Gene: TMEM128

85013
-
transmembrane protein 128
protein-coding
4p16.3
Ensembl:ENSG00000132406 Vega:OTTHUMG00000125475 UniprotKB:Q5BJH2
NC_000004.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.285e-2 (AD)  5.510e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2916464chr4:4247893 (GRCh38.p7)T>A / T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2916468chr4:4247573 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2980103chr4:4244013 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LSM50.844
LYPLAL10.84
DCTN60.836
ZNF2260.828
ANAPC100.821
DAZAP20.821
NMD30.819
DUS4L0.819
TM2D10.814
ALG50.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.57
OR4F29-0.544
EPPIN-0.358
MMP23B-0.288
RAX2-0.288
SLFNL1-0.255
MTRNR2L9-0.252
SLC7A9-0.249
MTRNR2L6-0.243
CELSR1-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of TMEM128 protein26194647
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to TMEM128 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TMEM128 protein]26598702
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to TMEM128 protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TMEM128 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of TMEM128 mRNA25181051
D019327Copper SulfateCopper Sulfate results in decreased expression of TMEM128 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TMEM128 mRNA25562108
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of TMEM128 mRNA"25908611
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of TMEM128 mRNA22634610
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of TMEM128 mRNA19376150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TMEM128 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TMEM128 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TMEM128 mRNA"25554681|2562005
D010578PetroleumPetroleum results in increased expression of TMEM128 mRNA25208076
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TMEM128 mRNA19710929
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TMEM128 mRNA22714537
D011794QuercetinQuercetin results in increased expression of TMEM128 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of TMEM128 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TMEM128 mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of TMEM128 mRNA23409001
C066340tolcaponetolcapone results in decreased expression of TMEM128 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of TMEM128 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TMEM128 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TMEM128 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of TMEM128 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal