Gene: FBXL20

84961
Fbl2|Fbl20
F-box and leucine rich repeat protein 20
protein-coding
17q12
Ensembl:ENSG00000108306 MIM:609086 Vega:OTTHUMG00000179002 UniprotKB:Q96IG2
NC_000017.11
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.113e-1 (AD)  2.953e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13341996chr17:39380609 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4511574chr17:39376663 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs8069451chr17:39348680 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs7220650chr17:39330915 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs585961chr17:39287783 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TP53BP10.881
ZNF6230.871
RNF1110.862
RANBP20.85
TNPO30.847
PRR14L0.846
TMCC10.845
GNE0.842
FITM20.842
POLR3D0.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APOM-0.436
ASB4-0.414
COPZ2-0.408
C19orf18-0.404
COX4I2-0.401
HES1-0.391
ALDH1L1-AS2-0.386
OR4F5-0.38
PHYHD1-0.378
CSAG1-0.364

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXL20 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXL20 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of FBXL20 mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of FBXL20 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXL20 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXL20 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of FBXL20 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FBXL20 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FBXL20 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FBXL20 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FBXL20 mRNA16483693
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FBXL20 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FBXL20 mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of FBXL20 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FBXL20 mRNA15034205
C006780bisphenol Abisphenol A results in increased expression of FBXL20 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of FBXL20 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FBXL20 mRNA26079696
D002104CadmiumCadmium results in decreased expression of FBXL20 mRNA23369406
D002737ChloropreneChloroprene results in increased expression of FBXL20 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in increased expression of FBXL20 mRNA19320972
C089595cylindrospermopsincylindrospermopsin results in increased expression of FBXL20 mRNA24921660
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of FBXL20 mRNA23640034
C014347decitabinedecitabine affects the expression of FBXL20 mRNA23300844
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of FBXL20 mRNA"25908611
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FBXL20 mRNA21266533
D002945CisplatinCisplatin affects the expression of FBXL20 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of FBXL20 mRNA27594783
D000431EthanolEthanol results in decreased expression of FBXL20 mRNA19167417
D005485FlutamideFlutamide results in decreased expression of FBXL20 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FBXL20 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of FBXL20 mRNA20003209
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of FBXL20 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of FBXL20 mRNA24796395
C045463leflunomideleflunomide results in increased expression of FBXL20 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FBXL20 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FBXL20 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FBXL20 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FBXL20 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FBXL20 mRNA"25554681
D009281NaphthalenesNaphthalenes results in decreased expression of FBXL20 protein17337753
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXL20 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FBXL20 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of FBXL20 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of FBXL20 mRNA21278054
C010313pseudocumenepseudocumene results in decreased expression of FBXL20 protein17337753
C031389resorcinolresorcinol results in decreased expression of FBXL20 mRNA22623647
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of FBXL20 mRNA21427059
D012834SilverSilver results in increased expression of FBXL20 mRNA27131904
D053260SootSoot results in decreased expression of FBXL20 mRNA22461453
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of FBXL20 mRNA19074003
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of FBXL20 mRNA25172293
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FBXL20 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FBXL20 mRNA15034205|1946511
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FBXL20 mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of FBXL20 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FBXL20 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FBXL20 mRNA28973697
D014520UrethaneUrethane results in increased expression of FBXL20 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FBXL20 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FBXL20 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FBXL20 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of FBXL20 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FBXL20 gene25560391
C025643vinclozolinvinclozolin affects the expression of FBXL20 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of FBXL20 mRNA23869203
D014750VincristineVincristine results in decreased expression of FBXL20 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of FBXL20 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activityCONTRIBUTES_TOIBA21873635  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0005515protein binding-IPI27705803  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0001662behavioral fear response-IEA-  
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0019005SCF ubiquitin ligase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal