Gene: ADO

84890
C10orf22
2-aminoethanethiol dioxygenase
protein-coding
10q21.3
Ensembl:ENSG00000181915 MIM:611392 Vega:OTTHUMG00000018306 UniprotKB:Q96SZ5
NC_000010.11
PubMed
0   ANCO-SNPs
OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.149e-1 (AD)  7.398e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20684110chr10:64565750ADO1.400e-12Smoking27651444
cg01005506chr10:64565768ADO6.200e-9Smoking27651444
cg12474798chr10:64565772ADO5.600e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STAM0.949
SLC25A460.948
FEM1B0.947
CUL30.947
CUL20.946
AFTPH0.945
GRSF10.945
PPP2R5E0.945
SLU70.944
SRPK20.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.578
OR4F29-0.533
CSAG1-0.414
SLC2A4-0.368
MAGEA12-0.368
RHOD-0.361
MYL3-0.354
HEYL-0.348
RUNX3-0.346
S100A12-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADO gene27153756
D001280AtrazineAtrazine results in decreased expression of ADO mRNA22378314
C006780bisphenol Abisphenol A results in increased methylation of ADO gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ADO mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ADO promoter22457795
D019327Copper SulfateCopper Sulfate results in decreased expression of ADO mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of ADO mRNA26577399
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ADO mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADO mRNA21266533
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ADO protein23301498
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of ADO promoter27415467
D005557FormaldehydeFormaldehyde results in increased expression of ADO mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ADO mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ADO mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ADO mRNA28628672
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ADO mRNA25613284
D008731MethoxychlorMethoxychlor results in increased expression of ADO mRNA21276474
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADO mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of ADO mRNA19167457
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADO mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ADO mRNA25613284
D014520UrethaneUrethane results in decreased expression of ADO mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ADO mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ADO gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0047800cysteamine dioxygenase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000098sulfur amino acid catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00430Taurine and hypotaurine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1614558Degradation of cysteine and homocysteineTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27103389Prognostic assessment in COPD without lung function: the B-AE-D indices. (2016 Jun)Boeck LEur Respir J
1676713Much ado about gastrin. (1991 Jun)McQuaid KRJ Clin Gastroenterol
23537163Frequency of multi-dimensional COPD indices and relation with disease activity markers. (2013 Aug)Garcia-Rio FCOPD
27042875Cigarette Smoking, BPDE-DNA Adducts, and Aberrant Promoter Methylations of Tumor Suppressor Genes (TSGs) in NSCLC from Chinese Population. (2016)Jin YCancer Invest
10639897Hyperhomocysteinemia: an additional cardiovascular risk factor. (1999 Dec)Fanapour PCWMJ
24212058Presynaptic adenosine A(1) receptors modulate excitatory transmission in the rat basolateral amygdala. (2014 Feb)Rau ARNeuropharmacology