Gene: PEX3

8504
PBD10A|PBD10B|TRG18
peroxisomal biogenesis factor 3
protein-coding
6q24.2
Ensembl:ENSG00000034693 MIM:603164 Vega:OTTHUMG00000015730 UniprotKB:P56589
NG_008459.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.914e-1 (AD)  6.917e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC400.917
CUL50.902
NAE10.9
ATAD10.899
HLTF0.899
TRAPPC130.897
PPP1R20.896
TXNDC90.893
TSNAX0.891
PWP10.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.543
OR4F29-0.484
MTRNR2L9-0.424
MTRNR2L6-0.422
MTRNR2L10-0.394
CSAG1-0.377
MTRNR2L2-0.367
MTRNR2L8-0.363
MMP23B-0.332
TNFRSF10D-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PEX3 mRNA"19114083
D000082AcetaminophenAcetaminophen results in decreased expression of PEX3 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of PEX3 mRNA26690555
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PEX3 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PEX3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of PEX3 mRNA15761015
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of PEX3 mRNA15894607
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PEX3 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PEX3 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of PEX3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PEX3 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of PEX3 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PEX3 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of PEX3 mRNA25979313
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of PEX3 mRNA27174168
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of PEX3 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of PEX3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PEX3 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PEX3 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in decreased expression of PEX3 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of PEX3 mRNA16002434
D004237DiuronDiuron results in increased expression of PEX3 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PEX3 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PEX3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PEX3 mRNA17942748
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PEX3 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of PEX3 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PEX3 mRNA23458150
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PEX3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PEX3 mRNA"25620056
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PEX3 mRNA19429403|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PEX3 mRNA19429403
C031181phenanthrenephenanthrene results in increased expression of PEX3 mRNA19457238
C006253pirinixic acidpirinixic acid results in increased expression of PEX3 mRNA17426115|1830175
D010936Plant ExtractsPlant Extracts results in increased expression of PEX3 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PEX3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PEX3 mRNA22079256
C015586propiverinepropiverine affects the localization of PEX3 protein29273565
D011441PropylthiouracilPropylthiouracil results in increased expression of PEX3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PEX3 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of PEX3 mRNA20436886
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of PEX3 mRNA19244175
D012643SeleniumSelenium results in decreased expression of PEX3 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PEX3 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PEX3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PEX3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEX3 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PEX3 mRNA25613284
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of PEX3 mRNA15894607
D014635Valproic AcidValproic Acid results in decreased methylation of PEX3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PEX3 mRNA23179753|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PEX3 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PEX3 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of PEX3 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of PEX3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10704444  11883941  12096124  16189514  16280322  18174172  
19715730  21102411  25416956  27107012  
GO:0008289lipid binding-IDA19715730  
GO:0046983protein dimerization activity-IDA19715730  
GO ID GO Term Qualifier Evidence PubMed
GO:0007031peroxisome organization-IMP10958759  12924628  18174172  19479899  
GO:0016557peroxisome membrane biogenesis-IEA-  
GO:0045046protein import into peroxisome membrane-IMP15007061  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005777peroxisome-IDA9922452  
GO:0005777peroxisome-IMP12924628  
GO:0005778peroxisomal membrane-HDA21525035  
GO:0005778peroxisomal membrane-TAS-  
GO:0005779integral component of peroxisomal membrane-IDA9657383  10430017  
GO:0005783endoplasmic reticulum-IDA19479899  21768384  
GO:0005829cytosol-IEA-  
GO:0016020membrane-HDA19946888  
GO:0032991protein-containing complex-IDA18174172  
GO:0032994protein-lipid complex-IDA19715730  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27859136KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer. (2017 Feb 15)Nagy AInt J Cancer