Gene: MASTL

84930
GREATWALL|GW|GWL|MAST-L|THC2
microtubule associated serine/threonine kinase like
protein-coding
10p12.1
Ensembl:ENSG00000120539 MIM:608221 Vega:OTTHUMG00000017855 UniprotKB:Q96GX5
NG_016987.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.129e-1 (AD)  7.549e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7091723chr10:27177236 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARMCX50.866
DHX360.861
HACL10.86
ODF2L0.851
C4orf330.85
BBS70.847
TSNAX0.846
SLC25A360.846
UCHL50.845
GLMN0.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.45
ACOX2-0.447
FOXJ1-0.426
WDR38-0.413
SALL3-0.41
ADAMTSL5-0.406
FAM151A-0.406
PLA2G5-0.397
NWD1-0.395
KCNJ16-0.389

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MASTL mRNA"28903501
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MASTL mRNA"19167446
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of MASTL mRNA25088246
D000082AcetaminophenAcetaminophen results in increased expression of MASTL mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of MASTL mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MASTL protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MASTL gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MASTL mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MASTL mRNA23630614
D001151ArsenicArsenic affects the methylation of MASTL gene25304211
D001151ArsenicArsenic results in increased methylation of MASTL promoter21291286
D001379AzathioprineAzathioprine results in decreased expression of MASTL mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MASTL mRNA20713471
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MASTL mRNA"20382639
D004958EstradiolEstradiol results in increased expression of MASTL mRNA16474171|1916744
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of MASTL mRNA]25210133
D004958EstradiolEstradiol results in increased expression of MASTL mRNA25210133
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MASTL mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of MASTL mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MASTL mRNA16474171
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MASTL mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of MASTL mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of MASTL mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MASTL mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MASTL mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of MASTL mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MASTL mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of MASTL mRNA27989131
D000069439DasatinibDasatinib results in decreased expression of MASTL mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MASTL mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MASTL mRNA28628672
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of MASTL mRNA28962523
D002945CisplatinCisplatin results in increased expression of MASTL mRNA27594783
D004008DiclofenacDiclofenac results in decreased expression of MASTL mRNA26934552
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MASTL protein23301498
D005485FlutamideFlutamide results in increased expression of MASTL mRNA24793618
C039281furanfuran results in increased expression of MASTL mRNA25539665
D019833GenisteinGenistein results in increased expression of MASTL mRNA16474171
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MASTL mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MASTL mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of MASTL mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MASTL mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MASTL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of MASTL mRNA28628672
C008261lead acetatelead acetate results in increased expression of MASTL mRNA22609695
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MASTL mRNA"24972896
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of MASTL mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of MASTL mRNA19564919
D008748MethylcholanthreneMethylcholanthrene results in increased expression of MASTL mRNA20713471
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of MASTL protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MASTL mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MASTL mRNA"25554681
D010416PentachlorophenolPentachlorophenol results in increased expression of MASTL mRNA24642059
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of MASTL mRNA16474171
D017035PravastatinPravastatin affects the expression of MASTL mRNA27225895
D017035PravastatinPravastatin results in decreased expression of MASTL mRNA27225895
D011794QuercetinQuercetin results in increased expression of MASTL mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of MASTL mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MASTL mRNA19167446
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of MASTL mRNA19564919
C534628SCH 23390SCH 23390 affects the expression of MASTL mRNA19564919
C075117squalestatin 1squalestatin 1 results in decreased expression of MASTL mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of MASTL mRNA27225895
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MASTL mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MASTL mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of MASTL mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of MASTL mRNA23411599
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MASTL mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MASTL mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MASTL mRNA19140230
D014635Valproic AcidValproic Acid results in decreased expression of MASTL mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MASTL gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA20538976  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IDA20818157  
GO:0051721protein phosphatase 2A binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IMP20538976  20818157  
GO:0000278mitotic cell cycle-IMP20538976  
GO:0006974cellular response to DNA damage stimulus-ISS-  
GO:0007147female meiosis II-IEA-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0032515negative regulation of phosphoprotein phosphatase activity-IMP20538976  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0051301cell division-IEA-  
GO:0051726regulation of cell cycle-IMP20818157  
GO:1904668positive regulation of ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA20538976  20818157  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0005813centrosome-IDA20538976  
GO:0032154cleavage furrow-IDA20538976  20818157  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1640170Cell CycleIEA
R-HSA-2465910MASTL Facilitates Mitotic ProgressionTAS
R-HSA-2465910MASTL Facilitates Mitotic ProgressionIEA
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68875Mitotic ProphaseIEA
R-HSA-68886M PhaseTAS
R-HSA-68886M PhaseIEA
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69278Cell Cycle, MitoticIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal