Gene: SLC35B4

84912
YEA|YEA4
solute carrier family 35 member B4
protein-coding
7q33
Ensembl:ENSG00000205060 MIM:610923 Vega:OTTHUMG00000155321 UniprotKB:Q969S0
NC_000007.14
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.757e-1 (AD)  6.524e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATRN0.968
MYCBP20.967
GPRASP10.966
RNMT0.963
DMXL20.962
GSK3B0.96
WDR120.96
KLHL420.959
TMEM178B0.958
G3BP20.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.508
HEY2-0.502
MYL3-0.486
RAB13-0.478
ROM1-0.473
OR4F5-0.461
CNN2-0.45
RAI14-0.448
YES1-0.444
TGIF1-0.442

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of SLC35B4 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of SLC35B4 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC35B4 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC35B4 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of SLC35B4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC35B4 gene28505145
D002065BuspironeBuspirone results in decreased expression of SLC35B4 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of SLC35B4 mRNA26079696
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC35B4 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SLC35B4 mRNA20106945|2556210
D002945CisplatinCisplatin results in decreased expression of SLC35B4 mRNA27594783
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of SLC35B4 mRNA19118595
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC35B4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC35B4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC35B4 mRNA17942748
C082360fipronilfipronil results in decreased expression of SLC35B4 mRNA23962444
D005485FlutamideFlutamide results in increased expression of SLC35B4 mRNA24136188
D005897GlafenineGlafenine results in increased expression of SLC35B4 mRNA24136188
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC35B4 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SLC35B4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC35B4 mRNA"25554681
C012655nimesulidenimesulide results in increased expression of SLC35B4 mRNA24136188
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SLC35B4 mRNA23427857
C006253pirinixic acidpirinixic acid results in increased expression of SLC35B4 mRNA18301758
D012999SomanSoman results in decreased expression of SLC35B4 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of SLC35B4 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC35B4 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC35B4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC35B4 mRNA20159946
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC35B4 mRNA17942748
D014520UrethaneUrethane results in decreased expression of SLC35B4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SLC35B4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC35B4 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC35B4 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC35B4 gene25560391
D015215ZidovudineZidovudine results in increased expression of SLC35B4 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005457GDP-fucose transmembrane transporter activity-IBA21873635  
GO:0005462UDP-N-acetylglucosamine transmembrane transporter activity-IBA21873635  
GO:0005462UDP-N-acetylglucosamine transmembrane transporter activity-IDA15911612  
GO:0005462UDP-N-acetylglucosamine transmembrane transporter activity-TAS-  
GO:0005464UDP-xylose transmembrane transporter activity-IBA21873635  
GO:0005464UDP-xylose transmembrane transporter activity-IDA15911612  
GO:0005464UDP-xylose transmembrane transporter activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:00469643'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006111regulation of gluconeogenesis-IEA-  
GO:0008643carbohydrate transport-IEA-  
GO:0015783GDP-fucose transmembrane transport-IBA21873635  
GO:0015790UDP-xylose transmembrane transport-IBA21873635  
GO:0015790UDP-xylose transmembrane transport-IDA15911612  
GO:1990569UDP-N-acetylglucosamine transmembrane transport-IDA15911612  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005783endoplasmic reticulum-IDA21918738  
GO:0005794Golgi apparatus-IDA15911612  
GO:0030173integral component of Golgi membrane-IBA21873635  
GO:0030176integral component of endoplasmic reticulum membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425397Transport of vitamins, nucleosides, and related moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-727802Transport of nucleotide sugarsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (2011 May)Kendler KSAlcohol Clin Exp Res