Gene: MAP4K3

8491
GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1
mitogen-activated protein kinase kinase kinase kinase 3
protein-coding
2p22.1
Ensembl:ENSG00000011566 MIM:604921 Vega:OTTHUMG00000102127 UniprotKB:Q8IVH8
NG_028007.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.488e-1 (AD)  5.273e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KPNA30.951
MARCH60.947
FAM8A10.944
ZRANB20.942
CD470.942
ZDHHC170.941
DCUN1D40.938
GTF2A10.938
THUMPD10.936
CUL4B0.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.622
OR4F29-0.574
CSAG1-0.352
MTRNR2L10-0.313
MTRNR2L9-0.305
MTRNR2L6-0.294
KLRB1-0.263
NKX6-1-0.259
MTRNR2L2-0.258
TTLL10-0.254

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MAP4K3 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MAP4K3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MAP4K3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of MAP4K3 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP4K3 mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MAP4K3 mRNA"19150397
D004958EstradiolEstradiol promotes the reaction [ESR1 protein binds to MAP4K3 promoter]23019147
D004958EstradiolEstradiol results in increased expression of MAP4K3 mRNA23019147
C006780bisphenol Abisphenol A promotes the reaction [ESR1 protein binds to MAP4K3 promoter]23019147
C006780bisphenol Abisphenol A results in decreased expression of MAP4K3 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MAP4K3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAP4K3 gene28505145
D000069286BortezomibBortezomib results in increased expression of MAP4K3 mRNA20977926
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MAP4K3 mRNA23650126
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of MAP4K3 mRNA16197558
C018021cobaltous chloridecobaltous chloride results in increased expression of MAP4K3 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of MAP4K3 mRNA15467011
D016572CyclosporineCyclosporine results in decreased expression of MAP4K3 mRNA25562108
D004041Dietary FatsDietary Fats results in increased expression of MAP4K3 mRNA18042831
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAP4K3 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of MAP4K3 mRNA20655997
D005839GentamicinsGentamicins results in increased expression of MAP4K3 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of MAP4K3 mRNA24136188
C051890irinotecanirinotecan analog results in decreased expression of MAP4K3 mRNA18927307
C544151jinfukangjinfukang results in decreased expression of MAP4K3 mRNA27392435
C410337K 7174K 7174 results in increased expression of MAP4K3 mRNA24086573
C013598methoxyacetic acidmethoxyacetic acid affects the expression of MAP4K3 mRNA20864626
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP4K3 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of MAP4K3 mRNA18042831
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of MAP4K3 mRNA17616710
D010936Plant ExtractsPlant Extracts results in increased expression of MAP4K3 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAP4K3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MAP4K3 mRNA22079256
D053260SootSoot affects the methylation of MAP4K3 promoter25395096
D013467SulindacSulindac results in increased expression of MAP4K3 mRNA11906190
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP4K3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP4K3 mRNA22298810
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MAP4K3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MAP4K3 mRNA25729387
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MAP4K3 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of MAP4K3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MAP4K3 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS9275185  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA9275185  
GO:0005515protein binding-IPI17474147  20936779  21983831  
GO:0005524ATP binding-IDA9275185  
GO:0008349MAP kinase kinase kinase kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000185activation of MAPKKK activity-IEA-  
GO:0006468protein phosphorylation-IDA9275185  
GO:0007254JNK cascade-TAS9275185  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0009411response to UV-IDA9275185  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0034612response to tumor necrosis factor-IDA9275185  
GO:0035556intracellular signal transduction-IDA9275185  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27203390GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. (2016 Jul 5)Hsu CPOncotarget