Gene: PPFIBP2

8495
Cclp1
PPFIA binding protein 2
protein-coding
11p15.4
Ensembl:ENSG00000166387 MIM:603142 Vega:OTTHUMG00000165617 UniprotKB:Q8ND30
NC_000011.10
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.340e-1 (AD)  6.169e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4472926chr11:7592118 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6578882chr11:7578160 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20244273chr11:7597349PPFIBP28.550e-10Maternal smoking in pregnancy27040690
cg20244273chr11:7597349PPFIBP26.270e-10Maternal smoking in pregnancy27040690
cg20244273chr11:7597349PPFIBP21.330e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDE10.842
LDLRAP10.84
FRMD4B0.824
PLEKHG30.819
C10orf900.812
SOX100.811
PIEZO20.807
PLD10.805
LLGL20.801
CLMN0.8

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH8-0.432
GLP2R-0.414
CNGB1-0.412
CUX2-0.411
KCNG3-0.407
GALNTL6-0.393
FFAR4-0.389
CNTN5-0.386
CTXN3-0.384
ADCYAP1-0.384

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PPFIBP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PPFIBP2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPFIBP2 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PPFIBP2 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPFIBP2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPFIBP2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PPFIBP2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of PPFIBP2 mRNA21757418
D001151ArsenicArsenic affects the methylation of PPFIBP2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PPFIBP2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPFIBP2 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of PPFIBP2 mRNA23019147
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PPFIBP2 mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of PPFIBP2 mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of PPFIBP2 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of PPFIBP2 mRNA26191083
C037123cadmium sulfatecadmium sulfate results in increased expression of PPFIBP2 mRNA16221973
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PPFIBP2 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of PPFIBP2 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of PPFIBP2 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of PPFIBP2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of PPFIBP2 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PPFIBP2 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PPFIBP2 mRNA28962523
D002945CisplatinCisplatin results in decreased expression of PPFIBP2 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of PPFIBP2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PPFIBP2 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PPFIBP2 mRNA16954407
C082360fipronilfipronil results in increased expression of PPFIBP2 mRNA23962444
D005485FlutamideFlutamide results in increased expression of PPFIBP2 mRNA24793618
D005897GlafenineGlafenine results in decreased expression of PPFIBP2 mRNA24136188
C492448ICG 001ICG 001 results in increased expression of PPFIBP2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PPFIBP2 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of PPFIBP2 mRNA20003209
D007854LeadLead results in decreased expression of PPFIBP2 mRNA19921347
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PPFIBP2 mRNA21641980
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PPFIBP2 mRNA22776087
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PPFIBP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PPFIBP2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PPFIBP2 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of PPFIBP2 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PPFIBP2 mRNA25729387
D010126OzoneOzone results in decreased expression of PPFIBP2 mRNA12763052
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPFIBP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PPFIBP2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of PPFIBP2 mRNA17426115
D011374ProgesteronePPFIBP2 gene SNP affects the susceptibility to Progesterone25622337
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PPFIBP2 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPFIBP2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PPFIBP2 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PPFIBP2 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of PPFIBP2 mRNA22714537
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PPFIBP2 mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PPFIBP2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PPFIBP2 mRNA21592394
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PPFIBP2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPFIBP2 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPFIBP2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PPFIBP2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PPFIBP2 mRNA22378314
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PPFIBP2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of PPFIBP2 mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of PPFIBP2 mRNA16604517
C012589trichostatin Atrichostatin A results in decreased expression of PPFIBP2 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of PPFIBP2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PPFIBP2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PPFIBP2 mRNA23527032|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PPFIBP2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI19447967  26871637  27107014  
GO:0042802identical protein binding-IDA21462929  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0005622intracellular-TAS9624153  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-388844Receptor-type tyrosine-protein phosphatasesTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal