Gene: PKP4

8502
p0071
plakophilin 4
protein-coding
2q24.1
Ensembl:ENSG00000144283 MIM:604276 Vega:OTTHUMG00000153969 UniprotKB:Q99569
NC_000002.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.404e-1 (AD)  2.500e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17421757chr2:158602089 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM410.904
PTP4A20.901
GAB20.891
DYNC1LI20.887
MBP0.886
TRAK20.883
ANKRD400.88
MAP40.88
MCM70.87
FOXO40.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.488
OR4F5-0.402
NEUROD1-0.298
LTK-0.272
HS3ST3A1-0.265
CUX2-0.264
MSX2-0.26
OLFM4-0.253
NHS-0.25
ASGR2-0.248

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PKP4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of PKP4 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of PKP4 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKP4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP4 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of PKP4 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PKP4 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PKP4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PKP4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PKP4 gene27153756
D001280AtrazineAtrazine results in increased expression of PKP4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKP4 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PKP4 mRNA"19150397|2038263
C044887beta-methylcholinebeta-methylcholine affects the expression of PKP4 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PKP4 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of PKP4 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PKP4 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of PKP4 mRNA26079696
D002104CadmiumCadmium results in decreased expression of PKP4 mRNA23369406
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PKP4 mRNA17484886
C018021cobaltous chloridecobaltous chloride results in decreased expression of PKP4 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of PKP4 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of PKP4 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of PKP4 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of PKP4 mRNA21865292
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PKP4 mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of PKP4 mRNA19030233
D002117CalcitriolCalcitriol results in decreased expression of PKP4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PKP4 mRNA21592394
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of PKP4 mRNA27638505
D004237DiuronDiuron results in decreased expression of PKP4 mRNA21551480
C118739entinostatentinostat results in decreased expression of PKP4 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PKP4 mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKP4 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of PKP4 mRNA24136188|2479361
D005557FormaldehydeFormaldehyde results in decreased expression of PKP4 mRNA23649840
D005897GlafenineGlafenine results in decreased expression of PKP4 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of PKP4 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of PKP4 mRNA16984733
D007657Ketone BodiesKetone Bodies results in increased expression of PKP4 mRNA16807920
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PKP4 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP4 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PKP4 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PKP4 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PKP4 promoter"26251327
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PKP4 protein24625837
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PKP4 mRNA19074003
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PKP4 mRNA25729387
D010634PhenobarbitalPhenobarbital results in decreased expression of PKP4 mRNA23091169
D010656PhenylephrinePhenylephrine results in decreased expression of PKP4 mRNA18158353
D011794QuercetinQuercetin results in decreased expression of PKP4 mRNA21632981
D020123SirolimusSirolimus results in increased expression of PKP4 mRNA21865292
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PKP4 mRNA"26680231
D016559TacrolimusTacrolimus results in decreased expression of PKP4 mRNA21865292
C061133tamibarotenetamibarotene results in decreased expression of PKP4 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PKP4 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PKP4 mRNA21592394
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PKP4 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PKP4 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKP4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PKP4 mRNA21215274
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PKP4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PKP4 mRNA15498508
C057693troglitazonetroglitazone results in decreased expression of PKP4 mRNA28973697
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PKP4 gene25560391
C088658zoledronic acidzoledronic acid results in decreased expression of PKP4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10092585  12047349  16203728  17115030  19706687  22965878  
24550280  25416956  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007043cell-cell junction assembly-ISS-  
GO:0007267cell-cell signaling-NAS8937994  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0030155regulation of cell adhesion-NAS8937994  
GO:0031424keratinization-TAS-  
GO:0032467positive regulation of cytokinesis-IMP17115030  
GO:0043547positive regulation of GTPase activity-IDA17115030  
GO:0070268cornification-TAS-  
GO:0098609cell-cell adhesion-IBA21873635  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IDA17115030  
GO:0001533cornified envelope-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA22965878  
GO:0005856cytoskeleton-IDA8937994  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA8937994  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-IDA8937994  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009898cytoplasmic side of plasma membrane-IDA17115030  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IDA-  
GO:0030057desmosome-IDA8937994  
GO:0030496midbody-IDA17115030  
GO:0030496midbodycolocalizes_withIDA22965878  
GO:0044291cell-cell contact zonecolocalizes_withIDA22965878  
GO:0048471perinuclear region of cytoplasm-IDA8937994  
GO:0051233spindle midzone-IDA17115030  
GO:0072686mitotic spindle-IDA17115030  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal