Gene: TMTC4

84899
-
transmembrane and tetratricopeptide repeat containing 4
protein-coding
13q32.3
Ensembl:ENSG00000125247 Vega:OTTHUMG00000017289 UniprotKB:Q5T4D3
NG_053145.1
SNP Mapped
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.544e-1 (AD)  8.178e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9554711chr13:100624630 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABHD17B0.841
EDIL30.833
NT5DC10.826
KCNH80.82
PDE1C0.818
TF0.817
PSEN10.811
PLEKHH10.808
PRRG10.805
STRN0.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.407
OR4F29-0.397
WTIP-0.358
EPPIN-0.335
FOXJ1-0.304
EVC2-0.301
MMP23B-0.3
DIO3-0.295
MTRNR2L8-0.294
CXorf67-0.292

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of TMTC4 mRNA"22698814|2890350
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of TMTC4 mRNA]"19414516
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of TMTC4 mRNA]"19414516
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TMTC4 mRNA21420995|2906747
D020106AcrylamideAcrylamide results in decreased expression of TMTC4 mRNA28959563
D000242Cyclic AMP"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of TMTC4 mRNA]"19414516
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TMTC4 gene27153756
D001280AtrazineAtrazine results in decreased expression of TMTC4 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of TMTC4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMTC4 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TMTC4 mRNA19770486
C044887beta-methylcholinebeta-methylcholine affects the expression of TMTC4 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of TMTC4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased methylation of TMTC4 promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of TMTC4 promoter27312807
C006780bisphenol Abisphenol A affects the expression of TMTC4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of TMTC4 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TMTC4 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of TMTC4 mRNA26079696
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of TMTC4 mRNA26272509
C018021cobaltous chloridecobaltous chloride results in decreased expression of TMTC4 mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of TMTC4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of TMTC4 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of TMTC4 mRNA24650576
D003471CuprizoneCuprizone results in decreased expression of TMTC4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TMTC4 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of TMTC4 mRNA16597638
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TMTC4 mRNA28628672
D002945CisplatinCisplatin results in increased expression of TMTC4 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of TMTC4 mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TMTC4 mRNA24535843
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TMTC4 mRNA22129741
C118739entinostatentinostat results in decreased expression of TMTC4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C024565ethylene dichlorideethylene dichloride results in decreased expression of TMTC4 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TMTC4 mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of TMTC4 mRNA23649840
C039281furanfuran results in decreased expression of TMTC4 mRNA26194646
D017313FenretinideFenretinide results in decreased expression of TMTC4 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of TMTC4 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TMTC4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TMTC4 mRNA28628672
C544151jinfukangjinfukang results in increased expression of TMTC4 mRNA27392435
D007649KetamineKetamine results in decreased expression of TMTC4 mRNA20080153
C008261lead acetatelead acetate results in increased expression of TMTC4 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TMTC4 mRNA"24972896
C042720mercuric bromidemercuric bromide results in decreased expression of TMTC4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TMTC4 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TMTC4 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TMTC4 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TMTC4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TMTC4 mRNA"25554681|2562005
C025256nonylphenolnonylphenol results in increased expression of TMTC4 mRNA22982499
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of TMTC4 mRNA20971185
D000073878Palm OilPalm Oil results in increased expression of TMTC4 mRNA18042831
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of TMTC4 mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of TMTC4 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of TMTC4 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TMTC4 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of TMTC4 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of TMTC4 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of TMTC4 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMTC4 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TMTC4 mRNA28065790
D014212TretinoinTretinoin results in increased expression of TMTC4 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TMTC4 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TMTC4 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TMTC4 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of TMTC4 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMTC4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TMTC4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMTC4 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of TMTC4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TMTC4 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TMTC4 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of TMTC4 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal