Gene: TOX2

84969
C20orf100|GCX-1|GCX1|dJ1108D11.2|dJ495O3.1
TOX high mobility group box family member 2
protein-coding
20q13.12
Ensembl:ENSG00000124191 MIM:611163 Vega:OTTHUMG00000032517 UniprotKB:Q96NM4
NC_000020.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.243e-2 (AD)  2.876e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INA0.908
IGLON50.905
ATP1A30.904
NEFL0.904
SULT4A10.903
NEFM0.901
NEFH0.899
PELI30.899
SV2A0.896
RAB3A0.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.531
REST-0.52
WWTR1-0.491
YES1-0.488
SGMS2-0.476
LRAT-0.473
OR4F5-0.47
ARHGEF5-0.469
BAZ1A-0.466
CNN2-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX2 mRNA"27188386
D000447AldehydesAldehydes results in increased expression of TOX2 mRNA25014914
D001151ArsenicArsenic affects the methylation of TOX2 gene25304211
C487081belinostatbelinostat results in decreased expression of TOX2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TOX2 mRNA"19150397|2038263
C006780bisphenol Abisphenol A results in increased expression of TOX2 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of TOX2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of TOX2 mRNA26079696
C584509C646 compoundC646 compound affects the expression of TOX2 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of TOX2 mRNA25979313
D002737ChloropreneChloroprene results in increased expression of TOX2 mRNA23125180
D016572CyclosporineCyclosporine results in increased expression of TOX2 mRNA27989131
C014347decitabinedecitabine affects the expression of TOX2 mRNA23300844
D002945CisplatinCisplatin affects the expression of TOX2 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of TOX2 mRNA19561079
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of TOX2 mRNA26924002
C118739entinostatentinostat results in increased expression of TOX2 mRNA27188386
C492448ICG 001ICG 001 results in increased expression of TOX2 mRNA26191083
C544151jinfukangjinfukang results in increased expression of TOX2 mRNA27392435
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TOX2 mRNA26378955
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of TOX2 mRNA20843944
C517284monomethyl phthalatemonomethyl phthalate affects the expression of TOX2 mRNA26924002
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of TOX2 mRNA24888373
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of TOX2 mRNA26272509
C046012pentanalpentanal results in increased expression of TOX2 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TOX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TOX2 mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of TOX2 mRNA23557933
D010938Plant OilsPlant Oils results in decreased expression of TOX2 mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of TOX2 mRNA24888373
D011374ProgesteroneProgesterone results in increased expression of TOX2 mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of TOX2 mRNA26079696
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TOX2 mRNA"16251409
D012834SilverSilver results in increased expression of TOX2 mRNA27131904
D018038Sodium SeleniteSodium Selenite results in increased expression of TOX2 mRNA24383545
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of TOX2 mRNA26378955
D013849ThimerosalThimerosal results in decreased expression of TOX2 mRNA27188386
C012589trichostatin Atrichostatin A results in increased expression of TOX2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TOX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TOX2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TOX2 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of TOX2 mRNA22714537
D019287Zinc SulfateZinc Sulfate results in increased expression of TOX2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA25352127  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA25352127  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA25352127  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29796116Genome-wide analysis of DNA methylation in bronchial washings. (2018)Um SWClin Epigenetics
22496870Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers. (2012)Tessema MPLoS One