387  
GO:0004174electron-transferring-flavoprotein dehydrogenase activity-IBA21873635  
GO:0004174electron-transferring-flavoprotein dehydrogenase activity-IDA15958387  
GO:0050660flavin adenine dinucleotide binding-IBA21873635  
GO:0050660flavin adenine dinucleotide binding-IDA15958387  
GO ID GO Term Qualifier Evidence PubMed
GO:0008637apoptotic mitochondrial changes-IBA21873635  
GO:0008637apoptotic mitochondrial changes-IDA11980907  
GO:0022904respiratory electron transport chain-IEA-  
GO:0042981regulation of apoptotic process-TAS-  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043065positive regulation of apoptotic process-IDA11980907  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA12135761  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA11980907  
GO:0005741mitochondrial outer membrane-IDA11980907  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005811lipid droplet-IDA14741744  
GO:0005829cytosol-IDA11980907  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29654602A Genome-Wide Association Study identifies new genes potentially associated with eyelid sagging. (2018 Apr 13)Laville VExp Dermatol