Gene: FAM83A

84985
BJ-TSA-9
family with sequence similarity 83 member A
protein-coding
8q24.13
Ensembl:ENSG00000147689 Vega:OTTHUMG00000165083 UniprotKB:Q86UY5
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.804e-1 (AD)  7.387e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTCFL0.849
RHAG0.831
IGF2BP10.821
MAGEA10.802
PRAME0.801
HOXB90.796
HBG10.794
PAGE50.784
MAGEA30.762
MAGEA60.76

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERBB4-0.285
HAPLN1-0.283
KIT-0.277
C1orf53-0.269
CRH-0.258
VWC2-0.257
ABCD2-0.249
ACSL6-0.249
DLX1-0.246
PAH-0.242

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of FAM83A gene28458013
C015001arsenitearsenite results in decreased expression of FAM83A mRNA19716837
C015001arsenitearsenite results in increased methylation of FAM83A promoter19716837
C006780bisphenol Abisphenol A results in decreased expression of FAM83A mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FAM83A mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of FAM83A mRNA26472689
C100187chloropicrinchloropicrin results in decreased expression of FAM83A mRNA28476498
C014347decitabine[decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of FAM83A promoter]18448484
C014347decitabinedecitabine inhibits the reaction [sodium arsenite affects the methylation of FAM83A promoter]18448484
D003976DiazinonDiazinon results in increased methylation of FAM83A gene22964155
C406082monomethylarsonous acid[monomethylarsonous acid affects the acetylation of HIST3H3 protein] which affects the methylation of FAM83A promoter18448484
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of FAM83A mRNA18448484|1971683
C406082monomethylarsonous acidmonomethylarsonous acid results in increased methylation of FAM83A promoter19716837
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FAM83A mRNA25895662
D012906SmokeSmoke results in decreased expression of FAM83A mRNA21095227
C017947sodium arsenite[decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of FAM83A promoter]18448484
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite affects the methylation of FAM83A promoter]18448484
C017947sodium arsenite[sodium arsenite affects the acetylation of HIST3H3 protein] which affects the methylation of FAM83A promoter18448484
C017947sodium arsenitesodium arsenite results in decreased expression of FAM83A mRNA18448484
C017947sodium arsenitesodium arsenite results in decreased methylation of FAM83A gene24570342
C017947sodium arsenitesodium arsenite results in increased expression of FAM83A mRNA24570342
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM83A mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FAM83A mRNA28065790
D014212TretinoinTretinoin results in increased expression of FAM83A mRNA23830798
C012589trichostatin A[decitabine co-treated with trichostatin A] inhibits the reaction [sodium arsenite affects the methylation of FAM83A promoter]18448484
D014635Valproic AcidValproic Acid results in increased methylation of FAM83A gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of FAM83A gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0019901protein kinase binding-IDA22886303  
GO:0019901protein kinase binding-IPI22886303  24736947  
GO:0036312phosphatidylinositol 3-kinase regulatory subunit binding-IDA22886303  
GO ID GO Term Qualifier Evidence PubMed
GO:0007173epidermal growth factor receptor signaling pathway-IDA22886303  
GO:0008283cell proliferation-IMP22886303  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26081616RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients. (2015 Nov)Li YTumour Biol