Gene: PPM1D

8493
IDDGIP|PP2C-DELTA|WIP1
protein phosphatase, Mg2+/Mn2+ dependent 1D
protein-coding
17q23.2
Ensembl:ENSG00000170836 MIM:605100 Vega:OTTHUMG00000180052 UniprotKB:O15297
NG_023265.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  9.935e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF4100.845
NFKB10.834
PPP1R15B0.831
DHX150.829
NUP980.827
INTS60.82
BIRC20.812
XRN20.808
SMNDC10.805
PCF110.804

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.403
OR4F29-0.376
HES5-0.344
NEU4-0.264
HPDL-0.26
REN-0.228
BTBD17-0.227
NXNL1-0.227
C12orf54-0.218
PTGDR2-0.211

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of PPM1D mRNA25596134
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PPM1D mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PPM1D mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of PPM1D mRNA17562736
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of PPM1D mRNA25596134
C016601afimoxifeneafimoxifene results in decreased expression of PPM1D mRNA16514628
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PPM1D protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PPM1D mRNA21632981|2164198
D016604Aflatoxin B1TP53 protein affects the reaction [Aflatoxin B1 results in increased expression of PPM1D mRNA]22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PPM1D mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PPM1D mRNA24449571
D001151ArsenicArsenic affects the methylation of PPM1D gene25304211
C006632arsenic trioxidearsenic trioxide affects the activity of PPM1D18482988
C006632arsenic trioxidearsenic trioxide results in decreased expression of PPM1D protein21175813
C006632arsenic trioxideMIR29A protein affects the reaction [arsenic trioxide results in decreased expression of PPM1D protein]21175813
C006632arsenic trioxidePPM1D mutant form promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of CHEK2 protein]18482988
C006632arsenic trioxidePPM1D mutant form promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]18482988
C006632arsenic trioxidearsenic trioxide inhibits the reaction [PPM1D protein results in decreased phosphorylation of CHEK2 protein]18482988
C006632arsenic trioxidearsenic trioxide inhibits the reaction [PPM1D protein results in decreased phosphorylation of MAPK14 protein]18482988
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PPM1D mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of PPM1D mRNA21873647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPM1D mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPM1D protein22409540
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PPM1D mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPM1D mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PPM1D mRNA"20382639|2623829
D004958EstradiolEstradiol results in increased expression of PPM1D mRNA16514628
C044887beta-methylcholinebeta-methylcholine affects the expression of PPM1D mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1D mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PPM1D mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PPM1D mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PPM1D mRNA12414654
C018475butyraldehydebutyraldehyde results in increased expression of PPM1D mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PPM1D mRNA25596134
C037123cadmium sulfatecadmium sulfate results in decreased expression of PPM1D mRNA21783983
C004656chloroacetaldehydechloroacetaldehyde affects the expression of PPM1D mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PPM1D mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPM1D gene20938992
D004002Clodronic AcidClodronic Acid results in decreased expression of PPM1D mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of PPM1D mRNA19376846
D003078ColchicineColchicine results in decreased expression of PPM1D mRNA24211769
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PPM1D mRNA23640034
C014347decitabinedecitabine results in increased expression of PPM1D mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of PPM1D mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1D mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PPM1D mRNA28628672
D003976DiazinonDiazinon affects the expression of PPM1D mRNA22546817
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of PPM1D mRNA"22409540
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of PPM1D protein"22409540
D002945CisplatinCisplatin results in increased expression of PPM1D mRNA21532991|2330084
D002945CisplatinCisplatin results in increased expression of PPM1D mRNA24280081|2527062
D004147DioxinsDioxins results in decreased expression of PPM1D mRNA22100608
D004642EmodinEmodin results in increased expression of PPM1D mRNA16045814
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PPM1D mRNA23649840
D005047EtoposideEtoposide results in increased expression of PPM1D protein25078064
D011345FenofibrateFenofibrate results in decreased expression of PPM1D mRNA25596134
D005472FluorouracilFluorouracil results in increased expression of PPM1D mRNA17982676
D005472FluorouracilFluorouracil results in increased expression of PPM1D protein14665630
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of PPM1D mRNA]15016801
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of PPM1D mRNA]17982676
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPM1D gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PPM1D mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of PPM1D mRNA23649840
C070081fulvestrantfulvestrant results in decreased expression of PPM1D mRNA16514628
