Gene: AJUBA

84962
JUB
ajuba LIM protein
protein-coding
14q11.2
Ensembl:ENSG00000129474 MIM:609066 Vega:OTTHUMG00000028711 UniprotKB:Q96IF1
NC_000014.9
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.202e-1 (AD)  4.545e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LATS20.756
CNN20.753
SYDE10.749
NES0.718
TES0.709
TCF70.708
EPS80.701
EBF10.699
EVC20.697
FOXC10.69

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASIC2-0.559
CKMT1A-0.545
VSTM5-0.536
CDH8-0.535
KCNB2-0.535
BCL11A-0.533
SLC7A4-0.533
GPR150-0.532
GFRA2-0.531
SVOP-0.53

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of AJUBA mRNA"22101062
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AJUBA mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AJUBA mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AJUBA mRNA"21346803
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of AJUBA mRNA"24172598
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of AJUBA mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AJUBA mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C0757734-phenylbutyric acid4-phenylbutyric acid results in decreased expression of AJUBA mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of AJUBA mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of AJUBA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AJUBA protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AJUBA mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AJUBA mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AJUBA mRNA14625279
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of AJUBA mRNA]14625279
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of AJUBA mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of AJUBA mRNA]20847119
D019256Cadmium ChlorideCadmium Chloride results in increased expression of AJUBA mRNA21297351
D002220CarbamazepineCarbamazepine affects the expression of AJUBA mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of AJUBA mRNA27339419
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AJUBA mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of AJUBA mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of AJUBA mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of AJUBA mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AJUBA mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of AJUBA mRNA19167446
C030973cupric oxidecupric oxide results in decreased expression of AJUBA mRNA22077320
D003471CuprizoneCuprizone results in increased expression of AJUBA mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of AJUBA mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AJUBA mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AJUBA mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AJUBA mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of AJUBA mRNA18042831|1903023
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AJUBA mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AJUBA mRNA24535843
D004237DiuronDiuron metabolite results in decreased expression of AJUBA mRNA24172598
D004237DiuronDiuron results in increased expression of AJUBA mRNA21551480
C118739entinostatentinostat results in decreased expression of AJUBA mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AJUBA mRNA22079256
C540355fenamidonefenamidone results in increased expression of AJUBA mRNA27029645
D005485FlutamideFlutamide results in decreased expression of AJUBA mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AJUBA mRNA20938992
C039281furanfuran results in increased expression of AJUBA mRNA25539665
D017313FenretinideFenretinide results in increased expression of AJUBA mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of AJUBA mRNA20044591
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AJUBA mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AJUBA mRNA27392435
D007854LeadLead affects the expression of AJUBA mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of AJUBA mRNA12057914
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AJUBA mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AJUBA mRNA28001369
D015735MifepristoneMifepristone results in decreased expression of AJUBA mRNA25972201
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of AJUBA mRNA16809437
C028577monobutyl phthalatemonobutyl phthalate affects the expression of AJUBA mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of AJUBA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AJUBA mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of AJUBA mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of AJUBA mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of AJUBA mRNA18042831
D010622PhencyclidinePhencyclidine results in increased expression of AJUBA mRNA12105081
D010634PhenobarbitalPhenobarbital affects the expression of AJUBA mRNA19159669
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AJUBA mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of AJUBA mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of AJUBA mRNA19270015|1948288
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA20847119
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AJUBA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AJUBA mRNA22079256
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of AJUBA mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of AJUBA mRNA]14625279
C513428pyrachlostrobinpyrachlostrobin results in increased expression of AJUBA mRNA27029645
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA20847119
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of AJUBA mRNA25895662
D012834SilverSilver results in increased expression of AJUBA mRNA28959546
C016104sodium bichromatesodium bichromate results in increased expression of AJUBA mRNA25993096
D013629TamoxifenTamoxifen affects the expression of AJUBA mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AJUBA mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AJUBA mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AJUBA mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of AJUBA mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of AJUBA mRNA25729387
D019772TopotecanTopotecan results in increased expression of AJUBA mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of AJUBA mRNA26272509
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AJUBA mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of AJUBA mRNA]20847119
D014520UrethaneUrethane results in decreased expression of AJUBA mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of AJUBA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of AJUBA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of AJUBA mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of AJUBA mRNA23179753|2718838
C025643vinclozolinvinclozolin affects the expression of AJUBA mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of AJUBA mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA18805794  
GO:0005515protein binding-IPI15778465  16413547  18331720  18805794  20303269  20616046  
22286099  25314079  
GO:0045294alpha-catenin binding-IDA12417594  
GO:0046872metal ion binding-IEA-  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001666response to hypoxia-IBA21873635  
GO:0001666response to hypoxia-IDA22286099  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0007010cytoskeleton organization-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IEA-  
GO:0030032lamellipodium assembly-IEA-  
GO:0030334regulation of cell migration-IEA-  
GO:0031328positive regulation of cellular biosynthetic process-IEA-  
GO:0031334positive regulation of protein complex assembly-IDA15870274  
GO:0033673negative regulation of kinase activity-IEA-  
GO:0034613cellular protein localization-IEA-  
GO:0035195gene silencing by miRNA-IMP20616046  
GO:0035313wound healing, spreading of epidermal cells-IEA-  
GO:0035329hippo signaling-IBA21873635  
GO:0035331negative regulation of hippo signaling-IBA21873635  
GO:0035331negative regulation of hippo signaling-IDA20303269  
GO:0043087regulation of GTPase activity-IEA-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEA-  
GO:0043406positive regulation of MAP kinase activity-IEA-  
GO:0046474glycerophospholipid biosynthetic process-IEA-  
GO:0048041focal adhesion assembly-IEA-  
GO:1900037regulation of cellular response to hypoxia-IDA22286099  
GO:2000637positive regulation of gene silencing by miRNA-IBA21873635  
GO:2000637positive regulation of gene silencing by miRNA-IMP20616046  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-IBA21873635  
GO:0000932P-body-IDA20616046  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18805794  
GO:0005667transcription factor complex-IBA21873635  
GO:0005794Golgi apparatus-IDA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-IDA12417594  
GO:0005912adherens junction-IBA21873635  
GO:0005925focal adhesion-IEA-  
GO:0030027lamellipodium-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenTAS
R-HSA-1234174Regulation of Hypoxia-inducible Factor (HIF) by oxygenIEA
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaTAS
R-HSA-1234176Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1640170Cell CycleTAS
R-HSA-2262749Cellular response to hypoxiaTAS
R-HSA-2262749Cellular response to hypoxiaIEA
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2262752Cellular responses to stressIEA
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25631445Comprehensive genomic characterization of head and neck squamous cell carcinomas. (2015 Jan 29)-Nature
25839328Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma. (2015 Apr 2)Zhang LAm J Hum Genet
26873401Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. (2016 May)Sawada GGastroenterology