Gene: FAM136A

84908
-
family with sequence similarity 136 member A
protein-coding
2p13.3
Ensembl:ENSG00000035141 MIM:616275 Vega:OTTHUMG00000129668 UniprotKB:Q96C01
NG_051290.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.983e-1 (AD)  1.303e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRPS350.92
CISD10.919
VDAC30.919
CCDC28A0.917
TRAPPC30.916
CNRIP10.915
EIF1B0.914
RAN0.913
ASNSD10.912
MKKS0.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.633
OR4F29-0.587
KLRB1-0.362
MAGEA12-0.341
IL18RAP-0.341
FZD10-0.329
ZBTB20-0.326
TFPI2-0.325
CSAG1-0.322
KCNJ15-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FAM136A mRNA28329830
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM136A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM136A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FAM136A mRNA25704631
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FAM136A gene27153756
C044887beta-methylcholinebeta-methylcholine affects the expression of FAM136A mRNA21179406
C006780bisphenol Abisphenol A affects the expression of FAM136A mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FAM136A mRNA25181051
C018021cobaltous chloridecobaltous chloride results in decreased expression of FAM136A mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of FAM136A mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of FAM136A mRNA25562108
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of FAM136A mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FAM136A mRNA21266533
D004237DiuronDiuron results in increased expression of FAM136A mRNA21551480
D018120FinasterideFinasteride results in increased expression of FAM136A mRNA24136188
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of FAM136A mRNA28329830
D005485FlutamideFlutamide results in increased expression of FAM136A mRNA24136188
C492448ICG 001ICG 001 results in increased expression of FAM136A mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM136A mRNA25613284
D007649KetamineKetamine results in decreased expression of FAM136A mRNA20080153
C051752nefazodonenefazodone results in increased expression of FAM136A mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM136A mRNA25729387
C045950propiconazolepropiconazole results in increased expression of FAM136A mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of FAM136A mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM136A mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM136A mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM136A mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of FAM136A protein20109541
D013853ThioacetamideThioacetamide results in increased expression of FAM136A mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FAM136A mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FAM136A mRNA"26179874
D014520UrethaneUrethane results in decreased expression of FAM136A mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of FAM136A mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FAM136A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FAM136A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FAM136A mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28559012Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. (2017 Jun)Wang SJOral Oncol