Gene: PPFIA2

8499
-
PTPRF interacting protein alpha 2
protein-coding
12q21.31
Ensembl:ENSG00000139220 MIM:603143 Vega:OTTHUMG00000170181 UniprotKB:O75334
NC_000012.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.885e-1 (AD)  5.415e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2400954chr12:81539202 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADAM220.969
NLK0.965
CHL10.961
GRIA20.961
ATL10.96
SCN2A0.96
WDR470.958
CNKSR20.957
GABRB30.956
ARHGEF90.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.52
HEY2-0.482
OR4F5-0.478
CNN2-0.477
RNF135-0.474
RAB13-0.466
TFPI2-0.461
RUNX3-0.458
EMP3-0.452
WWTR1-0.45

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of PPFIA2 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PPFIA2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PPFIA2 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPFIA2 mRNA22316170
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of PPFIA2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PPFIA2 mRNA25181051
D013759DronabinolDronabinol results in decreased expression of PPFIA2 mRNA16616335
D004041Dietary FatsDietary Fats results in increased expression of PPFIA2 mRNA25016146
C118739entinostatentinostat results in decreased expression of PPFIA2 mRNA27188386
C069837fullerene C60fullerene C60 results in decreased expression of PPFIA2 mRNA19167457
C039281furanfuran results in increased expression of PPFIA2 mRNA25539665
D007854LeadLead affects the expression of PPFIA2 mRNA28903495
C006253pirinixic acidpirinixic acid results in increased expression of PPFIA2 mRNA20813756
C017947sodium arsenitesodium arsenite affects the methylation of PPFIA2 gene28589171
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of PPFIA2 mRNA26496021
D014520UrethaneUrethane results in decreased expression of PPFIA2 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12923177  
GO ID GO Term Qualifier Evidence PubMed
GO:0007160cell-matrix adhesion-TAS9624153  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS9624153  
GO:0005829cytosol-TAS-  
GO:0009986cell surface-IEA-  
GO:0048786presynaptic active zone-TAS15217342  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-181429Serotonin Neurotransmitter Release CycleTAS
R-HSA-181430Norepinephrine Neurotransmitter Release CycleTAS
R-HSA-210500Glutamate Neurotransmitter Release CycleTAS
R-HSA-212676Dopamine Neurotransmitter Release CycleTAS
R-HSA-264642Acetylcholine Neurotransmitter Release CycleTAS
R-HSA-388844Receptor-type tyrosine-protein phosphatasesTAS
R-HSA-6794362Protein-protein interactions at synapsesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal