Gene: LINGO1

84894
LERN1|LRRN6A|UNQ201
leucine rich repeat and Ig domain containing 1
protein-coding
15q24.3
Ensembl:ENSG00000169783 MIM:609791 Vega:OTTHUMG00000172629 UniprotKB:Q96FE5
NC_000015.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.603e-1 (AD)  9.781e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNB10.967
RAB150.965
SYNGR10.961
ATCAY0.959
SLC8A20.959
STX1B0.957
SYT70.957
STX1A0.956
TOLLIP0.955
PGBD50.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.543
OR4F5-0.536
WWTR1-0.524
YES1-0.52
HEY2-0.509
SNHG18-0.504
RBPMS-0.502
CLEC2B-0.501
CNN2-0.496
RAI14-0.49

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of LINGO1 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LINGO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LINGO1 mRNA"27188386
D000447AldehydesAldehydes results in increased expression of LINGO1 mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of LINGO1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to LINGO1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LINGO1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of LINGO1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of LINGO1 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of LINGO1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of LINGO1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of LINGO1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LINGO1 gene20938992
D002945CisplatinCisplatin results in increased expression of LINGO1 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of LINGO1 mRNA26485663
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LINGO1 gene20938992
C039281furanfuran results in increased methylation of LINGO1 gene22079235
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of LINGO1 mRNA22634610
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LINGO1 mRNA26752646
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LINGO1 mRNA22185406
D008070LipopolysaccharidesQuercetin promotes the reaction [Lipopolysaccharides results in increased expression of LINGO1 mRNA]22185406
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LINGO1 gene20938992
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of LINGO1 mRNA24888373
C046012pentanalpentanal results in increased expression of LINGO1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LINGO1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of LINGO1 mRNA26272509
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of LINGO1 mRNA24888373
C005556propionaldehydepropionaldehyde results in increased expression of LINGO1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of LINGO1 mRNA24780913
D011794QuercetinQuercetin promotes the reaction [Lipopolysaccharides results in increased expression of LINGO1 mRNA]22185406
D011794QuercetinQuercetin results in increased expression of LINGO1 mRNA22185406
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LINGO1 mRNA25895662
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of LINGO1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LINGO1 mRNA22808131
D014212TretinoinTretinoin results in decreased expression of LINGO1 mRNA21934132|2372400
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of LINGO1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of LINGO1 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of LINGO1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of LINGO1 gene29154799
C025643vinclozolinvinclozolin affects the expression of LINGO1 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005154epidermal growth factor receptor binding-IBA21873635  
GO:0005515protein binding-IPI17726113  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0050771negative regulation of axonogenesis-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-193634Axonal growth inhibition (RHOA activation)TAS
R-HSA-193697p75NTR regulates axonogenesisTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-73887Death Receptor SignallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28990359Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors. (2017 Dec)Polimanti RAm J Med Genet B Neuropsychiatr Genet