C039281furanfuran results in increased expression of PPM1D mRNA22079235
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PPM1D mRNA12414654
C031927hydroquinonehydroquinone results in increased expression of PPM1D mRNA23416264
D006918HydroxyureaHydroxyurea results in increased expression of PPM1D mRNA24211769
D007069IfosfamideIfosfamide results in decreased expression of PPM1D mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1D mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PPM1D mRNA28628672
C051890irinotecanirinotecan analog results in increased expression of PPM1D mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPM1D mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PPM1D mRNA28628672
C544151jinfukangjinfukang results in decreased expression of PPM1D mRNA27392435
D008345Manganese[Manganese co-treated with NGF protein] results in decreased expression of PPM1D protein25791630
D008345ManganeseManganese results in decreased expression of PPM1D protein25791630
D008345ManganesePPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased cleavage of PARP1 protein]25791630
D008345ManganesePPM1D mutant form promotes the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]25791630
D008345ManganesePPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased cleavage of PARP1 protein]25791630
D008345ManganesePPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]25791630
D008345ManganesePPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of MDM2 protein]25791630
D008345ManganesePPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]25791630
D008345ManganesePPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased phosphorylation of TP53 protein]25791630
C042720mercuric bromidemercuric bromide results in increased expression of PPM1D mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of PPM1D mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPM1D gene20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PPM1D mRNA22100608
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPM1D mRNA22100608|2364984
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PPM1D protein25078064
D009569Nitric OxideNitric Oxide results in increased expression of PPM1D mRNA15126337
C025589ochratoxin Aochratoxin A results in increased expression of PPM1D mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PPM1D mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of PPM1D mRNA25596134
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PPM1D mRNA18593933
C046012pentanalpentanal results in increased expression of PPM1D mRNA26079696
D019800PhenolPhenol results in increased expression of PPM1D mRNA17547211
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPM1D mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PPM1D mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in increased expression of PPM1D mRNA21061450
D010936Plant ExtractsPlant Extracts results in increased expression of PPM1D mRNA23557933
D011794QuercetinQuercetin results in increased expression of PPM1D mRNA21632981
D011794QuercetinQuercetin results in increased expression of PPM1D protein25078064
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of PPM1D mRNA16514628
C089730rosiglitazonerosiglitazone results in increased expression of PPM1D mRNA25596134
D018038Sodium SeleniteSodium Selenite results in increased expression of PPM1D mRNA18175754
D012989Soil PollutantsSoil Pollutants results in increased expression of PPM1D mRNA22409540
D012989Soil PollutantsSoil Pollutants results in increased expression of PPM1D protein22409540
D012989Soil Pollutantswortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein]22409540
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PPM1D mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PPM1D mRNA25729387
D014212TretinoinTretinoin results in increased expression of PPM1D mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PPM1D gene27618143
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PPM1D mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of PPM1D mRNA23179753|2915479
D000225AdenineAdenine results in decreased expression of PPM1D mRNA24211769
D024483Vitamin K 3Vitamin K 3 results in increased expression of PPM1D mRNA12414654
C009687wortmanninwortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein]22409540
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PPM1D mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004722protein serine/threonine phosphatase activity-IDA20801214  
GO:0005515protein binding-IPI17936559  20118229  22065775  
GO:0046872metal ion binding-IEA-  
GO:0051019mitogen-activated protein kinase binding-IPI21283629  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IEA-  
GO:0006306DNA methylation-ISS-  
GO:0006342chromatin silencing-ISS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006468protein phosphorylation-IEA-  
GO:0006470protein dephosphorylation-TAS9177166  
GO:0008285negative regulation of cell proliferation-TAS9177166  
GO:0009267cellular response to starvation-IEA-  
GO:0009314response to radiation-TAS9177166  
GO:0009617response to bacterium-IEA-  
GO:0035970peptidyl-threonine dephosphorylation-IDA20801214  
GO:0045814negative regulation of gene expression, epigenetic-IMP23242139  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA28343630  
GO:0005654nucleoplasm-TAS-  
GO:0005829cytosol-IDA28343630  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28483762Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. (2017 Aug 10)Zink FBlood