Gene: REPS1

85021
NBIA7|RALBP1
RALBP1 associated Eps domain containing 1
protein-coding
6q24.1
Ensembl:ENSG00000135597 MIM:614825 Vega:OTTHUMG00000015685 UniprotKB:Q96D71
NG_034016.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  9.140e-1 (ND)   (Frontal_Cortex)
2.486e-1 (AD)  5.036e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2272432chr6:138917462 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11249390chr6:139306200REPS1Gene body3.317e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ICA1L0.894
KIAA03190.877
CCPG10.873
POLR3F0.869
TRIM90.866
GPHN0.861
MOK0.86
TTC80.857
GLE10.855
MRPS250.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.53
OR4F29-0.481
MTRNR2L9-0.384
TFPI2-0.38
SGMS2-0.376
SH2D1A-0.36
MTRNR2L6-0.359
KLRB1-0.356
GZMA-0.356
C16orf54-0.356

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of REPS1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of REPS1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of REPS1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of REPS1 mRNA22100608
C006780bisphenol Abisphenol A results in increased expression of REPS1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of REPS1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of REPS1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of REPS1 mRNA27339419
D016572CyclosporineCyclosporine results in increased expression of REPS1 mRNA25562108|2798913
D003703DemecolcineDemecolcine results in increased expression of REPS1 mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of REPS1 mRNA]27941970
D004041Dietary FatsDietary Fats results in increased expression of REPS1 mRNA25016146
D005472FluorouracilREPS1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D005839GentamicinsGentamicins results in increased expression of REPS1 mRNA22061828
D007052IbuprofenIbuprofen results in increased expression of REPS1 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REPS1 mRNA25613284
C051890irinotecanirinotecan analog results in decreased expression of REPS1 mRNA18927307
C051890irinotecanREPS1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog]18927307
D008713MethimazoleMethimazole results in decreased expression of REPS1 mRNA22504374
D008727MethotrexateMethotrexate results in increased expression of REPS1 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of REPS1 mRNA26272509|2800136
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of REPS1 mRNA24128854
C016030pantogabpantogab results in increased expression of REPS1 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of REPS1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of REPS1 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of REPS1 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of REPS1 mRNA22504374
D011748PyrogallolPyrogallol results in increased expression of REPS1 mRNA20362636
C059514resveratrolresveratrol results in decreased expression of REPS1 protein18089832
D012402RotenoneRotenone results in decreased expression of REPS1 mRNA19013527
D018038Sodium SeleniteSodium Selenite results in increased expression of REPS1 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of REPS1 mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REPS1 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of REPS1 protein24648495
D013849ThimerosalThimerosal results in increased expression of REPS1 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of REPS1 mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of REPS1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of REPS1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased methylation of REPS1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of REPS1 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of REPS1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of REPS1 mRNA23034163
D014750VincristineVincristine results in increased expression of REPS1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI20946875  23211419  
GO:0017124SH3 domain binding-IPI20946875  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0061024membrane organization-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA20946875  
GO:0005905clathrin-coated pit-IDA20946875  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal